Design, synthesis, and biological evaluation of cyclopropyl analogues of stilbene with raloxifene side chain as subtype-selective ligands for estrogen receptor

Archives of Pharmacal Research

Volumn 36, Issue 9, 2013, Pages 1096-1103

  Yeo, Hye Lim ^a   Song, Yoon Sun ^a   Ryu, Jae Ha ^a   Kim, Hee Doo ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Binding affinity; Cyclopropane; Estrogen receptor; Gene transcription assay; Stilbene; Subtype selective ligand

Indexed keywords

2 (4 METHOXYPHENYL) 3 (4 PHENOXYLMETHYLPHENYL) PROPENAL; 2 [4 (BENZYLOXY)PHENYL] 1 (4 METHOXYPHENYL) CYCLOPROPANECARBALDEHYDE; 3 (4 BENZYLOXYPHENYL) 2 (4 METHOXYPHENYL) ACRYLONITRILE; 3 (4 BENZYLOXYPHENYL) 2 (4 METHOXYPHENYL)PROP 2 EN 1 OL; 4 [2 (4 METHOXYPHENYL) 2 METHYLCYCLOPROPYL]PHENOL; 4,4' (1 METHYLCYCLOPROPANE 1,2 DIYL)DIPHENOL; [1 2 BIS(4 HYDROXYPHENYL)CYCLOPROPYL][4 (2 (PIPERIDIN 1 YL)ETHOXY)PHENYL]METHANONE; [2 (4 (BENZYLOXY)PHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYL][4 (2 PIPERIDIN 1 YL)ETHOXY PHENYL]METHANONE; [2 (4 (BENZYLOXY)PHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYL][4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]METHANOL; [2 (4 HYDROXYPHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYL][4 (2 (PIPERIDIN 1 YL)ETHOXY)PHENYL]METHANONE; [2 4 (BENZYLOXYPHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYL] 2 METHANE; [2 4 (BENZYLOXYPHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYL]METHANOL; CYCLOPROPANE DERIVATIVE; DESS MARTIN PERIODINANE; DITHIOCARBONIC ACID O [2 (4 BENZYLOXYPHENYL) 1 (4 METHOXYPHENYL) CYCLOPROPYLMETHYL ] ESTER METHYL ESTER; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STILBENE DERIVATIVE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG PURIFICATION; DRUG SYNTHESIS; GENETIC TRANSCRIPTION; INFRARED RADIATION; NONHUMAN; OPTICAL ROTATION; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; XENOPUS LAEVIS;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; DRUG DESIGN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; GENES, REPORTER; HUMANS; LIGANDS; MOLECULAR STRUCTURE; RALOXIFENE; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884205885     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0134-2     Document Type: Article

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