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Volumn 249, Issue , 2013, Pages 59-73

Dorsal column sensory axons degenerate due to impaired microvascular perfusion after spinal cord injury in rats

Author keywords

Axonal degeneration; Blood flow; Capillaries; Contusion; Ischemia; Oligodendrocytes; Spinal cord injury

Indexed keywords

ETHIDIUM BROMIDE;

EID: 84884166394     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.08.009     Document Type: Article
Times cited : (24)

References (55)
  • 3
    • 0028794076 scopus 로고
    • Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury
    • Anthes D.L., Theriault E., Tator C.H. Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury. Brain Res. 1995, 702:1-16.
    • (1995) Brain Res. , vol.702 , pp. 1-16
    • Anthes, D.L.1    Theriault, E.2    Tator, C.H.3
  • 4
    • 17844400031 scopus 로고    scopus 로고
    • An adult rat spinal cord contusion model of sensory axon degeneration: the estrus cycle or a preconditioning lesion do not affect outcome
    • Baker K.A., Hagg T. An adult rat spinal cord contusion model of sensory axon degeneration: the estrus cycle or a preconditioning lesion do not affect outcome. J. Neurotrauma 2005, 22:415-428.
    • (2005) J. Neurotrauma , vol.22 , pp. 415-428
    • Baker, K.A.1    Hagg, T.2
  • 5
    • 34247239386 scopus 로고    scopus 로고
    • Dorsal column sensory axons lack TrkC and are not rescued by local neurotrophin-3 infusions following spinal cord contusion in adult rats
    • Baker K.A., Nakashima S., Hagg T. Dorsal column sensory axons lack TrkC and are not rescued by local neurotrophin-3 infusions following spinal cord contusion in adult rats. Exp. Neurol. 2007, 205:82-91.
    • (2007) Exp. Neurol. , vol.205 , pp. 82-91
    • Baker, K.A.1    Nakashima, S.2    Hagg, T.3
  • 6
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso D.M., Beattie M.S., Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 1996, 139:244-256.
    • (1996) Exp. Neurol. , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 7
    • 83355162673 scopus 로고    scopus 로고
    • Vascular pathology as a potential therapeutic target in SCI
    • Benton R.L., Hagg T. Vascular pathology as a potential therapeutic target in SCI. Transl. Stroke Res. 2011, 2:556-574.
    • (2011) Transl. Stroke Res. , vol.2 , pp. 556-574
    • Benton, R.L.1    Hagg, T.2
  • 8
    • 38949158421 scopus 로고    scopus 로고
    • Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse
    • Benton R.L., Maddie M.A., Minnillo D.R., Hagg T., Whittemore S.R. Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse. J. Comp. Neurol. 2008, 507:1031-1052.
    • (2008) J. Comp. Neurol. , vol.507 , pp. 1031-1052
    • Benton, R.L.1    Maddie, M.A.2    Minnillo, D.R.3    Hagg, T.4    Whittemore, S.R.5
  • 9
    • 77953421054 scopus 로고    scopus 로고
    • Transcriptional activation of endothelial cells by TGFβ coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury
    • Benton R.L., Maddie M.A., Dincman T.A., Hagg T., Whittemore S.R. Transcriptional activation of endothelial cells by TGFβ coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. ASN Neuro 2009, 1:e00015.
    • (2009) ASN Neuro , vol.1
    • Benton, R.L.1    Maddie, M.A.2    Dincman, T.A.3    Hagg, T.4    Whittemore, S.R.5
  • 10
    • 0020422723 scopus 로고
    • Ethidium bromide induced demyelination in the spinal cord of the cat
    • Blakemore W.F. Ethidium bromide induced demyelination in the spinal cord of the cat. Neuropathol. Appl. Neurobiol. 1982, 8:365-375.
    • (1982) Neuropathol. Appl. Neurobiol. , vol.8 , pp. 365-375
    • Blakemore, W.F.1
  • 11
    • 0028306456 scopus 로고
    • Characterization of photochemically induced spinal cord injury in the rat by light and electron microscopy
    • Bunge M.B., Holets V.R., Bates M.L., Clarke T.S., Watson B.D. Characterization of photochemically induced spinal cord injury in the rat by light and electron microscopy. Exp. Neurol. 1994, 127:76-93.
    • (1994) Exp. Neurol. , vol.127 , pp. 76-93
    • Bunge, M.B.1    Holets, V.R.2    Bates, M.L.3    Clarke, T.S.4    Watson, B.D.5
  • 14
    • 38749086493 scopus 로고    scopus 로고
    • Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
    • Donnelly D.J., Popovich P.G. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp. Neurol. 2008, 209:378-388.
    • (2008) Exp. Neurol. , vol.209 , pp. 378-388
    • Donnelly, D.J.1    Popovich, P.G.2
  • 16
    • 79955063410 scopus 로고    scopus 로고
    • Targeting microvasculature for neuroprotection after SCI
    • Fassbender J.M., Whittemore S.R., Hagg T. Targeting microvasculature for neuroprotection after SCI. Neurotherapeutics 2011, 8:240-251.
    • (2011) Neurotherapeutics , vol.8 , pp. 240-251
    • Fassbender, J.M.1    Whittemore, S.R.2    Hagg, T.3
  • 17
    • 0029012783 scopus 로고
    • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
    • Fehlings M.G., Tator C.H. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp. Neurol. 1995, 132:220-228.
    • (1995) Exp. Neurol. , vol.132 , pp. 220-228
    • Fehlings, M.G.1    Tator, C.H.2
  • 18
    • 0034084290 scopus 로고    scopus 로고
    • Reactions of oligodendrocytes to spinal cord injury: cell survival and myelin repair
    • Frei E., Klusman I., Schnell L., Schwab M.E. Reactions of oligodendrocytes to spinal cord injury: cell survival and myelin repair. Exp. Neurol. 2000, 163:373-380.
    • (2000) Exp. Neurol. , vol.163 , pp. 373-380
    • Frei, E.1    Klusman, I.2    Schnell, L.3    Schwab, M.E.4
  • 19
    • 0015176887 scopus 로고
    • Microangiographic observations of the experimentally traumatized spinal cord
    • Fried L.C., Goodkin R. Microangiographic observations of the experimentally traumatized spinal cord. J. Neurosurg. 1971, 35:709-714.
    • (1971) J. Neurosurg. , vol.35 , pp. 709-714
    • Fried, L.C.1    Goodkin, R.2
  • 21
    • 0024436784 scopus 로고
    • Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor
    • Guha A., Tator C.H., Smith C.R., Piper I. Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor. J. Trauma 1989, 29:1440-1447.
    • (1989) J. Trauma , vol.29 , pp. 1440-1447
    • Guha, A.1    Tator, C.H.2    Smith, C.R.3    Piper, I.4
  • 23
    • 77955983715 scopus 로고    scopus 로고
    • Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion
    • Itoh Y., Toriumi H., Yamada S., Hoshino H., Suzuki N. Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1725-1732.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1725-1732
    • Itoh, Y.1    Toriumi, H.2    Yamada, S.3    Hoshino, H.4    Suzuki, N.5
  • 24
    • 83455199070 scopus 로고    scopus 로고
    • Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages
    • James N.D., Bartus K., Grist J., Bennett D.L.H., McMahon S.B., Bradbury E.J. Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages. J. Neurosci. 2011, 31:18543-18555.
    • (2011) J. Neurosci. , vol.31 , pp. 18543-18555
    • James, N.D.1    Bartus, K.2    Grist, J.3    Bennett, D.L.H.4    McMahon, S.B.5    Bradbury, E.J.6
  • 26
    • 0027530177 scopus 로고
    • Silicone rubber microangiography of acute spinal cord injury in the rat
    • Koyanagi I., Tator C.H., Theriault E. Silicone rubber microangiography of acute spinal cord injury in the rat. Neurosurgery 1993, 32:260-268.
    • (1993) Neurosurgery , vol.32 , pp. 260-268
    • Koyanagi, I.1    Tator, C.H.2    Theriault, E.3
  • 28
    • 0029132999 scopus 로고
    • Changes of beta-amyloid precursor protein after compression trauma to the spinal cord: an experimental study in the rat using immunohistochemistry
    • Li G.L., Farooque M., Holtz A., Olsson Y. Changes of beta-amyloid precursor protein after compression trauma to the spinal cord: an experimental study in the rat using immunohistochemistry. J. Neurotrauma 1995, 12:269-277.
    • (1995) J. Neurotrauma , vol.12 , pp. 269-277
    • Li, G.L.1    Farooque, M.2    Holtz, A.3    Olsson, Y.4
  • 29
    • 33644920948 scopus 로고    scopus 로고
    • Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices
    • Li Y., Oskouian R.J., Day Y.-J., Kern J.A., Linden J. Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices. J. Neurosurg. Spine 2006, 4:165-173.
    • (2006) J. Neurosurg. Spine , vol.4 , pp. 165-173
    • Li, Y.1    Oskouian, R.J.2    Day, Y.-J.3    Kern, J.A.4    Linden, J.5
  • 30
