-
1
-
-
0345734260
-
Basement membrane proteins promote progression of intraepithelial neo-plasia in 3-dimensional models of human stratified epithelium
-
Andriani F, Garfield J, Fusenig NE, Garlick JA. (2004). Basement membrane proteins promote progression of intraepithelial neo-plasia in 3-dimensional models of human stratified epithelium. Int J Cancer 108: 348-357.
-
(2004)
Int J Cancer
, vol.108
, pp. 348-357
-
-
Andriani, F.1
Garfield, J.2
Fusenig, N.E.3
Garlick, J.A.4
-
2
-
-
33744516825
-
Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth
-
Baines AT, Lim KH, Shields JM, Lambert JM, Counter CM, Der CJ et al. (2006). Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. Methods Enzymol 407: 556-574.
-
(2006)
Methods Enzymol
, vol.407
, pp. 556-574
-
-
Baines, A.T.1
Lim, K.H.2
Shields, J.M.3
Lambert, J.M.4
Counter, C.M.5
Der, C.J.6
-
3
-
-
0842288323
-
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S et al. (2004a). TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303: 848-851.
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
-
5
-
-
9244227134
-
Stromal fibroblasts in cancer initiation and progression
-
Bhowmick NA, Neilson EG, Moses HL. (2004b). Stromal fibroblasts in cancer initiation and progression. Nature 432: 332-337.
-
(2004)
Nature
, vol.432
, pp. 332-337
-
-
Bhowmick, N.A.1
Neilson, E.G.2
Moses, H.L.3
-
6
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski MS, McCormick F. (1993). Proteins regulating Ras and its relatives. Nature 366: 643-654.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
7
-
-
0025275853
-
C-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy
-
Boukamp P, Stanbridge EJ, Foo DY, Cerutti PA, Fusenig NE. (1990). c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res 50: 2840-2847.
-
(1990)
Cancer Res
, vol.50
, pp. 2840-2847
-
-
Boukamp, P.1
Stanbridge, E.J.2
Foo, D.Y.3
Cerutti, P.A.4
Fusenig, N.E.5
-
8
-
-
34248210086
-
Rho activation at a glance
-
Buchsbaum RJ. (2007). Rho activation at a glance. J Cell Sci 120: 1149-1152.
-
(2007)
J Cell Sci
, vol.120
, pp. 1149-1152
-
-
Buchsbaum, R.J.1
-
9
-
-
18944389626
-
Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoske-leton regulation
-
Connolly BA, Rice J, Feig LA, Buchsbaum RJ. (2005). Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoske-leton regulation. Mol Cell Biol 25: 4602-4614.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4602-4614
-
-
Connolly, B.A.1
Rice, J.2
Feig, L.A.3
Buchsbaum, R.J.4
-
10
-
-
43249118924
-
Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation
-
Cruz-Monserrate Z, O'Connor KL. (2008). Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia 10: 408-417.
-
(2008)
Neoplasia
, vol.10
, pp. 408-417
-
-
Cruz-Monserrate, Z.1
O'Connor, K.L.2
-
11
-
-
0024841473
-
Mesenchymal-epithelial interactions in the growth and development of the prostate
-
Cunha GR, Donjacour AA. (1989). Mesenchymal-epithelial interactions in the growth and development of the prostate. Cancer Treat Res 46: 159-175.
-
(1989)
Cancer Treat Res
, vol.46
, pp. 159-175
-
-
Cunha, G.R.1
Donjacour, A.A.2
-
12
-
-
0242266916
-
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
-
Debnath J, Walker SJ, Brugge JS. (2003). Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol 163: 315-326.
-
(2003)
J Cell Biol
, vol.163
, pp. 315-326
-
-
Debnath, J.1
Walker, S.J.2
Brugge, J.S.3
-
13
-
-
0942279704
-
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes
-
Erickson JW, Cerione RA. (2004). Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry 43: 837-842.
-
(2004)
Biochemistry
, vol.43
, pp. 837-842
-
-
Erickson, J.W.1
Cerione, R.A.2
-
14
-
-
0031728635
-
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes
-
Fusenig NE, Boukamp P. (1998). Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol Carcinogen 23: 144-158.
-
(1998)
Mol Carcinogen
, vol.23
, pp. 144-158
-
-
Fusenig, N.E.1
Boukamp, P.2
-
15
-
-
33750296449
-
Engineering skin to study human disease-tissue models for cancer biology and wound repair
-
Garlick JA. (2007). Engineering skin to study human disease-tissue models for cancer biology and wound repair. Adv Biochem Eng Biotechnol 103: 207-239.
-
(2007)
Adv Biochem Eng Biotechnol
, vol.103
, pp. 207-239
-
-
Garlick, J.A.1
-
16
-
-
33751252276
-
Cancer metastasis: Building a framework
-
Gupta GP, Massague J. (2006). Cancer metastasis: building a framework. Cell 127: 679-695.
