Bisphosphonates inhibit expression of p63 by oral keratinocytes

Journal of Dental Research

Volumn 90, Issue 7, 2011, Pages 894-899

  Scheller, E L ^a   Baldwin, C M ^a   Kuo, S ^c   D'Silva, N J ^a,b   Feinberg, S E ^c   Krebsbach, P H ^a   Edwards, P C ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

Epithelia; Gingival; Keratinocytes; Oral pathology; Osteonecrosis; Zoledronic acid

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; CKAP4 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; MEMBRANE PROTEIN; MEVALONIC ACID; SMALL INTERFERING RNA; ZOLEDRONIC ACID;

ADULT STEM CELL; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; BONE NECROSIS; CASE CONTROL STUDY; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE EXPRESSION; GENE SILENCING; GENETICS; HUMAN; JAW DISEASE; KERATINOCYTE; METABOLISM; TISSUE CULTURE TECHNIQUE; WOUND HEALING;

ADULT STEM CELLS; ANALYSIS OF VARIANCE; BONE DENSITY CONSERVATION AGENTS; CASE-CONTROL STUDIES; CELL LINE, TRANSFORMED; DIPHOSPHONATES; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMIDAZOLES; JAW DISEASES; KERATINOCYTES; MEMBRANE PROTEINS; MEVALONIC ACID; OSTEONECROSIS; RNA, SMALL INTERFERING; TISSUE CULTURE TECHNIQUES; WOUND HEALING;

EID: 84884211332     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034511407918     Document Type: Article

References (30)

1. Amagase K, Hayashi S, Nishikawa K, Aihara E, Takeuchi K (2007). Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. Dig Dis Sci 52:1879-1889. (Pubitemid 47024679)
2. Bergström JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G (2000). Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys 373:231-241. (Pubitemid 30046509)
3. Bortoluzzi MC, Yurgel LS, Dekker NP, Jordan RC, Regezi JA (2004). Assessment of p63 expression in oral squamous cell carcinomas and dysplasias. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:698-704. (Pubitemid 39610457)
4. Castilho RM, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind JS (2010). Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One 5:e10503.
5. Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, et al. (1999). Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci USA 96:133-138. (Pubitemid 29036065)
6. Giraudo E, Inoue M, Hanahan D (2004). An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114:623-633. (Pubitemid 39578752)
7. Gonzalez-Moles MA, Bagan-Sebastian JV (2000). Alendronate-related oral mucosa ulcerations. J Oral Pathol Med 29:514-518.
8. Izumi K, Takacs G, Terashi H, Feinberg SE (1999). Ex vivo development of a composite human oral mucosal equivalent. J Oral Maxillofac Surg 57:571-577. (Pubitemid 29214252)
9. Izumi K, Feinberg SE, Iida A, Yoshizawa M (2003). Intraoral grafting of an ex vivo produced oral mucosa equivalent: a preliminary report. Int J Oral Maxillofac Surg 32:188-197. (Pubitemid 36592572)
10. Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, et al. (2004). A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci USA 101:12479-12484. (Pubitemid 39122049)
11. Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, et al. (2010). Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice. J Bone Miner Metab 28:165-175.
12. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR (2004). p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 18:126-131. (Pubitemid 38141780)
13. Landesberg R, Cozin M, Cremers S, Woo V, Kousteni S, Sinha S, et al. (2008). Inhibition of oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg 66:839-847. (Pubitemid 351522817)
14. Little NA, Jochemsen AG (2002). p63. Int J Biochem Cell Biol 34:6-9.
15. Luckman SP, Coxon FP, Ebetino FH, Russell RG, Rogers MJ (1998). Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res 13:1668-1678. (Pubitemid 28491995)
16. Marx RE, Sawatari Y, Fortin M, Broumand V (2005). Bisphosphonateinduced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 63:1567-1575.
17. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398:708-713. (Pubitemid 29197649)
18. Monkkonen H, Tormalehto S, Asunmaa K, Niemi R, Auriola S, Vepsalainen J, et al. (2003). Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonateinduced gastrointestinal side-effects. Eur J Pharm Sci 19:23-29. (Pubitemid 36506934)
19. Novince CM, Ward BB, McCauley LK (2009). Osteonecrosis of the jaw: an update and review of recommendations. Cells Tissues Organs 189:275-283.
20. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, et al. (2001). p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98:3156-3161. (Pubitemid 32220815)
21. Rubegni P, Fimiani M (2006). Images in clinical medicine. Bisphosphonate-associated contact stomatitis. N Engl J Med 355:e25. (Pubitemid 44837775)
22. Scheller EL, Song J, Dishowitz MI, Soki FN, Hankenson KD, Krebsbach PH (2010). Leptin functions peripherally to regulate differentiation of mesenchymal progenitor cells. Stem Cells 28:1071-1080.
23. Senoo M, Pinto F, Crum CP, McKeon F (2007). p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129:523-536. (Pubitemid 46660965)
24. Stephens P, Genever P (2007). Non-epithelial oral mucosal progenitor cell populations. Oral Dis 13:1-10. (Pubitemid 46046528)
25. Suri S, Monkkonen J, Taskinen M, Pesonen J, Blank MA, Phipps RJ, et al. (2001). Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone 29:336-343. (Pubitemid 32930060)
26. Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW (2009). H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. PLoS One 4:e7908.
27. Warburton G, Nares S, Angelov N, Brahim JS, Dionne RA, Wahl SM (2005). Transcriptional events in a clinical model of oral mucosal tissue injury and repair. Wound Repair Regen 13:19-26. (Pubitemid 40250426)
28. Woo SB, Hellstein JW, Kalmar JR (2006). Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 144:753-761; (Pubitemid 46780635)
29. erratum in Ann Intern Med 145:325, 2006.
30. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, et al. (1999). p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714-718. (Pubitemid 29197650)