Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A

Biochemistry

Volumn 52, Issue 37, 2013, Pages 6368-6379

  Bastidas, Adam C ^a   Pierce, Levi C ^b   Walker, Ross C ^b,c   Johnson, David A ^d   Taylor, Susan S ^a,b  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; CATALYTIC SUBUNITS; GLOBAL EFFECTS; LIGAND BINDING; MD SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN KINASE A; TIME RESOLVED FLUORESCENCE ANISOTROPY;

ACYLATION; AMINO ACIDS; ANISOTROPY; ENZYMES; EXPERIMENTS; MOLECULAR DYNAMICS; PROTEINS;

LIGANDS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; MALEIMIDE; MUTANT PROTEIN; MYRISTIC ACID;

AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; LIGAND BINDING; MOLECULAR DYNAMICS; MYRISTYLATION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SIMULATION; SOLVATION;

ACYLATION; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME STABILITY; FLUORESCENCE POLARIZATION; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MYRISTIC ACID; PROTEIN CONFORMATION;

EID: 84884258284     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400575k     Document Type: Article

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