Aging and the Skin

Brocklehurst's Textbook of Geriatric Medicine and Gerontology

Volumn , Issue , 2010, Pages 133-137

  Veysey, Emma C ^a   Finlay, Andrew Y ^b  

^a SINGLETON HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884056335     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4160-6231-8.10022-4     Document Type: Chapter

References (99)

1. Harvell J.D., Maibach H.I. Percutaneous absorption and inflammation in aged skin: a review. J Am Acad Dermatol 1994, 31:1015-1021.
2. Plowden J., Renshaw-Hoelscher M., Engleman C., et al. Innate immunity in aging: impact on macrophage function. Aging Cell 2004, 3:161-167.
3. Waldorf D.S., Willkens R.F., Decker J.L. Impaired delayed hypersensitivity in an aging population. Association with antinuclear reactivity and rheumatoid factor. JAMA 1968, 203:831-834.
4. Kligman A.M., Koblenzer C. Demographics and psychological implications for the aging population. Dermatol Clin 1997, 15:549-553.
5. Oikarinen A. The aging of skin: chronoaging versus photoaging. Photodermatol Photoimmunol Photomed 1990, 7:3-4.
6. Kosmadaki M.G., Gilchrest B.A. The role of telomeres in skin aging/photoaging. Micron 2004, 35:155-159.
7. Nakamura K.I., Izumiyama-Shimomura N., Sawabe M., et al. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol 2002, 119:1014-1019.
8. Landau M. Exogenous factors in skin aging. Curr Probl Dermatol 2007, 35:1-13.
9. Leyden J.J. Clinical features of ageing skin. Br J Dermatol 1990, 122:1-3.
10. Kochevar I. Molecular and cellular effects of UV radiation relevant to chronic photodamage. Photodamage 1995, Blackwell Science, Cambridge, Mass. B.A. Gilchrest (Ed.).
11. Yaar M., Gilchrest B.A. Photoageing: mechanism, prevention and therapy. Br J Dermatol 2007, 157:874-887.
12. Saint Leger D., Francois A.M., Leveque J.L., et al. Age-associated changes in stratum corneum lipids and their relation to dryness. Dermatologica 1988, 177:159-164.
13. Grove G.L. Physiologic changes in older skin. Clin Geriatr Med 1989, 5:115-125.
14. Kadunce D.P., Burr R., Gress R., et al. Cigarette smoking: risk factor for premature facial wrinkling. Ann Intern Med 1991, 114:840-844.
15. Ernster V.L., Grady D., Miike R., et al. Facial wrinkling in men and women, by smoking status. Am J Public Health 1995, 85:78-82.
16. Yin L., Morita A., Tsuji T. Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies. Photodermatol Photoimmunol Photomed 2001, 17:178-183.
17. Yin L., Morita A., Tsuji T. Alterations of extracellular matrix induced by tobacco smoke extract. Arch Dermatol Res 2000, 292:188-194.
18. Tur E., Yosipovitch G., Oren-Vulfs S. Chronic and acute effects of cigarette smoking on skin blood flow. Angiology 1992, 43:328-335.
19. Robinson M.K. Population differences in skin structure and physiology and the susceptibility to irritant and allergic contact dermatitis: implications for skin safety testing and risk assessment. Contact Dermatitis 1999, 41:65-79.
20. Waller J.M., Maibach H.I. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol 2005, 11:221-235.
21. Waller J.M., Maibach H.I. Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure. Skin Res Technol 2006, 12:145-154.
22. Escoffier C., de Rigal J., Rochefort A., et al. Age-related mechanical properties of human skin: an in vivo study. J Invest Dermatol 1989, 93:353-357.
23. Ghadially R., Brown B.E., Sequeira-Martin S.M., et al. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 1995, 95:2281-2290.
24. Christophers E., Kligman A. Percutaneous absorption in aged skin. Advances in Biology of Skin 1965, Pergamon, Oxford. W. Montagna (Ed.).
25. Choi E.H., Man M.Q., Xu P., et al. Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol 2007, 127:2847-2856.
26. Hachem J.P., Crumrine D., Fluhr J., et al. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity//cohesion. J Invest Dermatol 2003, 121:345-353.
27. Kligman A.M. Perspectives and problems in cutaneous gerontology. J Invest Dermatol 1979, 73:39-46.
28. Branchet M.C., Boisnic S., Frances C., et al. Skin thickness changes in normal aging skin. Gerontology 1990, 36:28-35.
29. Lavker R.M. Structural alterations in exposed and unexposed aged skin. J Invest Dermatol 1979, 73:59-66.
30. Batisse D., Bazin R., Baldeweck T., et al. Influence of age on the wrinkling capacities of skin. Skin Res Technol 2002, 8:148-154.
31. Sandby-Moller J., Poulsen T., Wulf H.C. Epidermal thickness at different body sites: relationship to age, gender, pigmentation, blood content, skin type and smoking habits. Acta Derm Venereol 2003, 83:410-413.
