Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment

Neurobiology of Learning and Memory

Volumn 105, Issue , 2013, Pages 54-62

  Su, Susan C ^a   Rudenko, Andrii ^a   Cho, Sukhee ^a   Tsai, Li Huei ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cdk5; Cognitive function; Hyperactivity; Lithium; Open field; Transmitter release

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PHOSPHOPROTEIN PHOSPHATASE 2A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN SYNAPTOSOME; COGNITIVE DEFECT; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEAR; FOREBRAIN; HELPLESSNESS; HIPPOCAMPUS; HYPERACTIVITY; MANIA; MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; OPEN FIELD TEST; PREPULSE INHIBITION; PROTEOMICS; PYRAMIDAL NERVE CELL; SPATIAL LEARNING; SYNAPTIC TRANSMISSION;

CDK5; COGNITIVE FUNCTION; HYPERACTIVITY; LITHIUM; OPEN FIELD; TRANSMITTER RELEASE;

ANIMALS; COGNITION; CYCLIN-DEPENDENT KINASE 5; GENE KNOCKOUT TECHNIQUES; HYPERKINESIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROSENCEPHALON; PYRAMIDAL CELLS;

EID: 84884142238     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2013.06.016     Document Type: Article

References (23)

1. Beaulieu J.M., Marion S., Rodriguiz R.M., Medvedev I.O., Sotnikova T.D., Ghisi V., et al. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 2008, 132:125-136.
2. Chae T., Kwon Y.T., Bronson R., Dikkes P., Li E., Tsai L.H. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 1997, 18:29-42.
3. Dhavan R., Tsai L.H. A decade of CDK5. Nature Reviews Molecular Cell Biology 2001, 2:749-759.
4. Drerup J.M., Hayashi K., Cui H., Mettlach G.L., Long M.A., Marvin M., et al. Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35. Biological Psychiatry 2010, 68:1163-1171.
5. Engmann O., Hortobagyi T., Pidsley R., Troakes C., Bernstein H.G., Kreutz M.R., et al. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain 2011, 134:2408-2421.
6. Fischer A., Sananbenesi F., Pang P.T., Lu B., Tsai L.H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 2005, 48:825-838.
7. Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J. Cyclin-dependent kinase 5 is required for associative learning. Journal of Neuroscience 2002, 22:3700-3707.
8. Guan J.S., Su S.C., Gao J., Joseph N., Xie Z., Zhou Y., et al. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS ONE 2011, 6:e25735.
9. Hawasli A.H., Benavides D.R., Nguyen C., Kansy J.W., Hayashi K., Chambon P., et al. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nature Neuroscience 2007, 10:880-886.
10. Hawasli A.H., Koovakkattu D., Hayashi K., Anderson A.E., Powell C.M., Sinton C.M., et al. Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5. PLoS ONE 2009, 4:e5808.
11. Kim S.H., Ryan T.A. CDK5 serves as a major control point in neurotransmitter release. Neuron 2010, 67:797-809.
12. Krapacher F.A., Mlewski E.C., Ferreras S., Pisano V., Paolorossi M., Hansen C., et al. Mice lacking p35 display hyperactivity and paradoxical response to psychostimulants. Journal of Neurochemistry 2010, 114:203-214.
13. Li B.S., Sun M.K., Zhang L., Takahashi S., Ma W., Vinade L., et al. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:12742-12747.
14. Mitra A., Mitra S.S., Tsien R.W. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Nature Neuroscience 2011, 250-257.
15. Morabito M.A., Sheng M., Tsai L.H. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. Journal of Neuroscience 2004, 24:865-876.
16. Plattner F., Angelo M., Giese K.P. The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. Journal of Biological Chemistry 2006, 281:25457-25465.
17. Prickaerts J., Moechars D., Cryns K., Lenaerts I., van Craenendonck H., Goris I., et al. Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. Journal of Neuroscience 2006, 26:9022-9029.
18. Samuels B.A., Hsueh Y.P., Shu T., Liang H., Tseng H.C., Hong C.J., et al. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56:823-837.
19. Seeburg D.P., Feliu-Mojer M., Gaiottino J., Pak D.T., Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 2008, 58:571-583.
20. Shaltiel G., Maeng S., Malkesman O., Pearson B., Schloesser R.J., Tragon T., et al. Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Molecular Psychiatry 2008, 13:858-872.
21. Su S.C., Tsai L.H. Cyclin-dependent kinases in brain development and disease. Annual Review of Cell and Developmental Biology 2011, 27:465-491.
22. Weber P., Metzger D., Chambon P. Temporally controlled targeted somatic mutagenesis in the mouse brain. European Journal of Neuroscience 2001, 14:1777-1783.
23. Zeng H., Chattarji S., Barbarosie M., Rondi-Reig L., Philpot B.D., Miyakawa T., et al. Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell 2001, 107:617-629.