Protein kinase C modulates Aurora-kinase inhibition induced by CCT129202 in HMC-1560,816 cell line

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Volumn 12, Issue 3, 2013, Pages 265-276

  Tobí, Araceli ^a   Alfonso, Amparo ^a   Fernández Araujo, Andrea ^a   Alonso, Eva ^a   Botana, Luis M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Aurora kinase; Caspases; CCT129202; HMC 1; PKC

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; AURORA KINASE; AURORA KINASE INHIBITOR; CASPASE 3; CASPASE 8; CCT129202; GF109203X; PROTEIN KINASE C; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAST CELL; MITOSIS INHIBITION; WESTERN BLOTTING;

APOPTOSIS; AURORA KINASE A; AURORA KINASES; CARBAZOLES; CASPASE 3; CASPASE 8; CELL CYCLE; CELL LINE; CELL SURVIVAL; HUMANS; IMIDAZOLES; INDOLES; MALEIMIDES; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; TRANSFECTION;

EID: 84884232840     PISSN: 18715230     EISSN: 1875614X     Source Type: Journal    
DOI: 10.2174/18715230113129990002     Document Type: Article

References (60)

1. Valent, P.; Horny, H.P.; Escribano, L.; Longley, B.J.; Li, C.Y.; Schwartz, L.B.; Marone, G.; Nunez, R.; Akin, C.; Sotlar, K.; Sperr, W.R.; Wolff, K.; Brunning, R.D.; Parwaresch, R.M.; Austen, K.F.; Lennert, K.; Metcalfe, D.D.; Vardiman, J.W.; Bennett, J.M., Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res, 2001, 25, (7), 603-625.
2. Shah, N.P.; Lee, F.Y.; Luo, R.; Jiang, Y.; Donker, M.; Akin, C., Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood, 2006, 108, (1), 286-291.
3. Akin, C.; Brockow, K.; D'Ambrosio, C.; Kirshenbaum, A.S.; Ma, Y.; Longley, B.J.; Metcalfe, D.D., Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Experimental hematology, 2003, 31, (8), 686-692.
4. Ma, Y.; Zeng, S.; Metcalfe, D.D.; Akin, C.; Dimitrijevic, S.; Butterfield, J.H.; McMahon, G.; Longley, B.J., The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood, 2002, 99, (5), 1741-1744.
5. Yavuz, A.S.; Lipsky, P.E.; Yavuz, S.; Metcalfe, D.D.; Akin, C., Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood, 2002, 100, (2), 661-665.
6. Garcia-Montero, A.C.; Jara-Acevedo, M.; Teodosio, C.; Sanchez, M.L.; Nunez, R.; Prados, A.; Aldanondo, I.; Sanchez, L.; Dominguez, M.; Botana, L.M.; Sanchez-Jimenez, F.; Sotlar, K.; Almeida, J.; Escribano, L.; Orfao, A., KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood, 2006, 108, (7), 2366-2372.
7. Peng, Z.; Beaven, M.A., An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells. J Immunol, 2005, 174, (9), 5201-5208.
8. Vilarino, N.; de la Rosa, L.A.; Vieytes, M.R.; Botana, L.M., HCO(3)(-) ions modify the role of PKC isoforms in the modulation of rat mast cell functions. Cell Signal, 2001, 13, (3), 177-190.
9. Kanthasamy, A.G.; Kitazawa, M.; Yang, Y.; Anantharam, V.; Kanthasamy, A., Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Molecular brain, 2008, 1, 12.
10. Lewis, A.E.; Susarla, R.; Wong, B.C.; Langman, M.J.; Eggo, M.C., Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. Cellular signalling, 2005, 17, (2), 253-262.
11. Zhang, Y.X.; Yu, S.B.; Ou-Yang, J.P.; Xia, D.; Wang, M.; Li, J.R., Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine. Acta pharmacologica Sinica, 2005, 26, (11), 1365-1372.
