Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia

Journal of Controlled Release

Volumn 170, Issue 1, 2013, Pages 41-50

  Larson, Nate ^a   Gormley, Adam ^a,b   Frazier, Nick ^a,b   Ghandehari, Hamidreza ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

Gold nanorods; GRP78; HPMA copolymers; Hyperthermia; Prostate cancer; Targeted drug delivery

Indexed keywords

BINS; CELL MEMBRANES; CELLS; CYTOLOGY; DISEASES; DRUG THERAPY; GOLD; HYPERTHERMIA THERAPY; MEDICAL NANOTECHNOLOGY; NANORODS; PEPTIDES; PLASMONS; PLATINUM COMPOUNDS; PROTEINS; TUMORS; UROLOGY;

GOLD NANOROD; GRP78; HPMA COPOLYMERS; HYPERTHERMIA; PROSTATE CANCERS;

TARGETED DRUG DELIVERY;

AMINOHEXYLGELDANAMYCIN; CISPLATIN; COPOLYMER; DOCETAXEL; GELDANAMYCIN; GLUCOSE REGULATED PROTEIN 78; GOLD NANOPARTICLE; GOLD NANOROD; HEAT SHOCK PROTEIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE; NANOROD; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL SURFACE; CONJUGATE; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NANOFABRICATION; NONHUMAN; PHOTOTHERAPY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN TARGETING; SINGLE DRUG DOSE; TUMOR REGRESSION;

EID: 84878303070     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.04.006     Document Type: Article

References (32)