    • 48249118712 scopus 로고    scopus 로고
    • Finite element analysis of spinal cord injury in the rat
    • Maikos J.T., Qian Z., Metaxas D., Shreiber D.I. Finite element analysis of spinal cord injury in the rat. J. Neurotrauma 2008, 25:795-816.
    • (2008) J. Neurotrauma , vol.25 , pp. 795-816
    • Maikos, J.T.1    Qian, Z.2    Metaxas, D.3    Shreiber, D.I.4
  • 33
    • 34347254639 scopus 로고    scopus 로고
    • In vivo imaging of single axons in the mouse spinal cord
    • Misgeld T., Nikic I., Kerschensteiner M. In vivo imaging of single axons in the mouse spinal cord. Nat. Protoc. 2007, 2:263-268.
    • (2007) Nat. Protoc. , vol.2 , pp. 263-268
    • Misgeld, T.1    Nikic, I.2    Kerschensteiner, M.3
  • 34
    • 84878268968 scopus 로고    scopus 로고
    • Intravenous infusion of magnesium chloride improves epicenter blood flow during the acute stage of contusive spinal cord injury in rats
    • Muradov J.M., Hagg T. Intravenous infusion of magnesium chloride improves epicenter blood flow during the acute stage of contusive spinal cord injury in rats. J. Neurotrauma 2013, 30:840-852.
    • (2013) J. Neurotrauma , vol.30 , pp. 840-852
    • Muradov, J.M.1    Hagg, T.2
  • 36
    • 49049114995 scopus 로고    scopus 로고
    • Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats
    • Nakashima S., Arnold S.A., Mahoney E.T., Sithu S.D., Zhang Y.P., D&apos, Souza S.E., Shields C.B., Hagg T. Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. J. Neurosci. 2008, 28:7293-7303.
    • (2008) J. Neurosci. , vol.28 , pp. 7293-7303
    • Nakashima, S.1    Arnold, S.A.2    Mahoney, E.T.3    Sithu, S.D.4    Zhang, Y.P.5    Souza, S.E.6    Shields, C.B.7    Hagg, T.8
  • 37
    • 43249098296 scopus 로고    scopus 로고
    • Axon-glial signaling and the glial support of axon function
    • Nave K.-A., Trapp B.D. Axon-glial signaling and the glial support of axon function. Annu. Rev. Neurosci. 2008, 31:535-561.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 535-561
    • Nave, K.-A.1    Trapp, B.D.2
  • 38
    • 0029782403 scopus 로고    scopus 로고
    • Primary demyelination and regeneration of ascending axons in the dorsal funiculus of the rat spinal cord following photochemically induced injury
    • Olby N.J., Blakemore W.F. Primary demyelination and regeneration of ascending axons in the dorsal funiculus of the rat spinal cord following photochemically induced injury. J. Neurocytol. 1996, 25:465-480.
    • (1996) J. Neurocytol. , vol.25 , pp. 465-480
    • Olby, N.J.1    Blakemore, W.F.2
  • 39
    • 0015321825 scopus 로고
    • Altered norepinephrine metabolism following experimental spinal cord injury. 1. Relationship to hemorrhagic necrosis and post-wounding neurological deficits
    • Osterholm J.L., Mathews G.J. Altered norepinephrine metabolism following experimental spinal cord injury. 1. Relationship to hemorrhagic necrosis and post-wounding neurological deficits. J. Neurosurg. 1972, 36:386-394.
    • (1972) J. Neurosurg. , vol.36 , pp. 386-394
    • Osterholm, J.L.1    Mathews, G.J.2
  • 40
    • 0028236660 scopus 로고
    • Regrowth of axons in lesioned adult rat spinal cord: promotion by implants of cultured Schwann cells
    • Paíno C.L., Fernandez-Valle C., Bates M.L., Bunge M.B. Regrowth of axons in lesioned adult rat spinal cord: promotion by implants of cultured Schwann cells. J. Neurocytol. 1994, 23:433-452.
    • (1994) J. Neurocytol. , vol.23 , pp. 433-452
    • Paíno, C.L.1    Fernandez-Valle, C.2    Bates, M.L.3    Bunge, M.B.4
  • 41
    • 0035008642 scopus 로고    scopus 로고
    • Cyclosporin A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing
    • Rabchevsky A.G., Fugaccia I., Sullivan P.G., Scheff S.W. Cyclosporin A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing. J. Neurotrauma 2001, 18:513-522.
    • (2001) J. Neurotrauma , vol.18 , pp. 513-522
    • Rabchevsky, A.G.1    Fugaccia, I.2    Sullivan, P.G.3    Scheff, S.W.4
  • 43
    • 0018070057 scopus 로고
    • Regional spinal cord blood flow in rats after severe cord trauma
    • Rivlin A.S., Tator C.H. Regional spinal cord blood flow in rats after severe cord trauma. J. Neurosurg. 1978, 49:844-853.
