Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the sulfolobus solfataricus DNA polymerase Dpo4

Chemical Research in Toxicology

Volumn 26, Issue 9, 2013, Pages 1348-1360

  Shanmugam, Ganesh ^a,c   Minko, Irina G ^b   Banerjee, Surajit ^a,d   Christov, Plamen P ^a   Kozekov, Ivan D ^a   Rizzo, Carmelo J ^a   Lloyd, R Stephen ^b   Egli, Martin ^a   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^d Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 5,6,7,8 TETRAHYDRO 8 HYDROXYPYRIMIDO(1,2 A)PURIN 10 (3H)ONE; DEOXYGUANOSINE; DNA POLYMERASE; DNA POLYMERASE DPO4; HYDROGEN; PARATHION; PURINE DERIVATIVE; UNCLASSIFIED DRUG; 3-(2-DEOXYPENTOFURANOSYL)-5,6,7,8-TETRAHYDRO-8-HYDROXY-6-TRIDECYLPYRIMIDO(1,2-A)PURINE-10(3H)ONE; DNA ADDUCT; DNA DIRECTED DNA POLYMERASE BETA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; BIOTRANSFORMATION; DNA CONFORMATION; DNA DETERMINATION; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; RING OPENING; SULFOLOBUS SOLFATARICUS; X RAY DIFFRACTION; CHEMICAL STRUCTURE; CHEMISTRY; DNA ADDUCT; ENZYMOLOGY; METABOLISM; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DEOXYGUANOSINE; DNA ADDUCTS; DNA POLYMERASE BETA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SULFOLOBUS SOLFATARICUS;

EID: 84884265199     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400200b     Document Type: Article

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