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Volumn 37, Issue 4, 2013, Pages 217-224

Identification of novel drug targets for the treatment of diabetic retinopathy

Author keywords

Angiopoietins; Diabetic macular edema; Diabetic retinopathy; Neoangiogenesis; PlexinD1; RhoJ; Sema3E

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; VASCULOTROPIN INHIBITOR;

EID: 84884230968     PISSN: 22336079     EISSN: 22336087     Source Type: Journal    
DOI: 10.4093/dmj.2013.37.4.217     Document Type: Article
Times cited : (4)

References (50)
  • 4
    • 33847404037 scopus 로고    scopus 로고
    • Fibrosis and diseases of the eye
    • Friedlander M. Fibrosis and diseases of the eye. J Clin Invest 2007;117:576-86.
    • (2007) J Clin Invest , vol.117 , pp. 576-86
    • Friedlander, M.1
  • 6
    • 84867096307 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema: a report by the American Academy of Ophthalmology
    • Ho AC, Scott IU, Kim SJ, Brown GC, Brown MM, Ip MS, Recchia FM. Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema: a report by the American Academy of Ophthalmology. Ophthalmology 2012;119:2179-88.
    • (2012) Ophthalmology , vol.119 , pp. 2179-88
    • Ho, A.C.1    Scott, I.U.2    Kim, S.J.3    Brown, G.C.4    Brown, M.M.5    Ip, M.S.6    Recchia, F.M.7
  • 9
    • 33344467865 scopus 로고    scopus 로고
    • Angiogenesis in the mouse retina: a model system for experimental manipulation
    • Uemura A, Kusuhara S, Katsuta H, Nishikawa S. Angiogenesis in the mouse retina: a model system for experimental manipulation. Exp Cell Res 2006;312:676-83.
    • (2006) Exp Cell Res , vol.312 , pp. 676-83
    • Uemura, A.1    Kusuhara, S.2    Katsuta, H.3    Nishikawa, S.4
  • 10
    • 33947330375 scopus 로고    scopus 로고
    • Development of the retinal vasculature
    • Fruttiger M. Development of the retinal vasculature. Angiogenesis 2007;10:77-88.
    • (2007) Angiogenesis , vol.10 , pp. 77-88
    • Fruttiger, M.1
  • 12
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the pre formed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the pre formed endothelial network and is regulated by PDGF-B and VEGF. Development 1998;125:1591-8.
    • (1998) Development , vol.125 , pp. 1591-8
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 13
    • 0036152086 scopus 로고    scopus 로고
    • Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis
    • Fruttiger M. Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis. Invest Ophthalmol Vis Sci 2002;43:522-7.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 522-7
    • Fruttiger, M.1
  • 14
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997;277:242-5.
    • (1997) Science , vol.277 , pp. 242-5
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 15
    • 0028059309 scopus 로고
    • Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    • Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 1994;8:1888-96.
    • (1994) Genes Dev , vol.8 , pp. 1888-96
    • Soriano, P.1
  • 16
    • 0027936261 scopus 로고
    • Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
    • Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev 1994;8: 1875-87.
    • (1994) Genes Dev , vol.8 , pp. 1875-87
    • Leveen, P.1    Pekny, M.2    Gebre-Medhin, S.3    Swolin, B.4    Larsson, E.5    Betsholtz, C.6
  • 25
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009;10:165-77.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 165-77
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 26
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
    • Oh H, Takagi H, Suzuma K, Otani A, Matsumura M, Honda Y. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999;274:15732-9.
    • (1999) J Biol Chem , vol.274 , pp. 15732-9
    • Oh, H.1    Takagi, H.2    Suzuma, K.3    Otani, A.4    Matsumura, M.5    Honda, Y.6
  • 27
    • 0032547764 scopus 로고    scopus 로고
    • Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
    • Mandriota SJ, Pepper MS. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 1998;83:852-9.
    • (1998) Circ Res , vol.83 , pp. 852-9
    • Mandriota, S.J.1    Pepper, M.S.2
  • 29
    • 84856694670 scopus 로고    scopus 로고
    • Targeting the angiopoietin/Tie2 pathway: cutting tumor vessels with a double-edged sword
