Bioassays for Screening and Functional Elucidation of Herbal Medicines

Traditional Herbal Medicine Research Methods: Identification, Analysis, Bioassay, and Pharmaceutical and Clinical Studies

Volumn , Issue , 2010, Pages 225-269

  Liu, Willow J H ^a  

^a 21st Century Herbs and Health Inc   (United States)

Author keywords

Bioassays, screening and herbal medicine functional elucidation and bioactive compound screening, new drugs in pharmaceutical companies; Enzyme assays, determining test extract interference compound to enzymatic activity, inhibitory ability of sample to enzyme activity; Gene expression assays, by cells dynamic responses, clues to regulatory mechanisms, biochemical pathways and cellular function

Indexed keywords

EID: 84884164152     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470921340.ch5     Document Type: Chapter

References (29)

1. Liu, J.H., et al. (2001) Evaluation of estrogenic activities of plant extracts on the potential treatment of menopausal sympotoms. Journal of Agricultural and Food Chemistry 49 (5): 2472-2479.
2. Burdette, J.E., et al. (2003) Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. Journal of Agricultural and Food Chemistry 51 (19): 5661-5670.
3. Newman, D.J., et al. (2003) Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products 66 (7): 1022-1037.
4. Rouhi, A.M. (2003) Rediscovering Natural Products. Chemical & Engineering News 81 (41): 77-78, 82-83, 86, 88-91.
5. Li, J.W. and Vederas, J.C. (2009) Drug discovery and natural products: end of an era or an endless frontier? Science 325 (5937): 161-165.
6. Koehn, F.E. (2008) High impact technologies for natural products screening. Progress in Drug Research 65 (175): 177-210.
7. Harvey, A.L. (2008) Natural products in drug discovery. Drug Discovery Today 13 (19-20): 894-901.
8. Mishra, K.P., et al. (2008) A review of high throughput technology for the screening of natural products. Biomedicine & Pharmacotherapy 62 (2): 94-98.
9. Powell, S.L., et al. (2008) In vitro serotonergic activity of black cohosh and identification of N ?-methylserotonin as a potential active constituent. Journal of Agricultural and Food Chemistry (24): 1718-1726.
10. Roxas, M.N.D. and Jurenka, J.M.T. (2007) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Alternative Medicine Review 12 (1): 25-48.
11. Collins, A., et al. (1997) A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of Chinese medicinal herbs. Life Sciences 60 (23): 345-351.
12. Liu, J.H., et al. (1998) Comparison of duhuo with its substitutes in terms of constituents and inhibitory effect on 5-LO and COX. Phramaceutical Biology 36 (3): 207-216.
13. Liu, J.H., et al. (2004) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste berry). Phytochemistry 11 (1): 18-23.
14. Segel, I.H. (1993) Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems. Hoboken, NJ, Wiley.
15. Cleland, W.W. (1963) The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory. Biochimica et Biophysica Acta 67: 173-187.
16. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1-2): 55-63.
17. Passonneau, J.V. and Lowry, O.H. (1993) Enzymatic Analysis, A Practical Guide. Totowa, NJ, Humana Press.
18. Todd, M.J. and Gomez, J. (2001) Enzyme kinetics determined using calorimetry: a general assay for enzyme activity? Analytical Biochemistry 296 (2): 179-187.
19. Stanley, P.E. and Kricka, L.J. (2002) Bioluminescence & Chemiluminescence: Progress & Current Application. Singapore, World Scientific Publishing.
20. Greer, L.F. and Szalay, A.A. (2002) Imaging of light emission from the expression of luciferases in living cells and organisms: a review. Luminescence 17 (1): 43-74.
21. William, M. and Wood, P. (1986) Neuromethods, Vol. 4 - Receptor Binding in Drug Discovery and Development, Totowa, NJ, Humana Press.
22. Galbraith, G.M.P. and Galbraith, R.M. (1981) Combined radiolabel-binding and immunocytochemical evaluation of receptor-ligand interactions - studies of transferrin receptors on activated lymphocytes. B iochemical Journal 200: 173-176.
23. Kirby, J., et al. (2007) Gene expression assays. Advances in Clinical Chemistry 44: 247-292.
24. Michael, S., et al. (2008) A robotic platform for quantitative high-throughput screening. Assay and Drug Development Technologies 6 (5): 637-657.
25. Wunder, F., et al. (2008) Functional cell-based assays in microliter volumes for ultra-high throughput screening. Combinational Chemistry & High Throughput Screen 11 (7): 495-504.
26. Yasgar, A., et al. (2008) Compound management for quantitative high-throughput screening. JALA, Charlottesville, VA 13 (2): 79-89.
27. Burdette, J.E., et al. (2002) Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. The Journal of Nutrition 132 (1): 27-30.
28. Burdette, J.E., et al. (2003) Black cohosh (Cimicifuga raceosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. Journal of Agricultural and Food Chemistry 50 (24): 7022-7028.
29. SeidlovÁ-Wuttke, D., et al. (2003) Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas 14 (44 Suppl. 1): S39-S50.