Early clinical impact of iron overload in stem cell transplantation. A prospective study

Annals of Hematology

Volumn 86, Issue 6, 2007, Pages 443-447

  Altes, Albert ^a,b   Remacha, Angel Francisco ^a   Sarda, Pilar ^a   Baiget, Montserrat ^a   Sureda, Anna ^a   Martino, Rodrigo ^a   Briones, Javier ^a   Brunet, Salut ^a   Canals, Carme ^a   Sierra, Jorge ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL DE L ESPERIT SANT   (Spain)

Author keywords

Bacteraemia; Febrile days; Iron overload; Mucositis; Stem cell transplantation

Indexed keywords

CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FERRITIN; FLUDARABINE; MELPHALAN; TRANSFERRIN;

ADULT; AGED; ARTICLE; BACTEREMIA; CLINICAL TRIAL; DISEASE SEVERITY; DRUG MEGADOSE; FEMALE; FEVER; HUMAN; IRON METABOLISM; IRON OVERLOAD; LEUKEMIA; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; MYELODYSPLASTIC SYNDROME; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; STEM CELL TRANSPLANTATION; UNIVARIATE ANALYSIS;

ADULT; AGED; BACTEREMIA; FEMALE; FERRITINS; FEVER; HUMANS; INFECTION; IRON OVERLOAD; MALE; MIDDLE AGED; MUCOSITIS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROSPECTIVE STUDIES; TRANSFERRIN; TRANSPLANTATION CONDITIONING;

EID: 34247518331     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-007-0266-x     Document Type: Article

References (17)

1. Altes A, Remacha AF, Sureda A, Martino R, Briones J, Canals C, Brunet S, Sierra J, Gimferrer E (2002) Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. Bone Marrow Transplant 29:987-989
2. Altes A, Remacha AF, Sarda P, Sancho FJ, Sureda A, Martino R, Briones J, Brunet S, Canals C, Sierra J (2004) Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis. Bone Marrow Transplant 34:505-509
3. Altes A, Ruiz A, Barceló MJ, Remacha AF, Puig T, Maya AJ, Castell C, Amate JM, Saz Z, Baiget M (2004) Prevalence of the C282Y, H63D, and S65C mutations of the HFE gene in 1,146 newborns from a region of Northern Spain. Genet Test 8:407-410
4. Altes A, Remacha AF, Sarda P, Baiget M, Canals C, Sierra J (2006) The relationship between transferrin saturation and erythropoiesis during stem cell transplantation. Haematologica 91:992-993
5. Bullen JJ, Rogers HJ, Griffiths E (1978) Role of iron in bacterial infection. Curr Top Microbiol Immunol 80:1-35
6. Bullen JJ (1981) The significance of iron in infection. Rev Infect Dis 3:1127-1138
7. Carmine TC, Evans P, Bruchelt G, Evans R, Handgretinger R, Niethammer D, Halliwell B (1995) Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: Implications for therapeutic management. Cancer Lett 94:219-226
8. de la Serna J, Bornstein R, García-Bueno MJ, Lahuerta-Palacios JJ (1999) Iron depletion by phlebotomy with recombinant erythropoietin prior to allogeneic transplantation to prevent liver toxicity. Bone Marrow Transplant 23:95-97
9. Elin RJ, Wolff SM (1974) The role of iron in nonspecific resistance to infection induced by endotoxin. J Immunol 112:737-745
10. Griffiths E (1999) Iron in biological systems. In: Bullen JJ, Griffiths E (eds) Iron and infection. Molecular, physiological and clinical aspects. Wiley, Chichester, pp 1-26
11. Halliwell B, Gutteridge JM, Cross CE (1992) Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 119:598-620
12. Iglesias-Osma C, Gonzalez-Villaron L, San Miguel JF, Caballero MD, Vazquez L, de Castro S (1995) Iron metabolism and fungal infections in patients with haematological malignancies. J Clin Pathol 48:223-225
13. Maertens J, Demuynck H, Verbeken EK, Zachee P, Verhoef GE, Vandenberghe P, Boogaerts MA (1999) Mucormycosis in allogeneic bone marrow transplant recipients: Report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 24:307-312
14. Martino R, Caballero MD, Canals C, Simon JA, Solano C, Urbano-Ispizua A, Bargay J, Rayon C, Leon A, Sarra J, Odriozola J, Conde JG, Sierra J, San Miguel J; ALLOPBSCT Subcommittee of the Spanish Group for Haematopoietic Transplantation (GETH); Group GEL-TAMO (2001) Allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning: results of a prospective multicentre study. Br J Haematol 115:653-659
15. Miceli MH, Dong L, Grazziutti ML, Fassas A, Tertulien R, Van Rhee F, Barlogie B, Anaissie EJ (2006) Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: A study of 367 myeloma patients. Bone Marrow Transplant 37:857-864
16. Sahlstedt L, Ebeling F, Bonsdorff L, Parkkinen J, Ruutu T (2001) Non-transferrin-bound iron during allogeneic stem cell transplantation. Br J Haematol 113:836-838
17. Strasser SI, Kowdley KV, Sale GE, Mc Donald GB (1998) Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 22:167-173