Vitamin D and Diabetes

Vitamin D

Volumn 2, Issue , 2005, Pages 1763-1778

  Mathieu, Chantal ^a   Gysemans, Conny ^a   Bouillon, Roger ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883908553     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012252687-9/50103-0     Document Type: Chapter

References (154)

1. 3 metabolism in kidney cell cultures: lack of a direct effect of estradiol. Am J Physiol 1981, 240:E119-E124.
2. Condamine L, Vztovsnik F, Friedlander G, Menaa C, Garabedian M Local action of phosphate depletion and insulin-like growth factor 1 on in vitro production of 1,25-dihydroxyvitamin D by cultured mammalian kidney cells. J Clin Invest 1994, 94:1673-1679.
3. Nyomba BL, Verhaeghe J, Thomasset M, Lissens W, Bouillon R Bone mineral homeostasis in spontaneously diabetic BB rats. I. Abnormal vitamin D metabolism and impaired active intestinal calcium absorption. Endocrinology 1989, 124:565-572.
4. Verhaeghe J, Van Herck E, Visser WJ, Suiker AMH, Thomasset M, Einhorn TA, Faierman E, Bouillon R Bone and mineral metabolism in BB rats with long-term diabetes. Diabetes 1990, 39:477-482.
5. Nyomba BL, Bouillon R, Lissens W, Van Baelen H, De Moor P 1,25-dihydroxyvitamin-D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats. Endocrinology 1985, 116:2483-2488.
6. Hough S, Russell JE, Teitelbaum SL, Avioli LV Calcium homeostasis in chronic streptozotocin-induced diabetes mellitus in the rat. Am J Physiol 1982, 242:E451-E456.
7. Schneider LE, Schedl HP, McCain T, Haussler MR Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat. Science 1977, 196:1452-1454.
8. Storm TL, Sorensen OH, Lund B, Christiansen JS, Andersen AR, Lumholtz IB, Parving HH Vitamin D metabolism in insulin-dependent diabetes mellitus. Metab BoneDis Relat Res 1983, 5:107-110.
9. Nyomba BL, Bouillon R, Bidingij M, Kandjing K, De Moor P Vitamin D metabolites and their binding protein in adult diabetic-patients. Diabetes 1986, 35:911-915.
10. Rodland O, Markesta T, Aksnes L, Aarskog D Plasma concentrations of vitamin D metabolites during puberty of diabetic children. Diabetology 1985, 28:663-666.
11. Verrotti A, Basciani F, Carle F, Morgese G, Chiarelli F Calcium metabolism in adolescents and young adults with type 1 diabetes mellitus without and with persistent microalbuminuria. J Endocrinol Invest 1999, 22:198-202.
12. Auwerx J, Dequeker J, Bouillon R, Geusens P, Nijs J Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus. Diabetes 1988, 37:8-12.
13. 3 in diabetic rats. Am J Physiol 1993, 265:E215-E223.
14. Schneider LE, Schedl HP Diabetes and intestinal calcium absorption in the rat. Am J Physiol 1972, 223:1319-1323.
15. Schneider LE, Wilson HD, Schedl HP Effects of alloxan diabetes on duodenal calcium-binding protein in the rat. Am J Physiol 1974, 227:832-838.
16. Stone LA, Weaver VM, Bruns ME, Christakos S, Welsh J Vitamin D receptors and compensatory tissue growth in spontaneously diabetic BB rats. Ann Nutr Metab 1991, 35:196-202.
17. Bouillon R, Verhaeghe J, Bex M, Suiker A, Visser W Diabetic boen disease. Diabetes 1991, 1271-1274. Elsevier Science, Amsterdam Publishers. H. Rifkin, J.A. Colwell, S.I. Taylor (Eds.).
18. Verhaeghe J, Suiker AMH, Visser WJ, Van Herck E, Van Bree R, Bouillon R The effects of systemic insulin, insulin-like growth factor-I and growth hormone on bone growth and tumover in spontaneously diabetic BB rats. J Endocrinol 1992, 134:485-492.
19. Verhaeghe J, Bouillon R Actions of insulin and the IGFs on bone. NIPS 1994, 9:20-22.
20. Binz K, Schmid C, Bouillon R, Froesch ER, Jürgersen K, Hunziker EB Interactions of insulin-like growth factor I with dexamethasone on trabecular bone density and mineral metabolism in rats. Eur J Endocrinol 1994, 130:387-393.
