Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats

Schizophrenia Research

Volumn 104, Issue 1-3, 2008, Pages 127-134

  Fatemi, S Hossein ^a   Folsom, Timothy D ^a   Reutiman, Teri J ^a   Pandian, Twinkle ^a,b   Braun, Natalie N ^a   Haug, Kari ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

Autism; Connexin 43; GFAP; Prefrontal cortex; Rat; Schizophrenia

Indexed keywords

CLOZAPINE; CONNEXIN 43; FLUOXETINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HALOPERIDOL; LITHIUM; OLANZAPINE; PSYCHOTROPIC AGENT; VALPROIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CONNEXIN 43; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; PREFRONTAL CORTEX; PSYCHOTROPIC DRUGS; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA;

EID: 50249181082     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2008.05.016     Document Type: Article

References (40)

1. Ahlsen G., Rosengren L., Belfrage M., Palm A., Haglid K., Hamberger A., and Gillberg C. Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biol. Psychiatry 33 10 (1993) 734-743
2. Bianchi M., Rossoni G., Sacerdote P., Panerai A.E., and Berti F. Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat. Inflamm. Res. 44 11 (1995) 466-469
3. Bonni A., Sun Y., Nadal-Vicens M., Bhatt A., Frank D.A., Rozovsky I., Stahl N., Yancopoulos G.D., and Greenberg M.E. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278 5337 (1997) 477-483
4. Butkevich E., Hülsmann S., Wenzel D., Shirao T., Duden R., and Majoul I. Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol. 14 8 (2004) 650-658
5. Colantuoni C., Jeon O.H., Hyder K., Chenchik C.A., Khimani A.H., Narayanan V., Hoffman E.P., Kaufmann W.E., Naidu S., and Pevsner J. Gene expression profiling in postmortem Rett syndrome brain: differential gene expression and patient classification. Neurobiol. Dis. 8 5 (2001) 847-865
6. Collignon F., Wetjen N.M., Cohen-Gadol A.A., Cascino G.D., Parisi J., Meyer F.B., Marsh W.R., Roche P., and Weigand S.D. Altered expression of connexin subtypes in mesial temporal lobe epilepsy in humans. J. Neurosurg. 105 1 (2006) 77-87
7. Cotrina M.L., Lin J.H., López-García J.C., Naus C.C., and Nedergaard M. ATP-mediated glia signaling. J. Neurosci. 20 8 (2000) 2835-2844
8. Delacourte A. General and dramatic glial reaction in Alzheimer brains. Neurology 40 1 (1990) 33-37
9. Eng L.F., and Ghirnikar R.S. GFAP and astrogliosis. Brain Pathol. 4 3 (1994) 229-237
10. Fatemi S.H., Emamiam E.S., Sidwell R.W., Kist D.A., Earle J., and Bailey K. Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice. Mol. Psychiatry 7 6 (2002) 633-640
11. Fatemi S.H., Laurence J.A., Araghi-Niknam M., Stary J.M., Schulz S.C., Lee S., and Gottesman I.I. Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia. Schiz. Res. 69 2-3 (2004) 317-323
12. Fatemi S.H., Folsom T.D., Reutiman T.J., and Lee S. Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism. Synapse 62 7 (2008) 501-507
13. Gao X.M., Hashimoto T., Cooper T.B., and Tamminga C.A. The dose-response characteristics of rat oral dyskinesias with chronic haloperidol or clozapine administration. J. Neural Transm. 104 1 (1997) 97-104
14. Giaume C., Fromaget C., el Aoumari A., Cordier J., Glowinski J., and Gros D. Gap junctions in cultured astrocytes: single-channel currents and characterization of channel-forming protein. Neuron 6 1 (1991) 133-143
15. Ghirnikar R., Yu A., and Eng L. Astrogliosis in culture: III. Effect of recombinant retrovirus expressing antisense glial fibrillary acidic protein RNA. J. Neurosci. Res. 38 4 (1994) 376-385
16. Kim H.J., Rowe M., Ren M., Hong J.S., Chen P.S., and Chuang D.M. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J. Pharmacol. Exp. Ther. 321 3 (2007) 892-901