-
(2006)
Cell
, vol.127
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
17
-
-
0028225439
-
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
-
Habets GG, Scholtes EH, Zuydgeest D, Van der Kammen RA, Stam JC, Berns A et al. (1994). Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77: 537-549.
-
(1994)
Cell
, vol.77
, pp. 537-549
-
-
Habets, G.G.1
Scholtes, E.H.2
Zuydgeest, D.3
Van Der Kammen, R.A.4
Stam, J.C.5
Berns, A.6
-
18
-
-
0032559362
-
Rho GTPases and the actin cytoskeleton
-
Hall A. (1998). Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
19
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
21
-
-
0026565374
-
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells
-
Jue SF, Bradley RS, Rudnicki JA, Varmus HE, Brown AM. (1992). The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 12: 321-328.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 321-328
-
-
Jue, S.F.1
Bradley, R.S.2
Rudnicki, J.A.3
Varmus, H.E.4
Brown, A.M.5
-
22
-
-
23844460881
-
Three-dimensional tissue culture models in cancer biology
-
Kim JB. (2005). Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol 15: 365-377.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 365-377
-
-
Kim, J.B.1
-
23
-
-
1842687362
-
Reconstruction of functionally normal and malignant human breast tissues in mice
-
Kuperwasser C, Chavarria T, Wu M, Magrane G, Gray JW, Carey L et al. (2004). Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA 101: 4966-4971.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4966-4971
-
-
Kuperwasser, C.1
Chavarria, T.2
Wu, M.3
Magrane, G.4
Gray, J.W.5
Carey, L.6
-
24
-
-
22244455403
-
A mouse model of human breast cancer metastasis to human bone
-
Kuperwasser C, Dessain S, Bierbaum BE, Garnet D, Sperandio K, Gauvin GP et al. (2005). A mouse model of human breast cancer metastasis to human bone. Cancer Res 65: 6130-6138.
-
(2005)
Cancer Res
, vol.65
, pp. 6130-6138
-
-
Kuperwasser, C.1
Dessain, S.2
Bierbaum, B.E.3
Garnet, D.4
Sperandio, K.5
Gauvin, G.P.6
-
25
-
-
0036843937
-
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
-
Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. (2002). Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 32: 355-357.
-
(2002)
Nat Genet
, vol.32
, pp. 355-357
-
-
Kurose, K.1
Gilley, K.2
Matsumoto, S.3
Watson, P.H.4
Zhou, X.P.5
Eng, C.6
-
26
-
-
34447276000
-
Tumor microenvironment: The role of the tumor stroma in cancer
-
Li H, Fan X, Houghton J. (2007). Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem 101: 805-815.
-
(2007)
J Cell Biochem
, vol.101
, pp. 805-815
-
-
Li, H.1
Fan, X.2
Houghton, J.3
-
27
-
-
13544262611
-
Tiam1 gene expression and its significance in colorectal carcinoma
-
Liu L, Wu DH, Ding YQ. (2005). Tiam1 gene expression and its significance in colorectal carcinoma. World J Gastroenterol 11: 705-707.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 705-707
-
-
Liu, L.1
Wu, D.H.2
Ding, Y.Q.3
-
28
-
-
33750726727
-
Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line
-
Liu L, Zhang Q, Zhang Y, Wang S, Ding Y. (2006). Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line. Neoplasia 8: 917-924.
-
(2006)
Neoplasia
, vol.8
, pp. 917-924
-
-
Liu, L.1
Zhang, Q.2
Zhang, Y.3
Wang, S.4
Ding, Y.5
-
29
-
-
33644859051
-
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development
-
Malliri A, Rygiel TP, Van der Kammen RA, Song JY, Engers R, Hurlstone AF et al. (2006). The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281: 543-548.
-
(2006)
J Biol Chem
, vol.281
, pp. 543-548
-
-
Malliri, A.1
Rygiel, T.P.2
Van Der Kammen, R.A.3
Song, J.Y.4
Engers, R.5
Hurlstone, A.F.6
-
30
-
-
0037142034
-
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
-
Malliri A, Van der Kammen RA, Clark K, Van der Valk M, Michiels F, Collard JG. (2002). Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417: 867-871.
-
(2002)
Nature
, vol.417
, pp. 867-871
-
-
Malliri, A.1
Van Der Kammen, R.A.2
Clark, K.3
Van Der Valk, M.4
Michiels, F.5
Collard, J.G.6
-
31
-
-
16444368642
-
E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs
-
Margulis A, Zhang W, Alt-Holland A, Crawford HC, Fusenig NE, Garlick JA. (2005). E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res 65: 1783-1791.
-
(2005)
Cancer Res
, vol.65
, pp. 1783-1791
-
-
Margulis, A.1
Zhang, W.2
Alt-Holland, A.3
Crawford, H.C.4
Fusenig, N.E.5
Garlick, J.A.6
-
33
-
-
17844400108
-
The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model
-
Minard ME, Herynk MH, Collard JG, Gallick GE. (2005). The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model. Oncogene 24: 2568-2573.