21. Verhaeghe J, van Bree R, Van Herck E, Thomas H, Skottner A, Dequeker J, Mosekilde L, Einhorn TA, Bouillon R Effects of recombinant human growth hormone and insulin-like growth factor-I, with or without 17 beta-estradiol, on bone and mineral homeostasis of aged ovariectomized rats. J Bone Miner Res 1996, 11:1723-1735.
22. De Fronzo RA, Bonadonna RC, Ferrannini E Pathogenesis of NIDDM. Diabetes Care 1992, 15:318-368.
23. Taylor SI, Accili D, Imai Y Insulin resistance or insulin deficiency-Which is the primary cause of NIDDM?. Diabetes 1994, 43:735-740.
24. Castano L, Eisenbarth GS Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 1990, 8:647-679.
25. 3 as an immunomodulator. Trends Mol Med 2002, 8:174-179.
26. 3 in chick kidney and pancreas. Biochem Biophys Res Commun 1979, 89:56-63.
27. 3 in the immune system and skin creates new therapeutic possibilities for vitamin D analogs. Eur J Endocrinol 1995, 133:7-16.
28. 3. Current Opinion in Nephrology and Hypertension 1995, 4:313-318.
29. Norman AW, Frankel BJ, Heldt AM, Grodsky GM Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209:823-825.
30. 3 and pancreatic β-cell function. Vitamin D receptors, gene expression, and insulin secretion. Endocrinology 1994, 134:1602-1610.
31. 3 of insulin secretion and glucose tolerance in the vitamin D-deficient rat. Endocrinology 1987, 120:1490-1497.
32. 2+ transport). Endocrinology 1990, 127:2475-2480.
33. Norman AW Editorial: The vitamin D endocrine system: Identification of another piece of the puzzle. Endocrinology 1994, 134:A1601-C1601.
34. 3 evokes oscillations of intracellular calcium in a pancreatic β-cell line. Endocrinology 1995, 136:2852-2861.
35. 3. Mol Cell Endocrinol 2002, 197:1-13.
36. Roth J, Bonner-Weir S, Norman AW, Orci L Immunocytochemistry of vitamin D-dependent calcium-binding protein in chick pancreas: exclusive localization in B-cells. Endocrinology 1982, 110:2216-2218.
37. Chertow BS, Sivitz WI, Baranetsky NG, Clark SA, Waite A, DeLuca HF Cellular mechanisms of insulin release: The effects of vitamin D deficiency and repletion on rat insulin secretion. Endocrinology 1983, 113:1511-1518.
38. Nyomba BL, Bouillon R, De Moor P Influence of vitamin D status on insulin secretion and glucose tolerance in the rabbit. Endocrinology 1984, 115:191-197.
39. Kadowaki S, Norman AW Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. J Clin Invest 1984, 73:759-766.
40. 3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology 1986, 119:84-90.
41. Gedik O, Akalin S Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986, 29:142-145.
42. 3 on the pancreatic secretion of insulin and somatostatin. Acta Endocrinol 1984, 105:528-533.
43. 3 on insulin secretion: direct or mediated?. Endocrinology 1986, 118:1971-1976.
44. Isaia G, Giorgino R, Adami S High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care 2001, 24:1496.
45. Beaulieu C, Kestekian R, Havrankova J, Gascon-Barré M Calcium is essential in normalizing intolerance to glucose that accompanies vitamin D depletion in vivo. Diabetes 1993, 42:35-43.
46. Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 2003, 17:509-511.
47. Mathieu C, Van Etten E, Gysemans C, Decallonne B, Kato S, Laureys J, Depovere J, Valckx D, Verstuyf A, Bouillon R In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. J Bone Miner Res. 2001, 16:2057-2065.
48. Zella JB, DeLuca HF Vitamin D and autoimmune diabetes. J Cell Biochem 2003, 88:216-222.
49. 3-deprived rats. Am J Physiol 1990, 258:E643-E648.
50. 3-deficient rats. Steroids 1993, 58:335-341.
51. 3 administration. Endocrinology 1985, 117:1765-1771.
52. 3 on insulin production by neonatal rat islets. Biochem Biophys Res Commun 1989, 164:413-418.
