Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 756, Issue 1-2, 2013, Pages 119-126

  Olme, C H ^a   Brown, N ^a   Finnon, R ^a   Bouffler, S D ^a   Badie, C ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Chromosome deletion; Mouse model; Myeloid leukaemia; Radiation; Sfpi1 PU.1; Stem cells

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL POPULATION; CHROMOSOME 2; CHROMOSOME DAMAGE; CHROMOSOME DELETION; COLONY FORMING UNIT; CONTROLLED STUDY; EX VIVO STUDY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; REPORTER GENE; X RAY;

7-AAD; 7-AMINOACTINOMYCIN D; BAC-FISH; BACTERIAL ARTIFICIAL CHROMOSOME-FLUORESCENT IN SITU HYBRIDISATION; BMCS; BONE MARROW CELLS; CANCER STEM CELL; CFU-S12; CHROMOSOME DELETION; CMP; COLONY FORMING UNIT SPLEEN ON DAY 12; COMMON MYELOID PROGENITOR; CSC; DEL2; GFP; GREEN FLUORESCENT PROTEIN; HAEMATOPOIETIC STEM CELL; HETEROZYGOUS FOR THE SFPI1-GFP REPORTER GENE; HOMOZYGOUS FOR THE SFPI1-GFP REPORTER GENE; HSC; IMDM; INTERSTITIAL DELETION OF CHROMOSOME 2; IONISING RADIATION; IR; ISCOVE'S MODIFIED DULBECCO'S MEDIUM; LIN(-); LIN(-) SCA-1(+) C-KIT(+); LINEAGE NEGATIVE IMMATURE BONE MARROW CELLS; LSK; MEP; MMP; MOUSE MODEL; MULTI-POTENT PROGENITOR; MYELOID LEUKAEMIA; MYELOID-ERYTHROID PROGENITOR; RADIATION; RADIATION-INDUCED ACUTE MYELOID LEUKAEMIA; RAML; SFPI1(GFP/+); SFPI1(GFP/GFP); SFPI1/PU.1; STEM CELLS;

ANIMALS; ANTIGENS, LY; BONE MARROW; CELL LINEAGE; CELLS, CULTURED; CHROMOSOME DELETION; CHROMOSOMES; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; IMMUNOMAGNETIC SEPARATION; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; PROTO-ONCOGENE PROTEINS C-KIT; X-RAYS;

ANIMALIA; MUS;

EID: 84884202803     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.04.018     Document Type: Article

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