Tranexamic acid given into the wound reduces postoperative blood loss by half in major orthopaedic surgery

European Journal of Surgery, Supplement

Volumn 168, Issue 588, 2003, Pages 57-61

  Krohn, Claus Danckert ^a,b   Sørensen, Roger ^a   Lange, Johan Emil ^a   Riise, Rolf ^a   Bjørnsen, Stine ^a   Brosstad, Frank ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Drained blood; Fibrinolysis; Orthopaedic surgery; Tranexamic acid

Indexed keywords

ALPHA 2 ANTIPLASMIN; D DIMER; PLASMIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; ANTIPLASMIN; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

ADULT; AGED; ARTERIAL BLOOD; ARTICLE; BLEEDING; BONE SCREW; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EVALUATION; FEMALE; FIBRINOLYSIS; HUMAN; LOW BACK PAIN; LUMBAR SPINE; MALE; NORWAY; ORTHOPEDIC SURGERY; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SPINE STABILIZATION; STATISTICAL SIGNIFICANCE; SURGICAL DRAINAGE; TREATMENT OUTCOME; WOUND CLOSURE; BLOOD; LAVAGE; LUMBAR VERTEBRA; MIDDLE AGED; SPINE FUSION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; AGED; ANTIFIBRINOLYTIC AGENTS; ANTIPLASMIN; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; IRRIGATION; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; PLASMIN; POSTOPERATIVE HEMORRHAGE; SPINAL FUSION; TRANEXAMIC ACID;

EID: 0043166755     PISSN: 1102416X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Andersson L, Nilsson IM. AMCA (aminomethyl cyclohexane carboxylic acid, Cyclo-kapron) a potent haemostatic agent in urinary tract bleeding. Scand J Urol Nephrol 1969; 3: 169-176.
2. Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg 1996; 78 B: 434-440.
3. Benoni G, Fredin H, Knebel R, Nilsson P. Blood conservation with tranexamic acid in total hip arthroplasty: a randomized double blind study in 40 primary operations. Acta Orthop Scand 2001; 72: 442-448.
4. Benoni G, Lethagen S, Fredin H. The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty. Thromb Res 1997; 85: 195-206.
5. Benoni G, Lethagen S, Nilsson P, Fredin H. Tranexamic acid given at the end of the operation does not reduce blood loss in hip arthroplasty. Acta Orthop Scand 2000; 71: 250-254.
6. Coker N, Higgins DJ. Tranexamic acid applied topically to achieve haemostasis. Anaesthesia 2000; 55: 600-601.
7. Damji KF, Noel LP, Peterson RG et al. Topical versus intravenous administration of tranexamic acid: a comparison of intraocular and serum concentration in the rabbit. Can J Ophtalmol 1998; 33: 308-313.
8. De Bonis M, Cavaliere F, Alessandrini F, et al. Topical use of tranexamic acid in coronary artery bypass operations: a double-blind prospective, randomised, placebo-controlled study. J Thorac Cardiovasc Surg 2000; 119: 575-580.
9. Dunn CJ, Goa KL. Tranexamic acid: a review of its use and other indications. Drugs 1999; 57: 1005-1032.
10. Engel JM, Hohaus T, Ruwoldt R et al. Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anesth Analg 2001; 92: 775-780.
11. Ekbäck G, Axelsson K, Ryttberg L et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg 2000; 91: 1124-1130.
12. Hiippala S, Strid L, Wennerstrand M et al. Tranexamic acid (Cyclocapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995; 74: 534-537.
13. Horrow JC, Riper DF, Strong MD et al. The dose-response relationship of tranexamic acid. Anesthesiology 1995; 82: 383-392.
14. Klepfish A, Berrebi A, Schattner A. Intranasal tranexamic acid treatment for severe epistaxis in hereditary hemorrhagic telangiectasia. Arch Intern Med 2001; 161: 767.
15. Koo J-Y, Lee Y-K, Kim Y-S et al. Acute conical necrosis caused by an antifibrinolytic drug (tranexamic acid). Nephrol Dial Transplant 1999; 14: 750-752.
16. Kristiansson ME, Soop A, Keisu K et al. Local wound and systemic coagulation/ fibrinolysis response in hip arthroplasty. Acta Orthop Scand 1997; 68: 221-224.
17. Krohn CD, Reikerås O, Bjørnsen S, Brosstad F. Fibrinogen, fibrin and its degradation products in drained blood after major orthopaedic surgery. Blood Coagul Fibrinolysis 1999; 10: 167-171.
18. Mekontso-Dessap A, Collet JP, Lebrun-Vignes B et al. Acute myocardial infarction after oral tranexamic acid treatment initiation. Int J Cardiol 2002; 83: 267-268.
19. Neilipovitz DT, Murto K, Hall L et al. A randomised trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg 2001; 93: 82-87.
20. Odabas AR, Centinkaya R, Selcuk Y et al. Tranexamic-acid induced acute renal cortical necrosis in a patient with haemophilia A Nephrol Dial Transplant 2001; 16: 189-190.
21. Øvrum E, Holen EA, Abdelnoor M et al. Tranexamic acid (Cyklocapron) is not necessary to reduce blood loss after coronary artery bypass operations. J Thorac Cardiovasc Surg 1993; 105: 78-83.
22. Wegener T, Sandhagen B, Salden T. Effect of N-acetylcysteine on pulmonary damage due to microembolism in the rat. Eur J Respir Dis 1987; 70: 205-212.