    • (1978) J. Neurosurg. , vol.49 , pp. 844-853
    • Rivlin, A.S.1    Tator, C.H.2
  • 44
    • 11144298992 scopus 로고    scopus 로고
    • Chronic alterations in the cellular composition of spinal cord white matter following contusion injury
    • Rosenberg L.J., Zai L.J., Wrathall J.R. Chronic alterations in the cellular composition of spinal cord white matter following contusion injury. Glia 2005, 49:107-120.
    • (2005) Glia , vol.49 , pp. 107-120
    • Rosenberg, L.J.1    Zai, L.J.2    Wrathall, J.R.3
  • 45
    • 0036311466 scopus 로고    scopus 로고
    • Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord
    • Schucht P., Raineteau O., Schwab M.E., Fouad K. Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp. Neurol. 2002, 176:143-153.
    • (2002) Exp. Neurol. , vol.176 , pp. 143-153
    • Schucht, P.1    Raineteau, O.2    Schwab, M.E.3    Fouad, K.4
  • 46
    • 1442279215 scopus 로고    scopus 로고
    • Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord
    • Sharma H.S. Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord. Acta Neurochir. Suppl. 2003, 86:383-388.
    • (2003) Acta Neurochir. Suppl. , vol.86 , pp. 383-388
    • Sharma, H.S.1
  • 47
    • 43449101472 scopus 로고    scopus 로고
    • Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat
    • Shields L.B.E., Zhang Y.P., Burke D.A., Gray R., Shields C.B. Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat. Surg. Neurol. 2008, 69:568-577.
    • (2008) Surg. Neurol. , vol.69 , pp. 568-577
    • Shields, L.B.E.1    Zhang, Y.P.2    Burke, D.A.3    Gray, R.4    Shields, C.B.5
  • 48
    • 84873292810 scopus 로고    scopus 로고
    • Myelin loss does not lead to axonal degeneration in a long-lived model of chronic demyelination
    • Smith C.M., Cooksey E., Duncan I.D. Myelin loss does not lead to axonal degeneration in a long-lived model of chronic demyelination. J Neurosci. 2013, 33:2718-2727.
    • (2013) J Neurosci. , vol.33 , pp. 2718-2727
    • Smith, C.M.1    Cooksey, E.2    Duncan, I.D.3
  • 50
    • 0031985806 scopus 로고    scopus 로고
    • Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics
    • Stys P.K. Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics. J. Cereb. Blood Flow Metab. 1998, 18:2-25.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 2-25
    • Stys, P.K.1
  • 51
    • 0141624363 scopus 로고    scopus 로고
    • White matter injury mechanisms
    • Stys P.K. White matter injury mechanisms. Curr. Mol. Med. 2004, 4:113-130.
    • (2004) Curr. Mol. Med. , vol.4 , pp. 113-130
    • Stys, P.K.1
  • 52
    • 0031017950 scopus 로고    scopus 로고
    • Vascular mechanisms in the pathophysiology of human spinal cord injury
    • Tator C.H., Koyanagi I. Vascular mechanisms in the pathophysiology of human spinal cord injury. J. Neurosurg. 1997, 86:483-492.
    • (1997) J. Neurosurg. , vol.86 , pp. 483-492
    • Tator, C.H.1    Koyanagi, I.2
  • 53
    • 0030773128 scopus 로고    scopus 로고
    • Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia
    • von Euler M., Sundström E., Seiger A. Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia. Acta Neuropathol. 1997, 94:232-239.
    • (1997) Acta Neuropathol. , vol.94 , pp. 232-239
    • von Euler, M.1    Sundström, E.2    Seiger, A.3
  • 54
    • 0043235662 scopus 로고    scopus 로고
    • Unilateral dorsal column and rubrospinal tract injuries affect overground locomotion in the unrestrained rat
    • Webb A.A., Muir G.D. Unilateral dorsal column and rubrospinal tract injuries affect overground locomotion in the unrestrained rat. Eur. J. Neurosci. 2003, 18:412-422.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 412-422
    • Webb, A.A.1    Muir, G.D.2
  • 55
    • 0141705210 scopus 로고    scopus 로고
    • Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing
    • Whetstone W.D., Hsu J.Y., Eisenberg M., Werb Z., Noble-Haeusslein L.J. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J. Neurosci. Res. 2003, 74:227-239.
    • (2003) J. Neurosci. Res. , vol.74 , pp. 227-239
    • Whetstone, W.D.1    Hsu, J.Y.2    Eisenberg, M.3    Werb, Z.4    Noble-Haeusslein, L.J.5


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