-
(2005)
Oncogene
, vol.24
, pp. 2568-2573
-
-
Minard, M.E.1
Herynk, M.H.2
Collard, J.G.3
Gallick, G.E.4
-
34
-
-
1642343506
-
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression
-
Minard ME, Kim LS, Price JE, Gallick GE. (2004). The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat 84: 21-32.
-
(2004)
Breast Cancer Res Treat
, vol.84
, pp. 21-32
-
-
Minard, M.E.1
Kim, L.S.2
Price, J.E.3
Gallick, G.E.4
-
35
-
-
0342264492
-
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
-
Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M, Tavassoli FA. (2000). Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res 60: 2562-2566.
-
(2000)
Cancer Res
, vol.60
, pp. 2562-2566
-
-
Moinfar, F.1
Man, Y.G.2
Arnould, L.3
Bratthauer, G.L.4
Ratschek, M.5
Tavassoli, F.A.6
-
36
-
-
37349101054
-
Breast-cancer stromal cells with TP53 mutations and nodal metastases
-
Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL et al. (2007). Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 357: 2543-2551.
-
(2007)
N Engl J Med
, vol.357
, pp. 2543-2551
-
-
Patocs, A.1
Zhang, L.2
Xu, Y.3
Weber, F.4
Caldes, T.5
Mutter, G.L.6
-
37
-
-
77952894836
-
Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1)
-
Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J et al. (2010). Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biological Chemistry 285: 18060-18071.
-
(2010)
J Biological Chemistry
, vol.285
, pp. 18060-18071
-
-
Rajagopal, S.1
Ji, Y.2
Xu, K.3
Li, Y.4
Wicks, K.5
Liu, J.6
-
38
-
-
13444252631
-
GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
-
Rossman KL, Der CJ, Sondek J. (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 167-180
-
-
Rossman, K.L.1
Der, C.J.2
Sondek, J.3
-
39
-
-
44449162944
-
The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation
-
Rygiel TP, Mertens AE, Strumane K, Van der Kammen R, Collard JG. (2008). The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 121: 1183-1192.
-
(2008)
J Cell Sci
, vol.121
, pp. 1183-1192
-
-
Rygiel, T.P.1
Mertens, A.E.2
Strumane, K.3
Van Der Kammen, R.4
Collard, J.G.5
-
40
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
-
Schmidt A, Hall A. (2002). Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16: 1587-1609.
-
(2002)
Genes Dev
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
41
-
-
40649095216
-
The basement membrane microenvironment directs the normalization and survival of bioengineered human skin equivalents
-
Segal N, Andriani F, Pfeiffer L, Kamath P, Lin N, Satyamurthy K et al. (2008). The basement membrane microenvironment directs the normalization and survival of bioengineered human skin equivalents. Matrix Biol 27: 163-170.
-
(2008)
Matrix Biol
, vol.27
, pp. 163-170
-
-
Segal, N.1
Andriani, F.2
Pfeiffer, L.3
Kamath, P.4
Lin, N.5
Satyamurthy, K.6
-
42
-
-
36049049416
-
Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency
-
Strumane K, Song JY, Baas I, Collard JG. (2008). Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency. Leuk Res 32: 113-120.
-
(2008)
Leuk Res
, vol.32
, pp. 113-120
-
-
Strumane, K.1
Song, J.Y.2
Baas, I.3
Collard, J.G.4
-
43
-
-
0642375769
-
Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line
-
Supriatno, Harada K, Kawaguchi S, Yoshida H, Sato M. (2003). Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line. Oncol Rep 10: 527-532.
-
(2003)
Oncol Rep
, vol.10
, pp. 527-532
-
-
Supriatno Harada, K.1
Kawaguchi, S.2
Yoshida, H.3
Sato, M.4
-
44
-
-
34447272058
-
Mechanisms of metastasis: Epithelial-to-mesenchymal transition and contribution of tumor microenviron-ment
-
Tse JC, Kalluri R. (2007). Mechanisms of metastasis: epithelial-to- mesenchymal transition and contribution of tumor microenviron-ment. J Cell Biochem 101: 816-829.
-
(2007)
J Cell Biochem
, vol.101
, pp. 816-829
-
-
Tse, J.C.1
Kalluri, R.2
-
45
-
-
34047185902
-
Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation
-
Willhauck MJ, Mirancea N, Vosseler S, Pavesio A, Boukamp P, Mueller MM et al. (2007). Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation. Carcinogenesis 28: 595-610.
-
(2007)
Carcinogenesis
, vol.28
, pp. 595-610
-
-
Willhauck, M.J.1
Mirancea, N.2
Vosseler, S.3
Pavesio, A.4
Boukamp, P.5
Mueller, M.M.6
-
46
-
-
34547931078
-
Modeling tissue morphogenesis and cancer in 3D
-
Yamada KM, Cukierman E. (2007). Modeling tissue morphogenesis and cancer in 3D. Cell 130: 601-610.
-
(2007)
Cell
, vol.130
, pp. 601-610
-
-
Yamada, K.M.1
Cukierman, E.2
|