Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis

Annals of Neurology

Volumn 67, Issue 4, 2010, Pages 470-478

  Malter, Michael P ^a   Helmstaedter, Christoph ^a   Urbach, Horst ^a   Vincent, Angela ^b   Bien, Christian G ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN G; IODINE 125; METHYLPREDNISOLONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

ADULT; ANTIBODY TITER; ARTICLE; BRAIN FUNCTION; CEREBROSPINAL FLUID EXAMINATION; FOLLOW UP; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PARANEOPLASTIC NEUROPATHY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SEIZURE; STEROID THERAPY; TEMPORAL LOBE EPILEPSY; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; FEMALE; FLUORODEOXYGLUCOSE F18; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; LIMBIC ENCEPHALITIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; POTASSIUM CHANNELS, VOLTAGE-GATED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77951740941     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21917     Document Type: Article

References (41)

1. Brierley JB, Corsellis JAN, Hierons R, et al. Subacute encephalitis of later adult life mainly affecting the limbic areas. Brain 1960; 83:357-368.
2. Corsellis JA, Goldberg GJ, Norton AR. "Limbic encephalitis" and its association with carcinoma. Brain 1968;91:481-496.
3. Gultekin SH, Rosenfeld MR, Voltz R, et al. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 2000;123:1481-1494. (Pubitemid 30420947)
4. Bien CG, Schulze-Bonhage A, Deckert M, et al. Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy. Neurology 2000;55:1823-1828. (Pubitemid 32103963)
5. Vincent A, Buckley C, Schott JM, et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127:701-712. (Pubitemid 38295483)
6. Graus F, Delattre JY, Antoine JC, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-1140. (Pubitemid 39005770)
7. Saiz A, Blanco Y, Sabater L, et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 2008; 131(pt 10):2553-2563.
8. Mazzi G, Roia DD, Cruciatti B, et al. Plasma exchange for anti-GAD associated non paraneoplastic limbic encephalitis. Transfus Apher Sci 2008;39:229-233.
9. Matà S, Muscas GC, Naldi I, et al. Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies. J Neuroimmunol 2008;199:155-159.
10. Giometto B, Nicolao P, Macucci M, et al. Temporal-lobe epilepsy associated with glutamic-acid- decarboxylase autoantibodies [letter]. Lancet 1998;352:457. (Pubitemid 28362802)
11. Solimena M, Folli F, Denis-Donini S, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med 1988;318: 1012-1020. (Pubitemid 18095005)
12. Marnane M, Vincent A, Hutchinson M. New-onset focal epilepsy with palatal tremor and glutamic acid decarboxylase antibodies responding to intravenous immunoglobulin. J Neurol 2008;255: 1603-1604.
13. Baekkeskov S, Aanstoot HJ, Christgau S, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347:151-156; erratum, 1990;347:782.
14. McKnight K, Jiang Y, Hart Y, et al. Serum antibodies in epilepsy and seizure-associated disorders. Neurology 2005;65:1730-1736. (Pubitemid 43754401)
15. Honnorat J, Saiz A, Giometto B, et al. Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol 2001;58:225-230. (Pubitemid 32163159)
16. Peltola J, Kulmala P, Isojärvi J, et al. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology 2000;55:46-50. (Pubitemid 30460996)
17. Kwan P, Sills GJ, Kelly K, et al. Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Res 2000;42:191-195.
18. Bien CG, Urbach H, Schramm J, et al. Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology 2007;69:1236-1244. (Pubitemid 47429024)
19. Niehusmann P, Dalmau J, Rudlowski C, et al. Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy. Arch Neurol 2009;66:458-464.
20. Soeder BM, Gleissner U, Urbach H, et al. Causes, presentation and outcome of lesional adult-onset mediotemporal lobe epilepsy. J Neurol Neurosurg Psychiatry 2009;80:888-893.
21. Hart IK, Waters C, Vincent A, et al. Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia. Ann Neurol 1997;41:238-246. (Pubitemid 27082105)
22. Dale RC, Irani S, Brilot F, et al. N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol 2009;66:704-709.
23. Dalmau J, Tüzün E, Wu HY, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 2007;61:25-36. (Pubitemid 46214241)
24. Dalakas MC, Li M, Fujii M, et al. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 2001;57:780-784. (Pubitemid 32845494)
25. Rakocevic G, Raju R, Semino-Mora C, et al. Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. Neurology 2006;67:1068-1070. (Pubitemid 44454608)
26. Rakocevic G, Raju R, Dalakas MC. Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch Neurol 2004;61:902-904. (Pubitemid 38747330)
27. Langhoff E, Ladefoged J. Relative immunosuppressive potency of various corticosteroids measured in vitro. Eur J Clin Pharmacol 1983;25:459-462. (Pubitemid 14234278)
28. Urbach H. Imaging of the epilepsies. Eur Radiol 2005;15: 494-500.
29. Helmstaedter C, Lendt M, Lux S. VLMT: Verbaler Lern- und Merkfähigkeitstest. Testhandbuch. Göttingen, Germany: Hogrefe, 2000.
30. Helmstaedter C, Pohl C, Elger CE. Eine modifizierte Version des Diagnostikums für Cerebralschäden (DCS) zur Diagnostik räumlich-visueller Gedächtnisdefizite bei Patienten mit Temporallappenepilepsie. In: Scheffner D, ed. Epilepsie 90. Reinbek, Germany: Einhorn-Presse, 1991:272-279.
31. Bien CG, Bauer J, Deckwerth TL, et al. Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis. Ann Neurol 2002;51:311-318. (Pubitemid 34206287)
32. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008;7:1091-1098.
33. Scheid R, Lincke T, Voltz R, et al. Serial 18F-fluoro-2-deoxy-Dglucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis. Arch Neurol 2004; 61:1785-1789. (Pubitemid 39463437)
34. Dalakas MC, Fujii M, Li M, et al. High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med 2001;345: 1870-1876. (Pubitemid 33716561)
35. Graus F, Saiz A, Lai M, et al. Neuronal surface antigen antibodies in limbic encephalitis: Clinical-immunologic associations. Neurology 2008;71:930-936.
36. Vincent A. Stiff, twitchy or wobbly: are GAD antibodies pathogenic? Brain 2008;131:2536-2537.
37. Reetz A, Solimena M, Matteoli M, et al. GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J 1991;10:1275-1284. (Pubitemid 21905590)
38. Christgau S, Aanstoot HJ, Schierbeck H, et al. Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. J Cell Biol 1992;118:309-320.
39. Manto MU, Laute MA, Aguera M, et al. Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol 2007;61:544-551. (Pubitemid 47068136)
40. Vianello M, Bisson G, Dal MM, et al. Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies. Autoimmunity 2008;41:66-73.
41. Reiber H. Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases. Mult Scler 1998;4:99-107. (Pubitemid 28410032)