Tiam1 Transgenic Mice Display Increased Tumor Invasive and Metastatic Potential of Colorectal Cancer after 1,2-Dimethylhydrazine Treatment

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Yu, Li Na ^a   Zhang, Qing Ling ^a   Li, Xin ^a   Hua, Xing ^b   Cui, Yan Mei ^a   Zhang, Nian Jie ^a   Liao, Wen Ting ^a   Ding, Yan Qing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU RED CROSS HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; T LYMPHOMA INVASION AND METASTASIS 1; TUMOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FLUORESCENCE IMAGING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; METASTASIS POTENTIAL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; TRANSGENIC MOUSE; TUMOR INVASION; UPREGULATION;

1,2-DIMETHYLHYDRAZINE; ANIMALS; COLORECTAL NEOPLASMS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WNT SIGNALING PATHWAY;

EID: 84884190223     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073077     Document Type: Article

References (28)

1. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, et al. (1994) Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77: 537-549.
2. Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, et al. (2002) RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem 277: 47810-47817.
3. Coleman ML, Marshall CJ, Olson MF, (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol 5: 355-366.
4. Minard ME, Ellis LM, Gallick GE, (2006) Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis 23: 301-313.
5. Qi Y, Huang B, Yu L, Wang Q, Lan G, et al. (2009) Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec 71: 163-171.
6. Engers R, Mueller M, Walter A, Collard JG, Willers R, et al. (2006) Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer 95: 1081-1086.
7. Adam L, Vadlamudi RK, McCrea P, Kumar R, (2001) Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem 276: 28443-28450.
8. Baraniskin A, Birkenkamp-Demtroder K, Maghnouj A, Zollner H, Munding J, et al. (2012) MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. Carcinogenesis 33: 732-739.
9. Bao Y, Lin C, Ren J, Liu J, (2013) MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3K p110delta). Apoptosis 18: 260-270.
10. Engers R, Springer E, Michiels F, Collard JG, Gabbert HE, (2001) Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression. J Biol Chem 276: 41889-41897.
11. Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC, et al. (1997) Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278: 1464-1466.
12. Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F, et al. (2002) Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417: 867-871.
13. Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, et al. (2010) The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene 29: 6533-6542.
14. Walch A, Seidl S, Hermannstadter C, Rauser S, Deplazes J, et al. (2008) Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol 21: 544-552.
15. Minard ME, Kim LS, Price JE, Gallick GE, (2004) The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat 84: 21-32.
16. Malliri A, van Es S, Huveneers S, Collard JG, (2004) The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J Biol Chem 279: 30092-30098.
17. Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG, (1999) Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol 147: 1009-1022.
18. Bourguignon LY, Zhu H, Shao L, Chen YW, (2000) CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem 275: 1829-1838.
19. Minard ME, Herynk MH, Collard JG, Gallick GE, (2005) The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model. Oncogene 24: 2568-2573.
20. Cruz-Monserrate Z, O'Connor KL, (2008) Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia 10: 408-417.
21. Michiels F, Habets GG, Stam JC, van der Kammen RA, Collard JG, (1995) A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375: 338-340.
22. van Leeuwen FN, van der Kammen RA, Habets GG, Collard JG, (1995) Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells. Oncogene 11: 2215-2221.
23. Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, et al. (2004) The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci 117: 4863-4871.
24. Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, et al. (2006) The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281: 543-548.
25. Bodemann BO, White MA, (2008) Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer 8: 133-140.
26. Esufali S, Bapat B, (2004) Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 23: 8260-8271.
27. Zhong M, Bian Z, Wu Z, (2013) miR-30a Suppresses Cell Migration and Invasion Through Downregulation of PIK3CD in Colorectal Carcinoma. Cell Physiol Biochem 31: 209-218.
28. Buongiorno P, Pethe VV, Charames GS, Esufali S, Bapat B, (2008) Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol Cancer 7: 73-88.