Hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-PEG-gelatin polymer nanocomposites as targeted and controlled drug delivery vehicles

International Journal of Pharmaceutics

Volumn 453, Issue 2, 2013, Pages 514-522

  Rajan, M ^a   Raj, V ^a   Al Arfaj, Abdullah A ^b   Murugan, A M ^b  

^a PERIYAR UNIVERSITY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

5 Fluorouracil; Chitosan; Drug delivery; Encapsulation; Gelatin; Hyaluronidase

Indexed keywords

CHITOSAN; FLUOROURACIL; GELATIN; HYALURONIDASE; MACROGOL; NANOCOMPOSITE; NANOPARTICLE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; INFRARED SPECTROMETRY; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

EID: 84884125673     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.06.030     Document Type: Article

References (50)

1. Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O., Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A., Lapidot, T., 2004. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103, 2981-2989. (Pubitemid 38451670)
2. Beckenlehner, K., Bannke, S., Spruss, T., Bernhardt, G., Schonenberger, H., Schiess, W., 1992. Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo. J. Cancer Res. Clin. Oncol. 118, 591-596.
3. Belem-Gonçalves, S., Tsan, P., Lancelin, J.M., Alves, T.L., Salim, V.M., Besson, F., 2006. Interfacial behaviour of bovine testis hyaluronidase. Biochem. J. 398, 569-576. (Pubitemid 44453402)
4. Bhattarai, N., Matsen, F.A., Zhang, M., 2005. PEG-grafted chitosan as an injectable thermoreversible hydrogel. Macromol. Biosci. 5, 107-111. (Pubitemid 40803835)
5. Bigi, A., Cojazzi, G., Panzavolta, S., Roveri, N., Rubini, K., 2006. Stabilization of gelatin films by crosslinking with genipin. Biomaterials 23, 4827-4832.
6. Bookbinder, L.H., Hofer, A., Haller, M.F., Zepeda, M.L., Keller, G.A., Lim, J.E., Edgington, T.S., Shepard, H.M., Patton, J.S., Frost, G.I., 2006. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J. Control. Release 114, 230-241. (Pubitemid 44291844)
7. Boucher, Y., Leunig, M., Jain, R.K., 1996. Tumor angiogenesis and interstitial hypertension. Cancer Res. 56, 4264-4266. (Pubitemid 26305026)
8. Chang, N.S., 1998. Transforming growth factor-beta protection of cancer cells against tumor necrosis factor cytotoxicity is counteracted by hyaluronidase. Int. J. Mol. Med. 2, 653-659 (review).
9. Choi, Y.S., Lee, S.B., Hong, S.R., Lee, Y.M., Song, K.W., Park, M.H., 2001. Studies on gelatin based sponges. Part III. A comparative study of cross-linked gelatin/alginate, gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat. J. Mater. Sci. Mater. Med. 12, 67-73. (Pubitemid 32108411)
10. Croix, B.S., Rak, J.W., Kapitain, S., Sheehan, C., Graham, C.H., Kerbel, R.S., 1996. Reversal by hyaluronidase of adhesion dependent multicellular drug resistance in mammary carcinoma cells. J. Natl. Cancer Inst. 88, 1285-1296. (Pubitemid 26301616)
11. Dal, P.A., Vanini, L., Fagnoni, M., Guerrini, M., Benedittis, D.A., Muzzarelli, R.A.A., 2000. Preparation and characterization of poly(ethylene glycol)-crosslinked reacetylated chitosans. Carbohydr. Polym. 42, 201-206. (Pubitemid 32133077)
12. Frank, S., Lauterbur, P.C., 1993. Voltage-sensitive magnetic gels as magnetic resonance monitoring agents. Nature 363, 334-336.
