DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients

Schizophrenia Research

Volumn 150, Issue 1, 2013, Pages 312-318

  Auta, J ^a   Smith, R C ^b,c   Dong, E ^a   Tueting, P ^a   Sershen, H ^b,c   Boules, S ^b   Lajtha, A ^b,c   Davis, J ^a   Guidotti, A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain derived neurotrophic factor (BDNF); DNA demethylation; DNA methyltransferase (DNMT); Epigenetic; Glucocorticoid receptor (GCortR); Ten eleven translocation hydroxylase (TET)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CARRIER PROTEIN; DNA METHYLTRANSFERASE 1; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; METHYLCYTOSINE DEOXYGENASE; TEN ELEVEN TRANSLOCATOR 1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DNA SPLICING; DOWN REGULATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME STRUCTURE; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE NETWORK DYSREGULATION; GENE TARGETING; GENETIC DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SCHIZOPHRENIA;

BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF); DNA DEMETHYLATION; DNA METHYLTRANSFERASE (DNMT); EPIGENETIC; GLUCOCORTICOID RECEPTOR (GCORTR); TEN-ELEVEN-TRANSLOCATION HYDROXYLASE (TET);

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE REGULATORY NETWORKS; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SCHIZOPHRENIA; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 84884131438     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.07.030     Document Type: Article

References (42)

