Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 6696-6708

  Murphy, Jennifer M ^a,b   Armijo, Amanda L ^a   Nomme, Julian ^c   Lee, Chi Hang ^a   Smith, Quentin A ^b   Li, Zheng ^a   Campbell, Dean O ^a,d   Liao, Hsiang I ^a   Nathanson, David A ^a   Austin, Wayne R ^a   Lee, Jason T ^a,e   Darvish, Ryan ^a   Wei, Liu ^a   Wang, Jue ^a   Su, Ying ^c   Damoiseaux, Robert ^b   Sadeghi, Saman ^a   Phelps, Michael E ^a   Herschman, Harvey R ^a   Czernin, Johannes ^a   Alexandrova, Anastassia N ^b   Jung, Michael E ^b   Lavie, Arnon ^c   Radu, Caius G ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d Agensys Inc   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 [4 [[(4,6 DIAMINOPYRIMIDIN 2 YL)THIO]METHYL] 5 PROPYLTHIAZOL 2 YL] 2 METHOXYPHENOXY] 2 METHYLPROPAN2 OL; 2 [[[2 [3 (2 FLUOROETHOXY) 4 METHOXYPHENYL] 5 METHYLTHIAZOL 4 YL]METHYL]THIO]PYRIMIDINE 4,6 DIAMINE; 2 [[[2 [3 (2 FLUOROETHOXY) 4 METHOXYPHENYL] 5 PROPYLTHIAZOL 4 YL]METHYL]THIO]PYRIMIDINE 4,6 DIAMINE; 2 [[[5 ETHYL 2 [3 (2 FLUOROETHOXY) 4 METHOXYPHENYL]THIAZOL 4 YL]METHYL]THIO]PYRIMIDINE 4,6 DIAMINE; DEOXYCYTIDINE KINASE; N [2 [5 [4 [[(4,6 DIAMINOPYRIMIDIN 2 YL)THIO]METHYL] 5 PROPYLTHIAZOL 2 YL] 2 METHOXYPHENOXY]ETHYL]METHANESULFONAMIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG STRUCTURE; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR LIBRARY; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; SINGLE DRUG DOSE; STEADY STATE; STRUCTURE ACTIVITY RELATION;

EID: 84884251443     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400457y     Document Type: Article

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