53. 3 reduces MHC antigen expression on pancreatic beta-cells in vitro. Transplant Proc 1997, 29:2156-2157.
54. Kumar S, Davies M, Zakaria Y, Mawer EB, Gordon C, Olukoga AO, Boulton AJM Improvement in glucose tolerance and beta-cell function in a patient with vitamin D deficiency during treatment with vitamin D. Postgrad Med J 1994, 70:440-443.
55. Gedik O, Akalin S Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986, 29:142-145.
56. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995, 38:1239-1245.
57. 3. Nephron 1994, 68:41-47.
58. Orwoll E, Riddle M, Prince M Effects of vitamin D on insulin and glucagon secretion in noninsulin-dependent diabetes mellitus. Am J Clin Nutr 1994, 59:1083-1087.
59. Orwoll E, Riddle M, Prince M Effects on vitamin D on insulin and glucagon secretion in noninsulin-dependent diabetes mellitus. Am J Clin Nutr 1994, 59:1083-1087.
60. 3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin pract. 2003, 57:258-261.
61. Taylor AV, Wise PH Vitamin D replacement in Asians with diabetes may increase insulin resistnace. Postgrad Med J 1998, 74:365-366.
62. Variation and trends in incidence of childhood diabetes in Europe. Lancet 2000, 355:873-876. EURODIAB ACE Study Group.
63. Jantti V, Muntoni S, Stabilini M, Stabilini L, Muntoni S, Tuomilehto J Comparison of the seasonal pattern in the clinical onset of IDDM in finland and Sardinia. Diabetes Care 1998, 21:1101-1109.
64. Stene CL, Ulriksen J, Magnus P, Goner G Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia 2000, 43:1093-1098.
65. Hypponen B, Laara E, Reumanen A, Jarvelin MR, Virtanen SM Intake of vitamin D and risk of type 1 dibetes: a birthcohort study. Lancet 2001, 358:1500-1503.
66. Mathieu C, van Etten E, Gysemans C, Decallonne B, Bouillon R Seasonality of birth in patients with type 1 diabetes. Lancet 2002, 359:1248.
67. 3 and the analogs MC903 and KH1060 on interleukin-1 beta-induced inhibition of rat pancreatic islet beta-cell function in vitro. Immunol Lett 1994, 41:73-77.
68. Mauricio D, Andersen HU, Karlsen AE, Mandrup-Poulsen T, Nerup J Effect of steroidal hormones on interleukin-1 action on rat islets. Diabetologia 1995, 38S:A80.
69. 3 on cytokine-treated human pancreatic islets. J Endocrinol 2001, 169:161-168.
70. 3 protects RINm5F and human islet cells against cytokine-induced apoptosis implication of the antiapoptotic protein A20. Endocrinology 2002, 143:4809-4819.
71. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y Breeding of a nonobese, diabetic strain of mice. Exp Anim 1980, 29:1-13.
72. 3 prevents insulitis in NOD mice. Diabetes 1992, 41:1491-1495.
73. 3. Diabetologia 1994, 37:552-558.
74. 3 enhances the generation of nonspecific suppressor cells while inhibiting the induction of cytotoxic cells in a human MLR. Cell Immunol 1992, 140:400-409.
75. Adorini L, Gregori S, Harrison LC Understanding autoimmune diabetes: insights from mouse models. Trends Mol Med 2002, 8:31-38.
76. Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002, 51:1367-1374.
77. Harada M, Makino S Promotion of spontaneous diabetes in nonobese diabetes-prone mice by cyclophosphamide. Diabetologia 1984, 27:604-606.
78. Yasunami R, Bach JF Antisuppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur J Immunol 1988, 18:481-484.
79. Mitsuoka A, Baba M, Morikawa S Enhancement of delayed hypersensitivity by depletion of suppressor T-cells with cyclophosphamide in mice. Nature 1976, 262:77-78.
80. Qin HY, Sadelain M, Hitchon C, Lauzon J, Singh B Complete Freund's adjuvant-induced T-cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J Immunol 1993, 150:2072-2080.
81. Lakey J, Singh B, Warnock G, Elliott J, Rajotte R Long-term survival of syngeneic islet grafts in BCG-treated diabetic NOD mice can be reversed by cyclophosphamide. Transplantation 1995, 59:1751-1753.