17. Laurence J.A., and Fatemi S.H. Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum 4 3 (2005) 206-210
18. Liedtke W., Edelmann W., Bieri L.P., Chiu F.-C., Cowman J.N., Kucherlapati R., and Raine S.C. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 17 4 (1996) 607-615
19. McCall A.M., Gregg G.R., Behringer R.R., Brenner M., Delaney G.C., Galbreath J.E., Zhang L.C., Pearce A.R., Chiu Y.S., and Messing A. Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc. Nat. Acad. Sci. USA 93 13 (1996) 6361-6366
20. Nakase T., Yoshida Y., and Nagata K. Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia. Glia 54 5 (2006) 369-375
21. Naus C.C., Bechberger J.F., Caveney S., and Wilson J.X. Expression of gap junction genes in astrocytes and C6 glioma cells. Neurosci. Lett. 126 1 (1991) 33-36
22. Nedergaard M., Ransom B., and Goldman S.A. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26 10 (2003) 523-530
23. Nejadkey F., Nahavandi A., Dehpour A.R., and Mani A.R. Role of nitric oxide in the gastro-protective effect of lithium. Pathophysiology 13 2 (2006) 85-89
24. Nicchia G.P., Srinivas M., Lei W., Brosnan C.F., Frigeri A., and Spray D.C. New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J. 19 12 (2005) 1674-1676
25. Radewicz K., Garey L.J., Gentleman S.M., and Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J. Neuropathol. Exp. Neurol. 59 2 (2000) 137-150
26. Rajkowska G., Miguel-Hidalgo J.J., Makkos Z., Meltzer H., Overholser J., and Stockmeier C. Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia. Schizophr. Res. 57 2-3 (2002) 127-138
27. Reaume A.G., de Sousa P.A., Kulkarni S., Langille B.L., Zhu D., Davies T.C., Juneja S.C., Kidder G.M., and Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 267 5205 (1995) 1831-1834
28. Ren M., Leng Y., Jeong M.R., Leeds P.R., and Chuang D.M. Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J. Neurochem. 89 6 (2004) 1358-1367
29. Roberts R.C. Effect of chronic olanzapine treatment on striatal synaptic organization. Synapse 39 1 (2001) 8-15
30. Rocha E., and Rodnight R. Chronic administration of lithium chloride increases immunodetectable glial fibrillary acidic protein in the rat hippocampus. J. Neurochem. 63 4 (1994) 1582-1584
31. Rosengren L.E., Ahlsen G., Belfrage M., Gillberg C., Haglid K.G., and Hamberger A. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children. J. Neurosci. Methods 44 2-3 (1992) 113-119
32. Rouach N., Avignone E., Meme W., Koulakoff A., Venance L., Blomstrand E., and Giaume C. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol. Cell. 94 7-8 (2002) 457-475
33. Singh V.K., Warren R., Averett R., and Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr. Neurol. 17 1 (1997) 88-90
34. Sohl G., Maxeiner S., and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 6 3 (2005) 191-200
35. Theis M., Speidel D., and Willecke K. Astrocyte cultures from conditional connexin43-deficient mice. Glia 46 2 (2004) 130-141
36. Toro C.T., Hallak J.E., Dunham J.S., and Deakin J.F. Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder. Neurosci. Lett. 404 3 (2006) 276-281
37. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., and Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57 1 (2005) 67-81
38. Webster M.J., Knable M.B., Johnston-Wilson N., Nagata K., Inagaki M., and Yolken R.H. Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression. Brain Behav. Immun. 15 4 (2001) 388-400
39. Webster M.J., O'Grady J., Kleinman J.E., and Weickert C.S. Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 133 2 (2005) 453-461
40. Wiencken-Barger A.E., Djukic B., Casper K.B., and McCarthy K.D. A role for Connexin43 during neurodevelopment. Glia 55 7 (2007) 675-686