Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kusuhara, Sentaro ^a,b   Fukushima, Yoko ^a,b,c   Fukuhara, Shigetomo ^d   Jakt, Lars Martin ^a   Okada, Mitsuhiro ^a   Shimizu, Yuri ^a   Hata, Masayuki ^b   Nishida, Kohji ^c   Negi, Akira ^b   Hirashima, Masanori ^b   Mochizuki, Naoki ^d   Nishikawa, Shin Ichi ^a   Uemura, Akiyoshi ^a,b  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN CDC42; PROTEIN RHOJ; RHO FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ACTIN POLYMERIZATION; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CELL MOTILITY; CELL SPECIFICITY; COMPUTER MODEL; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE ACTIVITY; GENE DISRUPTION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCATION; HUMAN; HUMAN CELL; MALE; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; RETINA BLOOD VESSEL; RETINA DEVELOPMENT; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR GENE;

ACTINS; ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELLS, CULTURED; FEMALE; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN MULTIMERIZATION; RETINA; RETINAL VESSELS; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 84866660544     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045858     Document Type: Article

References (36)

1. Risau W, (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
2. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, et al. (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355: 1419-1431.
3. Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, et al. (2011) Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med 364: 1897-1908.
4. Mintz-Hittner HA, Kennedy KA, Chuang AZ, (2011) Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 364: 603-615.
5. Yang X, Cepko CL, (1996) Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci 16: 6089-6099.
6. Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, et al. (2008) Endogenous VEGF is required for visual function: evidence for a survival role on muller cells and photoreceptors. PLoS One 3: e3554.
7. Nishijima K, Ng YS, Zhong L, Bradley J, Schubert W, et al. (2007) Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol 171: 53-67.
8. Heasman SJ, Ridley AJ, (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9: 690-701.
9. Lamalice L, Houle F, Jourdan G, Huot J, (2004) Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 23: 434-445.
10. Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, et al. (2011) Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest 121: 1974-1985.
11. Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, et al. (2000) Characterization of TCL, a new GTPase of the rho family related to TC10 and Cdc42. J Biol Chem 275: 36457-36464.
12. Abe T, Kato M, Miki H, Takenawa T, Endo T, (2003) Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J Cell Sci 116: 155-168.
13. Bos JL, Rehmann H, Wittinghofer A, (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129: 865-877.
14. Lazer G, Katzav S, (2011) Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy? Cell Signal 23: 969-979.
15. Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M, et al. (2003) EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res 93: 23-31.
16. Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, et al. (2010) EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell 143: 442-455.
17. Fruttiger M, (2007) Development of the retinal vasculature. Angiogenesis 10: 77-88.
18. Uemura A, Kusuhara S, Katsuta H, Nishikawa S, (2006) Angiogenesis in the mouse retina: a model system for experimental manipulation. Exp Cell Res 312: 676-683.
19. Tusher VG, Tibshirani R, Chu G, (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121.
20. Mills JC, Roth KA, Cagan RL, Gordon JI, (2001) DNA microarrays and beyond: completing the journey from tissue to cell. Nat Cell Biol 3: E175-178.
21. Jakt LM, Nishikawa S, (2008) DNA chip databases, omics, and gene fishing: commentary. Cancer Sci 99: 829-835.
22. Rossman KL, Der CJ, Sondek J, (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180.
23. Mogilner A, Keren K, (2009) The shape of motile cells. Curr Biol 19: R762-771.
24. McCormick SM, Eskin SG, McIntire LV, Teng CL, Lu CM, et al. (2001) DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci U S A 98: 8955-8960.
25. Herbert JM, Stekel D, Sanderson S, Heath VL, Bicknell R, (2008) A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes. BMC Genomics 9: 153.
26. Wallgard E, Larsson E, He L, Hellstrom M, Armulik A, et al. (2008) Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol 28: 1469-1476.
27. del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, et al. (2010) Identification and functional analysis of endothelial tip cell-enriched genes. Blood 116: 4025-4033.
28. Strasser GA, Kaminker JS, Tessier-Lavigne M, (2010) Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood 115: 5102-5110.
29. Kurogane Y, Miyata M, Kubo Y, Nagamatsu Y, Kundu RK, et al. (2012) FGD5 Mediates Proangiogenic Action of Vascular Endothelial Growth Factor in Human Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol 32: 988-996.
30. Motoike T, Loughna S, Perens E, Roman BL, Liao W, et al. (2000) Universal GFP reporter for the study of vascular development. Genesis 28: 75-81.
31. Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, et al. (2008) Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and-independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development 135: 755-765.
32. Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, et al. (1993) A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem 214: 70-76.
33. Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, et al. (2006) Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 172: 151-162.
34. Takebe A, Era T, Okada M, Martin Jakt L, Kuroda Y, et al. (2006) Microarray analysis of PDGFR alpha+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. Dev Biol 293: 25-37.
35. Li C, Wong WH, (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 98: 31-36.
36. Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S, (2006) Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 116: 369-377.