Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect

Phytomedicine

Volumn 20, Issue 13, 2013, Pages 1172-1179

  Xu, Lingyuan ^a   Zheng, Ni ^c   He, Qiaoling ^c   Li, Rong ^b   Zhang, Kefeng ^b   Liang, Tao ^c  

^a Department of Medical Laboratory Hospital of Youjiang Medical University for Nationalities   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Hepatic stellate cell; Liver fibrosis; Pueraria lobata; Puerarin; TGF 1 Smad pathway

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; COLLAGEN TYPE 4; DIMETHYLNITROSAMINE; HYALURONIC ACID; HYDROXYPROLINE; INTERSTITIAL COLLAGENASE; LAMININ; PROCOLLAGEN; PUERARIN; SILYMARIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; LIVER CELL; LIVER FIBROSIS; LIVER HOMOGENATE; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERARIA LOBATA; RANDOMIZED CONTROLLED TRIAL; RAT; STELLATE CELL; TREATMENT DURATION;

PUERARIA MONTANA VAR. LOBATA; RATTUS;

HEPATIC STELLATE CELL; LIVER FIBROSIS; PUERARIA LOBATA; PUERARIN; TGF-Β1/SMAD PATHWAY;

ANIMALS; CELL LINE; DIMETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEPATOCYTES; ISOFLAVONES; LIVER; LIVER CIRRHOSIS; MALE; MOLECULAR STRUCTURE; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84884203817     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.06.008     Document Type: Article

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