13. Gao, F., Okunieff, P., Han, Z., 2005. Hypoxia-induced alterations in hyaluronan and hyaluronidase. Adv. Exp. Med. Biol. 566, 249-256. (Pubitemid 43779509)
14. George, M., Abraham, T.E., 2006. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J. Control. Release 114, 1-14. (Pubitemid 44131680)
15. Hagiwara, S., Kudo, M., Nakatani, T., Sakaguchi, Y., Nagashima, M., Fukuta, N., Kimura, M., Hayakawa, S., Munakata, H., 2007. Combination therapy with PEG-IFN-α and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. Br. J. Cancer 97, 1532-2153.
16. Henry, B., Duling, B.R., 1999. Permeation of the luminal capillary glycocalyx is determined by hyaluronan. Am. J. Physiol. 277, 508-514.
17. Ibrahim, S., Kang, Q.K., Ramamurthi, A., 2010. The impact of hyaluronic acid oligomer content on physical, mechanical, and biologic properties of divinyl sulfone-crosslinked hyaluronic acid hydrogels. J. Biomed. Mater. Res. A 94, 355-370.
18. Jeong, Y., Kim, D.G., Jang, M.K., Nah, J.W., 2008. Preparation and spectroscopic characterization of methoxy poly(ethylene glycol)-grafted water-soluble chitosan. Carbohydr. Res. 343, 282-289.
19. Junker, N., Latini, L.N., Petersen, L.N., Kristjansen, P.E.G., 2003. Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncol. Rep. 10, 609-616.
20. Kass, H., Seastone, C.V., 1944. The role of the mucoid polysaccharide (hyaluronic acid) in the virulence of group a hemolytic streptococci. J. Exp. Med. 79, 319-330.
21. Kohno, N., Ohnuma, T., Truog, P., 1994. Effects of hyaluronidase on doxorubicin penetration into squamous carcinoma multicellular tumor spheroids and its cell lethality. J. Cancer Res. Clin. Oncol. 120, 293-297. (Pubitemid 24067642)
22. Korsmeyer, R.C., Peppas, N.A., 1981. Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs. J. Membr. Sci. 9, 211-227. (Pubitemid 12253072)
23. Langer, R., 1998. Drug delivery and targeting. Nature 392, 5-10. (Pubitemid 28215187)
24. Larson, N., Gormley, A., Frazier, N., Ghandehari, H., 2013. Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia. J. Control. Release 170, 41-50.
25. Li, P.W., Wang, Y.C., Zeng, F.B., Chen, L.J., Peng, Z., Kong, L.X., 2011a. Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells. Carbohydr. Res. 346, 801-806.
26. Li, P., Wang, Y., Peng, Z., She, F., Kong, L., 2011b. Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends. Carbohydr. Polym. 85, 698-704.
27. Lin, F., Yao, C.H., Sun, J.S., Liao, C., Huang, C., 1998. Biological effects and cytotoxicity of tricalcium phosphate and formaldehyde crosslinked gelatin composite. Mater. Chem. Phys. 45, 6-14.
28. Lin, Y., Chen, Q., Luo, H., 2007. Preparation and characterization of N-(2-carboxybenzyl) chitosan as a potential pH-sensitive hydrogel for drug delivery. Carbohydr. Res. 342, 87-94.
29. Matousek, J., Pouckova, P., Hlouskova, D., Zadinova, M., Soucek, J., Skvor, J., 2004. Effect of hyaluronidase and PEG chain conjugation on the biologic and antitumor activity of RNase A. J. Control. Release 94, 401-410. (Pubitemid 38117150)
30. Mi, F.L., Sung, H.W., Shyu, S.S., 2002. Drug release from chitosan-alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohydr. Polym. 48, 61-72.