32. Graham-Brown R.A.C. Old age. Rook's Textbook of Dermatology 2004, vol. 6. Blackwell Science, Oxford. T. Burns, S. Breathnach, N. Cox (Eds.).
33. Farage M.A., Miller K.W., Elsner P., et al. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol 2007, 26:343-357.
34. Cerimele D., Celleno L., Serri F. Physiological changes in ageing skin. Br J Dermatol 1990, 122(suppl 35):13-20.
35. Grove G.L., Kligman A.M. Age-associated changes in human epidermal cell renewal. J Gerontol 1983, 38:137-142.
36. Goodson W.H., Hunt T.K. Wound healing and aging. J Invest Dermatol 1979, 73:88-91.
37. Bosset S., Bonnet-Duquennoy M., Barre P., et al. Decreased expression of keratinocyte beta1 integrins in chronically sun-exposed skin in vivo. Br J Dermatol 2003, 148:770-778.
38. Fenske N.A., Lober C.W. Structural and functional changes of normal aging skin. J Am Acad Dermatol 1986, 15:571-585.
39. Baumann L. Skin ageing and its treatment. J Pathol 2007, 211:241-251.
40. Richard S., de Rigal J., de Lacharriere O., et al. Noninvasive measurement of the effect of lifetime exposure to the sun on the aged skin. Photodermatol Photoimmunol Photomed 1994, 10:164-169.
41. Makrantonaki E., Zouboulis C.C. William J Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 2007, 214:352-360.
42. Varani J., Spearman D., Perone P., et al. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol 2001, 158:931-942.
43. Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 1986, 4:433-446.
44. Braverman I.M., Fonferko E. Studies in cutaneous aging: I. The elastic fiber network. J Invest Dermatol 1982, 78:434-443.
45. Lavker R.M., Zheng P.S., Dong G. Aged skin: a study by light, transmission electron, and scanning electron microscopy. J Invest Dermatol 1987, 88:44s-51s.
46. Uitto J. Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin. Clin Geriatr Med 1989, 5:127-147.
47. Gniadecka M., Gniadecki R., Serup J., et al. Ultrasound structure and digital image analysis of the subepidermal low echogenic band in aged human skin: diurnal changes and interindividual variability. J Invest Dermatol 1994, 102:362-365.
48. Rittié L., Fisher G.J. UV-light-induced signal cascades and skin aging. Ageing Res Rev 2002, 1:705-720.
49. Shuster S., Black M.M., McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 1975, 93:639-643.
50. Lovell C.R., Smolenski K.A., Duance V.C., et al. Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol 1987, 117:419-428.
51. Contet-Audonneau J.L., Jeanmaire C., Pauly G. A histological study of human wrinkle structures: comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas. Br J Dermatol 1999, 140:1038-1047.
52. Ritz-Timme S., Laumeier I., Collins M.J. Aspartic acid racemization: evidence for marked longevity of elastin in human skin. Br J Dermatol 2003, 149:951-959.
53. Robert C., Lesty C., Robert A.M. Ageing of the skin: study of elastic fiber network modifications by computerized image analysis. Gerontology 1988, 34:291-296.
54. Bernstein E.F., Chen Y.Q., Tamai K., et al. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol 1994, 103:182-186.
55. Tsuji T., Hamada T. Age-related changes in human dermal elastic fibres. Br J Dermatol 1981, 105:57-63.
56. Gniadecka M., Nielsen O.F., Wessel S., et al. Water and protein structure in photoaged and chronically aged skin. J Invest Dermatol 1998, 111:1129-1133.
57. Bernstein E.F., Underhill C.B., Hahn P.J., et al. Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol 1996, 135:255-262.
58. Gniadecka M., Faurskov Nielsen O., Christensen D.H., et al. Structure of water, proteins, and lipids in intact human skin, hair, and nail. J Invest Dermatol 1998, 110:393-398.
59. Jacobson T.M., Yuksel K.U., Geesin J.C., et al. Effects of aging and xerosis on the amino acid composition of human skin. J Invest Dermatol 1990, 95:296-300.
60. Gilchrest B.A., Stoff J.S., Soter N.A. Chronologic aging alters the response to ultraviolet-induced inflammation in human skin. J Invest Dermatol 1982, 79:11-15.
61. Oberste-Lehn H. Aging. Effects of Aging on the Papillary Body of the Hair Follicles and on the Eccrine Sweat Glands 1965, vol. 6. Pergamon, Oxford. W. Montagna (Ed.).
62. Silver A., Montagna W., Karacan I. The effect of age on human eccrine sweating. Aging 1965, vol. 6. Pergamon, Oxford. W. Montagna (Ed.).
63. Rees J., Shuster S. Pubertal induction of sweat gland activity. Clin Sci (Lond) 1981, 60:689-692.
