Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysis

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 6985-6990

  Stepan, Antonia F ^a   Kauffman, Gregory W ^a   Keefer, Christopher E ^a   Verhoest, Patrick R ^a   Edwards, Martin ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ETHER DERIVATIVE;

ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DEVELOPMENT; DRUG METABOLISM; DRUG SOLUBILITY; IC 50; LIPOPHILICITY; MOLECULAR SIZE; MOLECULAR WEIGHT;

CYTOCHROME P-450 ENZYME SYSTEM; ETHERS;

EID: 84884230698     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4008642     Document Type: Article

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25. Values for clogP were calculated using the BIOBYTE (www.biobyte.com) program clogP, version 4.3.