12. Matsumura, M.; Tanaka, N.; Kuroki, T.; Ichihashi, M.; Ohba, M., The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes. Biochemical and biophysical research communications, 2003, 303, (1), 350-356.
13. Zermati, Y.; De Sepulveda, P.; Féger, F.; Létard, S.; Kersual, J.; Castéran, N.; Gorochov, G.; Dy, M.; Ribadeau Dumas, A.; Dorgham, K.; Parizot, C.; Bieche, Y.; Vidaud, M.; Lortholary, O.; Arock, M.; Hermine, O.; Dubreuil, P., Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms. Oncogene, 2003, 22, 660-664.
14. Elliott, M.A.; Pardanani, A.; Li, C.Y.; Teffer, i.A., Immunophenotypic normalization of aberrant mast cells accompanies histological remission in imatinib-treated patients with eosinophilia-associated mastocytosis. Leukemia, 2004, 18, 1027-1029.
15. Pardanani, A.; Ketterling, R.P.; Brockman, S.R.; Flynn, H.C.; Paternoster, S.F.; Shearer, B.M.; Reeder, T.L.; Li, C.Y.; Cross, N.C.; Cools, J.; Gilliland, D.G.; Dewald, G.W.; Tefferi, A., CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood, 2003, 102, 3093-3096.
16. Gleixner, K.V.; Mayerhofer, M.; Aichberger, K.J.; Derdak, S.; Sonneck, K.; Bohm, A.; Gruze, A.; Samorapoompichit, P.; Manley, P.W.; Fabbro, D.; Pickl, W.F.; Sillaber, C.; Valent, P., PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood, 2006, 107, (2), 752-759.
17. Pan, J.; Quintás-Cardama, A.; Kantarjian, H.M.; Akin, C.; Manshouri, T.; Lamb, P.; Cortes, J.E.; Tefferi, A.; Giles, F.J.; Verstovsek, S., a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation. Blood, 2006, 109, 315-322.
18. Hannak, E.; Kirkham, M.; Hyman, A.A.; Oegema, K., Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol, 2001, 155, (7), 1109-1116.
19. Meraldi, P.; Honda, R.; Nigg, E.A., Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev, 2004, 14, (1), 29-36.
20. Dutertre, S.; Descamps, S.; Prigent, C., On the role of aurora-A in centrosome function. Oncogene, 2002, 21, (40), 6175-6183.
21. Nigg, E.A., Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol, 2001, 2, (1), 21-32.
22. Adams, R.R.; Carmena, M.; Earnshaw, W.C., Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol, 2001, 11, (2), 49-54.
23. Shannon, K.B.; Salmon, E.D., Chromosome dynamics: new light on Aurora B kinase function. Curr Biol, 2002, 12, (13), R458-460.
24. Hsu, J.Y.; Sun, Z.W.; Li, X.; Reuben, M.; Tatchell, K.; Bishop, D.K.; Grushcow, J.M.; Brame, C.J.; Caldwell, J.A.; Hunt, D.F.; Lin, R.; Smith, M.M.; Allis, C.D., Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell, 2000, 102, (3), 279-291.
25. Katayama, H.; Brinkley, W.R.; Sen, S., The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev, 2003, 22, (4), 451-464.
26. Tang, C.J.; Lin, C.Y.; Tang, T.K., Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev Biol, 2006, 290, (2), 398-410.
27. Bolanos-Garcia, V.M., Aurora kinases. Int J Biochem Cell Biol, 2005, 37, (8), 1572-1577.
28. Harrington, E.A.; Bebbington, D.; Moore, J.; Rasmussen, R.K.; Ajose-Adeogun, A.O.; Nakayama, T.; Graham, J.A.; Demur, C.; Hercend, T.; Diu-Hercend, A.; Su, M.; Golec, J.M.; Miller, K.M., VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med, 2004, 10, (3), 262-267.
29. Huang, X.F.; Luo, S.K.; Xu, J.; Li, J.; Xu, D.R.; Wang, L.H.; Yan, M.; Wang, X.R.; Wan, X.B.; Zheng, F.M.; Zeng, Y.X.; Liu, Q., Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood, 2008, 111, (5), 2854-2865.
