A membrane vesicle-based assay to enable prediction of human biliary excretion

Xenobiotica

Volumn 43, Issue 10, 2013, Pages 915-919

  Colombo, Federico ^a   Poirier, Hugo ^a   Rioux, Nathalie ^a   Montecillo, Maria Arias ^a   Duan, Jianmin ^a   Ribadeneira, Maria D ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Biliary excretion; Drug drug interaction; Human; Multi drug resistance protein 2

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; BENZBROMARONE; DIGOXIN; FLUINDOSTATIN; FUROSEMIDE; MULTIDRUG RESISTANCE PROTEIN 2; PACLITAXEL; PRAVASTATIN; RITONAVIR; ROSIGLITAZONE; ROSUVASTATIN; SIMVASTATIN; VALSARTAN; VERLUKAST; VINBLASTINE;

ARTICLE; BILIARY EXCRETION; DRUG CLEARANCE; DRUG EXCRETION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL MEMBRANE; MEMBRANE PERMEABILITY; MEMBRANE VESICLE; MICHAELIS MENTEN KINETICS; PROTEIN CONTENT;

ANIMALS; BENZBROMARONE; BILE; BIOLOGICAL ASSAY; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; HUMANS; INHIBITORY CONCENTRATION 50; MADIN DARBY CANINE KIDNEY CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PREDICTIVE VALUE OF TESTS; RATS; SPECIES SPECIFICITY; TRANSPORT VESICLES;

EID: 84884254160     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.769649     Document Type: Article

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