Clinical significance of serum hepcidin-25 levels in predicting invasive fungal disease in patients after transplantation

European Review for Medical and Pharmacological Sciences

Volumn 17, Issue 13, 2013, Pages 1769-1773

  Chen, J ^a   Zhong, L ^a  

^a SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Hepcidin 25; Invasive fungal disease; Prognosis; Transplantation

Indexed keywords

BETA 1,3 GLUCAN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; FERRITIN; HEPCIDIN; HEPCIDIN 25; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BETA GLUCAN;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INCIDENCE; INFECTION; INFLAMMATION; INVASIVE FUNGAL DISEASE; IRON METABOLISM; IRON OVERLOAD; KIDNEY TRANSPLANTATION; LABORATORY TEST; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; OVERALL SURVIVAL; PATIENT MONITORING; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREDICTION; PREVALENCE; PROGNOSIS; SERUM; STEM CELL TRANSPLANTATION; TRANSPLANTATION; AGED; BLOOD; MIDDLE AGED; ORGAN TRANSPLANTATION; PREDICTIVE VALUE;

ADULT; AGED; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-GLUCANS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; HUMANS; MALE; MIDDLE AGED; MYCOSES; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; YOUNG ADULT;

EID: 84884194308     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. MAJHAIL NS, LAZARUS HM, BURNS LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Ttranspl 2008; 41: 997-1003.
2. ARMAND P, KIM HT, CUTLER CS, HO VT, KORETH J, ALYEA EP, SOIFFER RJ, ANTIN JH. Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood 2007; 109: 4586-4588.
3. ALTES A, REMACHA AF, SARDA P, BAIGET M, SUREDA A, MARTINO R, BRIONES J, BRUNET S, CANALS C, SIERRA J. Early clinical impact of iron overload in stem cell transplantation. A prospective study. Ann Hematol 2007; 86: 443-447.
4. PULLARKAT V, BLANCHARD S, TEGTMEIER B, DAGIS A, PATANE K, ITO J, FORMAN SJ. Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation. Bone Marrow Transpl 2008; 42: 799-805.
5. PLATZBECKER U, BORNHAUSER M, GERMING U, STUMPF J, SCOTT BL, KROGER N, SCHWERDTFEGER R, BOHM A, KOBBE G, THEUSER C, RABITSCH W, VALENT P, SORROR ML, EHNINGER G, DEEG HJ. Red blood cell transfusion dependence and outcome after allogeneic peripheral blood stem cell transplantation in patients with de novo myelodysplastic syndrome (MDS). Biology of blood and marrow transplantation. J Am Soc Blood Marrow Transpl 2008; 14: 1217-1225.
6. KATAOKA K, NANNYA Y, HANGAISHI A, IMAI Y, CHIBA S, TAKAHASHI T, KUROKAWA M. Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. Biology of blood and marrow transplantation. J Am Soc Blood Marrow Transpl 2009; 15: 195-204.
7. DE PAUW B, WALSH TJ, DONNELLY JP, STEVENS DA, EDWARDS JE, CALANDRA T, PAPPAS PG, MAERTENS J, LORTHOLARY O, KAUFFMAN CA, DENNING DW, PATTERSON TF, MASCHMEYER G, BILLE J, DISMUKES WE, HERBRECHT R, HOPE WW, KIBBLER CC, KULLBERG BJ, MARR KA, MUNOZ P, ODDS FC, PERFECT JR, RESTREPO A, RUHNKE M, SEGAL BH, SOBEL JD, SORRELL TC, VISCOLI C, WINGARD JR, ZAOUTIS T, BENNETT JE. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008; 46: 1813-1821.
8. PARK CH, VALORE EV, WARING AJ, GANZ T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
9. NEMETH E, TUTTLE MS, POWELSON J, VAUGHN MB, DONOVAN A, WARD DM, GANZ T, KAPLAN J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090-2093.
10. KEMNA EH, KARTIKASARI AE, VAN TITS LJ, PICKKERS P, TJALSMA H, SWINKELS DW. Regulation of hepcidin: insights from biochemical analyses on human serum samples. Blood Cell Mol Dis 2008; 40: 339-346.
11. KAO AS, BRANDT ME, PRUITT WR, CONN LA, PERKINS BA, STEPHENS DS, BAUGHMAN WS, REINGOLD AL, ROTHROCK GA, PFALLER MA, PINNER RW, HAJJEH RA. The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin Infect Dis 1999; 29: 1164-1170.
12. GANZ T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 2005; 18: 171-182.
13. NEMETH E, RIVERA S, GABAYAN V, KELLER C, TAUDORF S, PEDERSEN BK, GANZ T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113: 1271-1276.
14. LEE P, PENG H, GELBART T, WANG L, BEUTLER E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005; 102: 1906-1910.
15. KEMNA E, PICKKERS P, NEMETH E, VAN DER HOEVEN H, SWINKELS D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005; 106: 1864-1866.
16. NEMETH E, VALORE EV, TERRITO M, SCHILLER G, LICHTENSTEIN A, GANZ T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463.
17. PEYSSONNAUX C, ZINKERNAGEL AS, DATTA V, LAUTH X, JOHNSON RS, NIZET V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006; 107: 3727-3732.
18. MICELI MH, DONG L, GRAZZIUTTI ML, FASSAS A, THERTULIEN R, VAN RHEE F, BARLOGIE B, ANAISSIE EJ. Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: a study of 367 myeloma patients. Bone Marrow Transpl 2006; 37: 857-864.
19. KANDA J, MIZUMOTO C, KAWABATA H, ICHINOHE T, TSUCHIDA H, TOMOSUGI N, MATSUO K, YAMASHITA K, KONDO T, ISHIKAWA T, UCHIYAMA T. Clinical significance of serum hepcidin levels on early infectious complications in allogeneic hematopoietic stem cell transplantation. Biology of blood and marrow transplantation. J Am Soc Blood Marrow Transpl 2009; 15: 956-962.