30. Ikezoe, T.; Yang, J.; Nishioka, C.; Tasaka, T.; Taniguchi, A.; Kuwayama, Y.; Komatsu, N.; Bandobashi, K.; Togitani, K.; Koeffler, H.P.; Taguchi, H., A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Mol Cancer Ther, 2007, 6, (6), 1851-1857.
31. Mountzios, G.; Terpos, E.; Dimopoulos, M.A., Aurora kinases as targets for cancer therapy. Cancer treatment reviews, 2008, 34, (2), 175-182.
32. Yang, J.; Ikezoe, T.; Nishioka, C.; Tasaka, T.; Taniguchi, A.; Kuwayama, Y.; Komatsu, N.; Bandobashi, K.; Togitani, K.; Koeffler, H.P.; Taguchi, H.; Yokoyama, A., AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood, 2007, 110, (6), 2034-2040.
33. Chan, F.; Sun, C.; Perumal, M.; Nguyen, Q.D.; Bavetsias, V.; McDonald, E.; Martins, V.; Wilsher, N.E.; Raynaud, F.I.; Valenti, M.; Eccles, S.; Te Poele, R.; Workman, P.; Aboagye, E.O.; Linardopoulos, S., Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther, 2007, 6, (12 Pt 1), 3147-3157.
34. Nunez, G.; Benedict, M.A.; Hu, Y.; Inohara, N., Caspases: the proteases of the apoptotic pathway. Oncogene, 1998, 17, (25), 3237-3245.
35. Majumder, P.K.; Pandey, P.; Sun, X.; Cheng, K.; Datta, R.; Saxena, S.; Kharbanda, S.; Kufe, D., Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. The Journal of biological chemistry, 2000, 275, (29), 21793-21796.
36. Park, I.C.; Park, M.J.; Rhee, C.H.; Lee, J.I.; Choe, T.B.; Jang, J.J.; Lee, S.H.; Hong, S.I., Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line. International journal of oncology, 2001, 18, (5), 1077-1083.
37. Pernas-Sueiras, O.; Alfonso, A.; Vieytes, M.R.; Botana, L.M., PKC and cAMP positively modulate alkaline-induced exocytosis in the human mast cell line HMC-1. Journal of cellular biochemistry, 2006, 99, (6), 1651-1663.
38. Lober, K.; Alfonso, A.; Escribano, L.; Botana, L.M., STI571 (Glivec(R)) affects histamine release and intracellular pH after alkalinisation in HMC-1(560, 816). J Cell Biochem, 2008, 103, (3), 865-876.
39. Lober, K.; Alfonso, A.; Escribano, L.; Botana, L.M., Influence of the tyrosine kinase inhibitors STI571 (Glivec(R)), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem, 2008, 103, (4), 1076-1088.
40. Martiny-Baron, G.; Kazanietz, M.G.; Mischak, H.; Blumberg, P.M.; Kochs, G.; Hug, H.; Marme, D.; Schachtele, C., Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem, 1993, 268, (13), 9194-9197.
41. Pongracz, J.; Webb, P.; Wang, K.; Deacon, E.; Lunn, O.J.; Lord, J.M., Spontaneous neutrophil apoptosis involves caspase 3- mediated activation of protein kinase C-delta. The Journal of biological chemistry, 1999, 274, (52), 37329-37334.
42. Koriyama, H.; Kouchi, Z.; Umeda, T.; Saido, T.C.; Momoi, T.; Ishiura, S.; Suzuki, K., Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cellular signalling, 1999, 11, (11), 831-838.
43. Bharti, A.; Kraeft, S.K.; Gounder, M.; Pandey, P.; Jin, S.; Yuan, Z.M.; Lees-Miller, S.P.; Weichselbaum, R.; Weaver, D.; Chen, L.B.; Kufe, D.; Kharbanda, S., Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Molecular and cellular biology, 1998, 18, (11), 6719-6728.
44. Yoshida, K., PKCdelta signaling: mechanisms of DNA damage response and apoptosis. Cell Signal, 2007, 19, (5), 892-901.