64. Hurley J., Shelley W. The Human Apocrine Sweat Gland in Health and Disease 1960, Charles C Thomas, Springfield, Ill.
65. Plewig G., Kligman A.M. Proliferative activity of the sebaceous glands of the aged. J Invest Dermatol 1978, 70:314-317.
66. Pochi P.E., Strauss J.S., Downing D.T. Age-related changes in sebaceous gland activity. J Invest Dermatol 1979, 73:108-111.
67. Gilchrest B.A. Aging. J Am Acad Dermatol 1984, 11:995-997.
68. Smith L. Histopathologic characteristics and ultrastructure of aging skin. Cutis 1989, 43:414-424.
69. Orentreich N., Markofsky J., Vogelman J.H. The effect of aging on the rate of linear nail growth. J Invest Dermatol 1979, 73:126-130.
70. Helmdach M., Thielitz A., Ropke E.M., et al. Age and sex variation in lipid composition of human fingernail plates. Skin Pharmacol Appl Skin Physiol 2000, 13:111-119.
71. Keogh E.V., Walsh R.J. Rate of greying of human hair. Nature 1965, 207:877-878.
72. Commo S., Gaillard O., Bernard B.A. Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath. Br J Dermatol 2004, 150:435-443.
73. Ellis J.A., Sinclair R., Harrap S.B. Androgenetic alopecia: pathogenesis and potential for therapy. Expert Rev Mol Med 2002, 4:1-11.
74. Whiting D.A. Male pattern hair loss: current understanding. Int J Dermatol 1998, 37:561-566.
75. Gilchrest B.A., Murphy G.F., Soter N.A. Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermis. J Invest Dermatol 1982, 79:85-88.
76. Thiers B.H., Maize J.C., Spicer S.S., et al. The effect of aging and chronic sun exposure on human Langerhans cell populations. J Invest Dermatol 1984, 82:223-226.
77. Bhushan M., Cumberbatch M., Dearman R.J., et al. Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Br J Dermatol 2002, 146:32-40.
78. Makinodan T. Immunodeficiencies of ageing. The Immune System: Functions and Therapy of Dysfunction 1980, Academic Press, New York. G. Doria, A. Eshkol (Eds.).
79. Ben-Yehuda A., Weksler M.E. Host resistance and the immune system. Clin Geriatr Med 1992, 8:701-711.
80. Grove G.L., Duncan S., Kligman A.M. Effect of ageing on the blistering of human skin with ammonium hydroxide. Br J Dermatol 1982, 107:393-400.
81. Winkelmann R. Advances in Biology of Skin 1965, vol. 6. Pergamon, Oxford. W. Montagna (Ed.).
82. Hall G., Phillips T.J. Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol 2005, 53:555-568.
83. Brincat M., Moniz C.J., Studd J.W., et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynaecol 1985, 92:256-259.
84. Affinito P., Palomba S., Sorrentino C., et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas 1999, 33:239-247.
85. Brincat M., Versi E., O'Dowd T., et al. Skin collagen changes in post-menopausal women receiving oestradiol gel. Maturitas 1987, 9:1-5.
86. Brincat M., Versi E., Moniz C.F., et al. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol 1987, 70:123-127.
87. Bolognia J.L., Braverman I.M., Rousseau M.E., et al. Skin changes in menopause. Maturitas 1989, 11:295-304.
88. Calleja-Agius J., Muscat-Baron Y., Brincat M.P. Skin ageing. Menopause Int 2007, 13:60-64.
89. Dunn L.B., Damesyn M., Moore A.A., et al. Does estrogen prevent skin aging? Results from the first national health and nutrition examination survey (NHANES I). Arch Dermatol 1997, 133:339-342.
90. Ashcroft G.S., Dodsworth J., van Boxtel E., et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997, 3:1209-1215.
91. Callens A., Vaillant L., Lecomte P., et al. Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology 1996, 193:289-294.
92. Sator P.G., Schmidt J.B., Sator M.O., et al. The influence of hormone replacement therapy on skin ageing: a pilot study. Maturitas 2001, 39:43-55.
93. Scharffetter-Kochanek K., Brenneisen P., Wenk J., et al. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 2000, 35:307-316.
94. Brincat M.P. Hormone replacement therapy and the skin. Maturitas 2000, 35:107-117.
95. Li G.Z., Eller M.S., Firoozabadi R., et al. Evidence that exposure of the telomere 3' overhang sequence induces senescence. Proc Natl Acad Sci USA 2003, 100:527-531.
96. Gilchrest B.A. A review of skin ageing and its medical therapy. Br J Dermatol 1996, 135:867-875.
97. Kligman A.M., Dogadkina D., Lavker R.M. Effects of topical tretinoin on non-sun-exposed protected skin of the elderly. J Am Acad Dermatol 1993, 29:25-33.
98. Kligman L.H. Effects of all-trans-retinoic acid on the dermis of hairless mice. J Am Acad Dermatol 1986, 15:779-785. 884-887.
99. Sies H., Stahl W. Nutritional protection against skin damage from sunlight. Ann Rev Nutr 2004, 24:173-200.