    • Cascone T, Heymach JV. Targeting the angiopoietin/Tie2 pathway: cutting tumor vessels with a double-edged sword. J Clin Oncol 2012;30:441-4.
    • (2012) J Clin Oncol , vol.30 , pp. 441-4
    • Cascone, T.1    Heymach, J.V.2
  • 30
    • 80054737355 scopus 로고    scopus 로고
    • Panretinal photocoagulation for proliferative diabetic retinopathy
    • Bressler NM, Beck RW, Ferris FL 3rd. Panretinal photocoagulation for proliferative diabetic retinopathy. N Engl J Med 2011;365:1520-6.
    • (2011) N Engl J Med , vol.365 , pp. 1520-6
    • Bressler, N.M.1    Beck, R.W.2    Ferris, F.L.3
  • 31
    • 80052111842 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of clinical outcomes of vitrectomy with or without intravitreal bevacizumab pretreatment for severe diabetic retinopathy
    • Zhao LQ, Zhu H, Zhao PQ, Hu YQ. A systematic review and meta-analysis of clinical outcomes of vitrectomy with or without intravitreal bevacizumab pretreatment for severe diabetic retinopathy. Br J Ophthalmol 2011;95:1216-22.
    • (2011) Br J Ophthalmol , vol.95 , pp. 1216-22
    • Zhao, L.Q.1    Zhu, H.2    Zhao, P.Q.3    Hu, Y.Q.4
  • 32
    • 0023886270 scopus 로고
    • Retinal astrocytes are immigrants from the optic nerve
    • Watanabe T, Raff MC. Retinal astrocytes are immigrants from the optic nerve. Nature 1988;332:834-7.
    • (1988) Nature , vol.332 , pp. 834-7
    • Watanabe, T.1    Raff, M.C.2
  • 33
    • 0028141655 scopus 로고
    • Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression
    • Jiang B, Liou GI, Behzadian MA, Caldwell RB. Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression. J Cell Sci 1994;107(Pt 9):2499-508.
    • (1994) J Cell Sci , vol.107 , Issue.PART 9 , pp. 2499-508
    • Jiang, B.1    Liou, G.I.2    Behzadian, M.A.3    Caldwell, R.B.4
  • 34
    • 0023192574 scopus 로고
    • Retinal astrocytes: their restriction to vascularized parts of the mammalian retina
    • Schnitzer J. Retinal astrocytes: their restriction to vascularized parts of the mammalian retina. Neurosci Lett 1987;78:29-34.
    • (1987) Neurosci Lett , vol.78 , pp. 29-34
    • Schnitzer, J.1
  • 35
    • 0024205059 scopus 로고
    • Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels
    • Schnitzer J. Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels. Glia 1988;1:74-89.
    • (1988) Glia , vol.1 , pp. 74-89
    • Schnitzer, J.1
  • 37
    • 32444434289 scopus 로고    scopus 로고
    • Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes
    • Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 2006;116:369-77.
    • (2006) J Clin Invest , vol.116 , pp. 369-77
    • Uemura, A.1    Kusuhara, S.2    Wiegand, S.J.3    Yu, R.T.4    Nishikawa, S.5
  • 41
    • 79960018388 scopus 로고    scopus 로고
    • Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism
    • Kim J, Oh WJ, Gaiano N, Yoshida Y, Gu C. Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev 2011; 25:1399-411.
    • (2011) Genes Dev , vol.25 , pp. 1399-411
    • Kim, J.1    Oh, W.J.2    Gaiano, N.3    Yoshida, Y.4    Gu, C.5
  • 43
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: new insights into their functions from in vivo studies
    • Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008;9:690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 44
    • 0842308307 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38
    • Lamalice L, Houle F, Jourdan G, Huot J. Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 2004;23: 434-45.
    • (2004) Oncogene , vol.23 , pp. 434-45
    • Lamalice, L.1    Houle, F.2    Jourdan, G.3    Huot, J.4
  • 45
    • 0037242248 scopus 로고    scopus 로고
    • Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth
    • Abe T, Kato M, Miki H, Takenawa T, Endo T. Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J Cell Sci 2003;116 (Pt 1):155-68.
    • (2003) J Cell Sci , vol.116 , Issue.PART 1 , pp. 155-68
    • Abe, T.1    Kato, M.2    Miki, H.3    Takenawa, T.4    Endo, T.5
  • 47
    • 34249018367 scopus 로고    scopus 로고
    • GEFs and GAPs: critical elements in the control of small G proteins
    • Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 2007;129:865-77.
    • (2007) Cell , vol.129 , pp. 865-77
    • Bos, J.L.1    Rehmann, H.2    Wittinghofer, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.