1. T. Lammers, F. Kiessling,W.E.Hennink, G Storm, Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress, J. Control. Release 161 (2012) 175-187.
2. J.D. Byrne, T. Betancourt, L. Brannon-Peppas, Active targeting schemes for nanoparticle systems in cancer therapeutics, Adv. Drug Deliv. Rev. 60 (2008) 1615-1626.
3. D.B. Pike, H. Ghandehari, HPMA copolymer-cyclic RGD conjugates for tumor targeting, Adv. Drug Deliv. Rev. 62 (2010) 167-183.
4. M.P. Borgman, O. Aras, S. Geyser-Stoops, E.A. Sausville, H. Ghandehari, Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery, Mol. Pharm. 6 (2009) 1836-1847.
5. T.A. Denison, Y.H. Bae, Tumor heterogeneity and its implication for drug delivery, J. Control. Release 164 (2012) 187-191.
6. J.M. Adams, A. Strasser, Is tumor growth sustained by rare cancer stem cells or dominant clones? Cancer Res. 68 (2008) 4018-4021.
7. M. Shackleton, E. Quintana, E.R. Fearon, S.J. Morrison, Heterogeneity in cancer: cancer stem cells versus clonal evolution, Cell 138 (2009) 822-829.
8. A. Hopper-Borge, R.E. Nasto, V. Ratushny, L.M. Weiner, E.A. Golemis, I. Astsaturov, Mechanisms of tumor resistance to EGFR-targeted therapies, Expert Opin. Ther. Targets 13 (2009) 339-362.
9. A.J. Gormley, N. Larson, S. Sadekar, R. Robinson, A. Ray, H. Ghandehari, Guided delivery of polymer therapeutics using plasmonic photothermal therapy, Nano Today 7 (2012) 158-167.
10. A.J.Gormley, K.Greish,A. Ray, R. Robinson, J.A.Gustafson,H.Ghandehari, Gold nanorod mediated plasmonic photothermal therapy: a tool to enhance macromolecular delivery, Int. J. Pharm. 415 (2011) 315-318.
11. A.J. Gormley, N. Larson, A. Banisadr, R. Robinson, N. Frazier, A. Ray, H. Ghandehari, Plasmonic photothermal therapy increases the tumor mass penetration of HPMA copolymers, J. Control. Release 166 (2013) 130-138.
12. K. Richter, M. Haslbeck, J. Buchner, The heat shock response: life on the verge of death, Mol. Cell 40 (2010) 253-266.
13. Z. Nahleh, A. Tfayli, A. Najm, A. El Sayed, Z. Nahle, Heat shock proteins in cancer: targeting the 'chaperones', Future Med. Chem. 4 (2012) 927-935.
14. D.S. Hong, U. Banerji, B. Tavana, G.C. George, J. Aaron, R. Kurzrock, Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions, Cancer Treat. Rev. 39 (2013) 375-387.
15. Y.G. Shellman, W.R. Howe, L.A. Miller, N.B. Goldstein, T.R. Pacheco, R.L. Mahajan, S.M. LaRue, D.A. Norris, Hyperthermia induces endoplasmic reticulum-mediated apoptosis in melanoma and non-melanoma skin cancer cells, J. Invest. Dermatol. 128 (2008) 949-956. (Pubitemid 351374306)
16. X. Xu, S. Gupta, W. Hu, B.C. McGrath, D.R. Cavener, Hyperthermia induces the ER stress pathway, PLoS One 6 (2011) e23740.
17. M. Ni, Y. Zhang, A.S. Lee, Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting, Biochem. J. 434 (2011) 181-188.
18. S. Link, M.A. El-Sayed, Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals, Int. Rev. Phys. Chem. 19 (2000) 409-453.
19. M.A. Arap, J. Lahdenranta, P.J. Mintz, A. Hajitou, A.S. Sarkis, W. Arap, R. Pasqualini, Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands, Cancer Cell 6 (2004) 275-284. (Pubitemid 39222040)
20. J.M. Walker, The Protein Protocols Handbook, Humana Press, Towota, N.J., 1996
21. B. Nikoobakht, M.A. El-Sayed, Preparation and growthmechanismof gold nanorods (NRs) using seed-mediated growth method, Chem. Mater. (2003) 1957-1962.
22. J. Strohalm, J. Kopecek, PolyN-(2-hydroxypropyl)methacrylamide: 4. Heterogenous polymerization, Angew. Makromol. Chem. 70 (1978) 109-118.
23. J. Labsky Rejmanova, J. Kopecek, Aminolyses of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids, Makromol. Chem. 178 (1977) 2159-2168.
24. K. Ulbrich, V. Subr, J. Strohalm, D. Plocova, M. Jelinkova, B. Rihova, Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation, J. Control. Release 64 (2000) 63-79. (Pubitemid 30035308)
25. J.H. Lee, P. Kopeckova, J. Kopecek, J.D. Andrade, Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings, Biomaterials 11 (1990) 455-464. (Pubitemid 20329103)
26. A. Ray, N. Larson, D.B. Pike, M. Gruner, S. Naik, H. Bauer, A. Malugin, K. Greish, H. Ghandehari, Comparison of active and passive targeting of docetaxel for prostate cancer therapy by HPMA copolymer-RGDfK conjugates, Mol. Pharm. 8 (2011) 1090-1099.
27. Y. Kasuya, Z.R. Lu, P. Kopeckova, S.E. Tabibi, J. Kopecek, Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates, Pharm. Res. 19 (2002) 115-123. (Pubitemid 34168208)
28. T.C. Chou, P. Talalay, Quantitative analysis of dose-effect relationships: the combined effects ofmultiple drugs or enzyme inhibitors, Adv. Enzyme Regul. 22 (1984) 27-55.
29. L.W. Seymour, R. Duncan, J. Strohalm, J. Kopecek, Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats, J. Biomed. Mater. Res. 21 (1987) 1341-1358.
30. K. Greish, A. Ray, H. Bauer, N. Larson, A. Malugin, D. Pike, M. Haider, H. Ghandehari, Anticancer and antiangiogenic activity of HPMA copolymeraminohexylgeldanamycin- RGDfK conjugates for prostate cancer therapy, J. Control. Release 151 (2011) 263-270.
31. E. Gianasi,M.Wasil, E.G. Evagorou, A. Keddle, G.Wilson, R. Duncan,HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo, Eur. J. Cancer 35 (1999) 994-1002. (Pubitemid 29277137)
32. S. Ohno, Z.H. Siddik, Y. Kido, L.A. Zwelling, J.M. Bull, Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells, Cancer Chemother. Pharmacol. 34 (1994) 302-306. (Pubitemid 24216535)