45. Alonso, E.; Alfonso, A.; Lober, K.; Botana, L.M., The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. J Cell Biochem, 2008, 105, (1), 255-261.
46. Tobio, A.; Alfonso, A.; Botana, L.M., C-kit mutations and PKC crosstalks: PKC translocates to nucleous only in cells HMC,(1). Journal of cellular biochemistry, 2011, 112, (9), 2637-2651.
47. Tan, S.L.; Parker, P.J., Emerging and diverse roles of protein kinase C in immune cell signalling. The Biochemical journal, 2003, 376, (Pt 3), 545-552.
48. Blank, U.; Rivera, J., The ins and outs of IgE-dependent mast-cell exocytosis. Trends in immunology, 2004, 25, (5), 266-273.
49. Liu, Y.; Graham, C.; Parravicini, V.; Brown, M.J.; Rivera, J.; Shaw, S., Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling. J Leukoc Biol, 2001, 69, (5), 831-840.
50. Pongracz, J.; Webb, P.; Wang, K.; Deacon, E.; Lunn, O.J.; Lord, J.M., Spontaneous neutrophil apoptosis involves caspase 3- mediated activation of protein kinase C-delta. The Journal of biological chemistry, 1999, 274, (52), 37329-37334.
51. Koriyama, H.; Kouchi, Z.; Umeda, T.; Saido, T.C.; Momoi, T.; Ishiura, S.; Suzuki, K., Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cellular signalling, 1999, 11, (11), 831-838.
52. Emoto, Y.; Manome, Y.; Meinhardt, G.; Kisaki, H.; Kharbanda, S.; Robertson, M.; Ghayur, T.; Wong, W.W.; Kamen, R.; Weichselbaum, R.; et al., Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. The EMBO journal, 1995, 14, (24), 6148-6156.
53. Datta, R.; Kojima, H.; Yoshida, K.; Kufe, D., Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. The Journal of biological chemistry, 1997, 272, (33), 20317-20320.
54. Eitel, K.; Staiger, H.; Rieger, J.; Mischak, H.; Brandhorst, H.; Brendel, M.D.; Bretzel, R.G.; Haring, H.U.; Kellerer, M., Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes, 2003, 52, (4), 991-997.
55. Leng, L.; Du, B.; Consigli, S.; McCaffrey, T.A., Translocation of protein kinase C-delta by PDGF in cultured vascular smooth muscle cells: inhibition by TGF-beta 1. Artery, 1996, 22, (3), 140-154.
56. Scheel-Toellner, D.; Pilling, D.; Akbar, A.N.; Hardie, D.; Lombardi, G.; Salmon, M.; Lord, J.M., Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta. Eur J Immunol, 1999, 29, (8), 2603-2612.
57. Aichberger, K.J.; Gleixner, K.V.; Mirkina, I.; Cerny-Reiterer, S.; Peter, B.; Ferenc, V.; Kneidinger, M.; Baumgartner, C.; Mayerhofer, M.; Gruze, A.; Pickl, W.F.; Sillaber, C.; Valent, P., Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs. Blood, 2009, 114, (26), 5342-5351.
58. Aichberger, K.J.; Mayerhofer, M.; Gleixner, K.V.; Krauth, M.T.; Gruze, A.; Pickl, W.F.; Wacheck, V.; Selzer, E.; Mullauer, L.; Agis, H.; Sillaber, C.; Valent, P., Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood, 2007, 109, (7), 3031-3041.
59. Westerberg, C.M.; Hagglund, H.; Nilsson, G., Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation. Cell death & disease, 2012, 3, e417.
60. Astsaturov, I.; Ratushny, V.; Sukhanova, A.; Einarson, M.B.; Bagnyukova, T.; Zhou, Y.; Devarajan, K.; Silverman, J.S.; Tikhmyanova, N.; Skobeleva, N.; Pecherskaya, A.; Nasto, R.E.; Sharma, C.; Jablonski, S.A.; Serebriiskii, I.G.; Weiner, L.M.; Golemis, E.A., Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Science signaling, 2010, 3, (140), ra67.