82. Shintani S, Satoh J, Seino H, Goto Y, Toyota T Mechanism of action of a streptococcal preparation (OK-432) in prevention of autoimmune diabetes in NOD mice. J Immunol 1990, 144:136-141.
83. 3 restores sensitivity to cyclophosphamide-induced apoptosis in nonobese diabetic (NOD) mice and protects against diabetes. Clin Exp Immunol 1998, 112:181-187.
84. 3 induces an autoantigenspecific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes 2000, 49:1301-1307.
85. Adorini L Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T-cells inhibiting autoimmune diabetes. Ann NY Acad Sci 2003, 987:258-261.
86. van Halteren AG, van Etten E, de Jong EC, Bouillon R, Reep BO, Mathieu C Redirection of human autoreactive T-cells upon interaction with dendritic, cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3). Diabetes 2002, 51:2119-2125.
87. 3 restores defect. Diabetes 1998, 47:1033-1037.
88. Kolb H, Kröncke KD IDDM-Lessons from the low-dose streptozocin model in mice. Diab Rev 1993, 1:116-126.
89. 3 against the development of diabetes induced by multiple low-dose streptozotocin injection in CD-1 mice. Metabolism 1992, 41:631-635.
90. Guttmann RD, Colle E, Michel F, Seemayer T Spontaneous diabetes mellitus syndrome in the rat: T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J Immunol 1983, 130:1732-1735.
91. Georgiou HM, Lagarde AC, Bellgrau D T-cell dysfunction in the diabetes-prone BB rat. J Exp Med 1988, 167:132-147.
92. Elder ME, Maclaren NK Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J Immunol 1983, 130:1723-1731.
93. Mathieu C, Casteels K, Bouillon R Vitamin D and diabetes. Vitamin D 1997, 1183-1196. Academic press, San Diego. D. Feldman, F. Glorieux, J. Pike (Eds.).
94. Bikle DD Clinical counterpoint: Vitamin D: New actions, new analogs, new therapeutic potential. Endocrine Reviews 1992, 13:765-784.
95. Bouillon RK, Allewaert K, Xiang DZ, Tan BK, Van Baelen H Vitamin D analogs with low affinity for the vitamin D-binding protein: Enhanced in vitro and decreased in vivo activity. J Bone Mineral Res 1991, 6:1051-1057.
96. Bouillon R, Okamura WH, Norman AW Structurefunction relationships in the vitamin D endocrine system. End Rev 1995, 16:200-257.
97. Verstuyf A, Verlinden L, van Etten E, Shi L, Wu Y, D'Halleweyn C, Van Haver D, Zhu GH, Chen YJ, Zhou X, Haussler MR, De Clercq P, Vandewalle M, Van Baelen H, Mathieu C, Bouillon R Biological activity of CD-ring modified 1alpha,25-dihydroxyvitamin D analogs: C-ring and five-membered D-ring analogs. J Bone Miner Res 2000, 15:237-252.
98. Verstuyf A, Segaert S, Verlinden L, Bouillon R, Mathieu C Recent developments in the use of vitamin D analogs. Expert Opin Investig Drugs 2000, 9:443-455.
99. 3. Clin Exp Immunol 1993, 94:412-417.
100. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J Clin Invest 1991, 87:1103-1107.
101. 3 inhibits the passive transfer of cellular immunity by a myelin basic protein-specific T-cell clone. J Bone Mineral Res 1992, 7:171-177.
102. 3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990, 54:53-63.
103. 3 prolongs rat cardiac allograft survival. Vitamin D: Molecular Cellular, and Clinical Endocrinology 1988, 334-335. W. de Gruyter, Berlin, New York. K. Schaeffer, A.W. Norman, H.G. Grigoleit, D.V. Herrath (Eds.).
104. Latini S, Binderup L KH1060: A new vitamin D analog with potent effects on cell-mediated immune responses in vitro. Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application 1991, 516-519. W. de Gruyter, Berlin, New York. A.W. Norman, R. Bouillon, M. Thomasset (Eds.).
105. 3, KH1060. Endocrinology 1995, 136:866-872.
106. Mori Y, Suko M, Okudaira H, Matsuba I, Tsuruoka A, Sasaki A, Yokoyama H, Tanase T, Shida T, Nishumira M, Terada E, Ikeda Y Preventive effects of cyclosporine on diabetes in NOD mice. Diabetologia 1986, 29:244-247.