1. Andersen C.L., Jensen J.L., Orntoft T.F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer 2004, 64:5245-5250.
2. Cross-Disorder Group of the Psychiatric Genomics Consortium Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013, (doi: 10.1016, Feb 28).
3. Davies M.N., Volta M., Pidsley R., Lunnon K., Dixit A., Lovestone S., Coarfa C., Harris R.A., Milosavljevic A., Troakes C., Al-Sarraj S., Dobson R., Schalkwyk L.C., Mill J. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 2012, 13(R43). 10.1186/gb-2012-13-6-r43.
4. Dempster E.L., Pidsley R., Schalkwyk L.C., Owens S., Georgiades A., Kane F., Kalidindi S., Picchioni M., Kravariti E., Toulopoulou T., Murray R.M., Mill J. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum. Mol. Genet. 2011, 20:4786-4796.
5. Dong E., Gavin D.P., Chen Y., Davis J. Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients. Transl. Psychiatry 2012, 2(e159). (Sep 4).
6. Gavin D.P., Sharma R.P., Chase K.A., Matrisciano F., Dong E., Guidotti A. Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology 2012, 37:531-542.
7. Goll M.G., Bestor T.H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 2005, 74:481-514.
8. Grayson D.R., Guidotti A. The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology 2013, 38:138-166.
9. Guidotti A., Auta J., Chen Y., Davis J.M., Dong E., Gavin D.P., Grayson D.R., Matrisciano F., Pinna G., Satta R., Sharma R.P., Tremolizzo L., Tueting P. Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropsychopharmacology 2011, 60:1007-1016.
10. Guo J.U., Su Y., Zhong C., Ming G.L., Song H. Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond. Cell Cycle 2011, 10:2662-2668.
11. Houston I., Peter C.J., Mitchell A., Straubhaar J., Rogaev E., Akbarian S. Epigenetics in the human brain. Neuropsychopharmacology 2013, 38:183-197.
12. Kadriu B., Guidotti A., Chen Y., Grayson D.R. DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in GAD67-GFP mouse brain. J. Comp. Neurol. 2012, 520:1951-1964.
13. Klengel T., Mehta D., Anacker C., Haffner M.R., Pruessner J.C., Pariante C.M., Pace T.W.W., Mercer K.B., Mayberg H.S., Bradley B., Nemeroff C.B., Holsber F., Heim C.M., Ressler K.J., Rein T., Binder E.B. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions 2012, 16(1):33-44.
14. Labonté B., Suderman M., Maussion G., Navaro L., Yerko V., Mahar I., Bureau A., Mechawar N., Szyf M., Meaney M.J., Turecki G. Genome-wide epigenetic regulation by early-life trauma. Genome-wide epigenetic regulation by early-life trauma. Arch. Gen. Psychiatry 2012, 69:722-731.
15. Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005, 6:312-324.
16. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
17. Ma D.K., Jang M.H., Guo J.U., Kitabatake Y., Chang M.L., Pow-Anpongkul N., Flavell R.A., Lu B., Ming G.L., Song H. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 2009, 323:1074-1077.
18. Maloku E., Kadriu B., Zhubi A., Dong E., Pibiri F., Satta R., Guidotti A. Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology 2011, 36:1366-1374.
19. Mannhalter C., Kolzar D., Mitterbauer G. Evaluation of RNA isolation methods and reference genes for RT-PCR analyses of rare target RNA. Clin. Chem. Lab. Med. 2000, 38(2):171-177.
20. McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonté B., Szyf M., Turecki G., Meaney M.J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 2009, 12:342-348.
21. Mellén M., Ayata P., Dewell S., Kriaucionis S., Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 2012, 151:1417-1430.
22. Michel M., Schmidt M.J., Mirnics K. Immune system gene dysregulation in autism and schizophrenia. Dev. Neurobiol. 2012, 72:1277-1287.
23. Mill J., Tang T., Kaminsky Z., Khare T., Yazdanpanah S., Bouchard L., Jia P., Assadzadeh A., Flanagan J., Schumacher A., Wang S.C., Petronis A. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am. J. Hum. Genet. 2008, 82:696-711.
24. Moore L.D., Le T., Fan G. DNA methylation and its basic function. Neuropsychopharmacology 2013, 38:23-38.
25. Ooi S.K., Bestor T.H. The colorful history of active DNA demethylation. Cell 2008, 133:1145-1148.
26. Provençal N., Suderman M.J., Guillemin C., Massart R., Ruggiero A., Wang D., Bennett A.J., Pierre P.J., Friedman D.P., CÔté S.M., Hallett M., Tremblay R.E., Suomi S.J., Szyf M. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J. Neurosci. 2012, 32:15626-15642.
27. Ptak C., Petronis A. Epigenetics and complex disease: from etiology to new therapeutics. Annu. Rev. Pharmacol. Toxicol. 2008, 48:257-276.
28. Reinius L.E., Acevedo N., Joerink M., Pershagen G., Dahlén S.E., Greco D., Söderhäll C., Scheynius A., Kere J. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One 2012, 7(7):e41361. (Epub Jul 25). 10.1371/journal.pone.0041361.
29. Roth T.L., Lubin F.D., Sodhi M., Kleinman J.E. Epigenetic mechanisms in schizophrenia. Biochim. Biophys. Acta 2009, 1790:869-877.
30. Ruzicka W.B., Zhubi A., Veldic M., Grayson D.R., Costa E., Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol. Psychiatry 2007, 12:385-397.
31. Satta R., Maloku E., Zhubi A., Pibiri F., Hajos M., Costa E., Guidotti A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:16356-16361.
32. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 2008, 3(6):1101-1108.
33. Shen L., Zhang Y. 5-Hydroxymethylcytosine: generation, fate, and genomic distribution. Curr. Opin. Cell Biol. 2013, 25:289-296.
34. Sinclair D., Tsai S.Y., Woon H.G., Weickert C.S. Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness. Neuropsychopharmacology 2011, 36:2698-2709.
35. Sinclair D., Webster M.J., Fullerton J.M., Weickert C.S. Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder. BMC Psychiatry 2012, 20:12-84.
36. Smith R., Lindenmayer J., Davis J., Kelly E., Viviano T., Cornwell J., Hu Q., Khan A., Vaidhyanathaswamy S. Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month study. J. Clin. Psychiatry 2009, 70:1501-1513.
37. Smith R., Lindenmayer J.-P., Hu Q., Kelly E., Viviano T., Cornwell J., Vaidhyanathaswamy S., Marcovina S., Davis J. Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month study. Schizophr. Res. 2010, 120:204-209.
38. Veldic M., Caruncho H.J., Liu W.S., David J., Satta R., Grayson D.R., Guidotti A., Costa E. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of Schizophrenia brains. Proc. Natl. Acad. Sci. USA 2004, 101(1):348-353.
39. Wong J., Hyde T.M., Cassano H.L., Deep-Soboslay A., Kleinman J.E., Weickert C.S. Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia. Neuroscience 2010, 169:1071-1084.
40. Zhang T.Y., Labonté B., Wen X.L., Turecki G., Meaney M.J. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology 2013, 38:111-113.
41. Zhu J.K. Active DNA demethylation mediated by DNA glycosylases. Annu. Rev. Genet. 2009, 43:143-166.
42. Zhubi A., Veldic M., Puri N.V., Kadriu B., Caruncho H., Loza I., Sershen H., Lajtha A., Smith R.C., Guidotti A., Davis J.M., Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophr. Res. 2009, 111:115-122.