31. Muckenschnabel, L., Bernhardt, G., Spruss, T., Dietl, B., Buschauer, A., 1998. Quantitation of hyaluronidases by the Morgan-Elson reaction: comparison of the enzyme activities in the plasma of tumor patients and healthy volunteers. Cancer Lett. 131, 13-20. (Pubitemid 28467036)
32. Muzzarelli, R.A.A., Tanfani, F., Marriotti, S., Emanuelli, M., 1982. N-(o-carboxybenzyl) chitosans: novel chelating polyampholytes. Carbohydr. Polym. 2, 145-157.
33. Nedvetzki, S., Gonen, E., Assayang, N., 2004. RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc. Natl. Acad. Sci. U.S.A. 101, 18081-18086. (Pubitemid 40054077)
34. Papadimitriou, S., Bikiaris, D., Avgoustakis, K., Karavas, E., Georgarakis, M., 2008. Chitosan nanoparticles loaded with dorzolamide and pramipexole. Carbohydr. Polym. 73, 44-54.
35. Prestwich, G.D., Marecak, D.M., Marecek, J.F., Vercruysse, K.P., Ziebell, M.R., 1998. Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives. J. Control. Release 53, 93-103. (Pubitemid 28218693)
36. Rajan, M., Raj, V., 2012. Encapsulation, characterisation and in-vitro release of anti-tuberculosis drug using chitosan-poly ethylene glycol nanoparticles. Int. J. Pharm. Pharm. Sci. 4, 255-259.
37. Rathbone, M.J., Witchey-Lakshmanan, L., Ciftci, K., 1999. Veterinary application. In: Mathiowitz, E. (Ed.), Encyclopedia of Controlled Drug Delivery. Wiley, New York, pp. 1007-1037.
38. Schante, C., Zuber, G., Herlin, C., Vandamme, T.F., 2012. Improvement of hyaluronic acid enzymatic stability by the grafting of amino-acids. Carbohydr. Polym. 87, 2211-2216.
39. Shi, J., Votruba, A.R., Farokhzad, O.C., Langer, R., 2010. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 10, 3223-3230.
40. Shuster, S., Frost, G.I., Csuka, A.B., Formby, B., Stern, R., 2002. Hyaluronidase reduces breast cancer xenografts in scid mice. Int. J. Cancer 102, 192-197. (Pubitemid 35168035)
41. Smith, K.J., Skelton, H.G., Turiansky, G., Wagner, K.F., 1997. Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma. J. Am. Acad. Dermatol. 36, 239-242. (Pubitemid 27078919)
42. Stern, R., 2003. Devising a pathway for hyaluronan catabolism: are we there yet. Glycobiology 13, 105R-115R. (Pubitemid 37508893)
43. Stern, R., Shuster, S., Wiley, T.S., Forby, B., 2001. Hyaluronidase can modulate expression of CD44. Exp. Cell Res. 266, 167-176. (Pubitemid 32989053)
44. Tolksdorf, S., McCready, M., McCullagh, D., Schwenk, E., 1949. The turbidimetric assay of hyaluronidase. J. Lab. Clin. Med. 34, 74-89.
45. Tomihata, K., Ikada, Y., 1997. Crosslinking of hyaluronic acid with water-soluble carbodiimide. J. Biomed. Mater. Res. 37, 243-251. (Pubitemid 27467667)
46. Wittaya-areekul, S., Kruenate, J., Prahsarn, C., 2006. Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. Int. J. Pharm. 312, 113-118.
47. Yin, Y.J., Yao, K.D., Cheng, G.X., Ma, J.B., 1999. Properties of polyelectrolyte complex films of chitosan and gelatin. Polym. Int. 48, 429-433.
48. Zhang, Y.Z., Venugopal, J., Huang, Z.M., Lim, C.T., Ramakrishna, S., 2006. Cross linking of the electrospun gelatin nanofibers. Polymer 47, 2911-2917.
49. Zhang, Y., Chen, J., Zhang, Y.D., Pan, Y., Zhao, J., Ren, L., 2007. A novel PEGylation of chitosan nanoparticles for gene delivery. Biotechnol. Appl. Biochem. 46, 197-204. (Pubitemid 46587489)
50. Zhu, H., Mitsuhashi, N., Klein, A., 2006. The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells 24, 928-935. (Pubitemid 44464726)