107. Weir MR, Fink JC Risk for post-transplant diabetes mellitus with current immunosuppressive medications. Am J Kidney Dis 1999, 34:1-13.
108. Bach JF Predictive medicine in autoimmune diseases: from the identification of genetic predisposition and environmental influence to precocious immunotherapy. Clin Immunol Immunopathol 1994, 72:156-161.
109. 3 in combination with cyclosporin A. Transplant Proc 1996, 28:3095.
110. 3 as dose-reducing agents for classical immunosuppressants. Transplantation 2000, 69:1932-1942.
111. Weringer EJ, Like AA Diabetes mellitus in the BB/W rat-Insulitis in pancreatic islet grafts after transplantation in diabetic recipients. Am J Pathol 1986, 125:107-112.
112. Mandel TE, Koulmanda M, Loudovaris T, Bacelj A Islet grafts in NOD mice: A comparison of Iso-, Allo-, and pig xenografts. Transplant Proc 1989, 21:3813-3814.
113. Lafferty KJ Islet transplantation as a therapy for type I diabetes mellitus. Diab Nutr Metab 1989, 2:323-332.
114. Bartlett ST, Killewich LA Recurrent diabetes in pancreas transplants in the BB rat: Evidence for a defect extrinsic to the beta cell. Transplant Proc 1991, 23:689-690.
115. Pipeleers D, Pipeleers-Marchal M, Markholst H, Hoorens A, Klöppel G Transplantation of purified islet cells in diabetic BB rats. Diabetologia 1991, 34:390-396.
116. Woehrle M, Pullmann J, Bretzel RG, Federlin K Recurrence of diabetes after islet transplantation in the BB rat. Transplant Proc 1992, 24:999.
117. Woehrle M, Pullmann J, Bretzel RG, Federlin K Prevention of recurrent autoimmune diabetes in the BB rat by islet transplantation under the renal kidney capsule. Transplantation 1992, 53:1099-1102.
118. Lacy PE Status of islet cell transplantation. Diab Rev 1993, 1:76-92.
119. Ricordi C, Tzakis AG, Carroll PB, Zeng Y, Rodriguez Rilo HL, Alejandro R, Shapiro R, Fung JJ, Demetris AJ, Mintz DH, Startzl TE Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation 1992, 53:407-414.
120. Sharp DW, Lacy PE, Santiago JV, McCullough CS, Weide LG, Boyle PJ, Falqui L, Marchetti P, Ricordi C, Gingerich RL, Jaffe AS, Cryer PE, Hanto DW, Anderson CB, Wayne Flye M Results of our first nine intraportal islet allografts in type I, insulin-dependent diabetic patients. Transplantation 1991, 51:76-85.
121. Mathieu C, Bouillon R, Laureys J, Waer M Prevention of autoimmune destruction of transplanted islets in spontaneously diabetic NOD mice by KH1060, a 20-epi analog of vitamin D-Synergy with cyclosporin A. Transpl Proc 1994, 26:3128-3129.
122. Katz I, Epstein S Post-transplantation bone disease. J Bone Mineral Res 1992, 7:123-126.
123. 3 and mycophenolate mofetil, treatment mediate transplantation tolerance. J Immunol 2001, 167:1945-1953.
124. 3. Clin Exp Immunol 2002, 128:213-220.
125. McDermott MF, Ramachandran A, Ogunkolade BW, Aganna E, Curtis D, Boucher BJ, Snehalatha C, Hitman GA Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia 1997, 40:971-975.
126. Chang TJ, Lei HH, Yeh JI, Chiu KC, Lee KC, Chen MC, Tai TY, Chuang LM Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population. Clin Endocrinol 2000, 52:575-580.
127. Pani MA, Knapp M, Donner H, Braun J, Baur MP, Usadel KH, Badenhoop K Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans. Diabetes 2000, 49:504-507.
128. Yokota I, Satomura S, Kitamura S, Taki Y, Naito E, Ito M, Nisisho K, Kuroda Y Association between vitamin D receptor genotype and age of onset in juvenile Japanese patients with type 1 diabetes. Diabetes Care 2002, 25:1244.
129. Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, North BV, Mannan N, McDermott MF, DeLuca HF, Hitman GA Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 2002, 51:2294-2300.
130. Ban Y, Taniyama M, Yanagawa T, Yamada S, Maruyama T, Kasuga A, Bay Y Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population. BMC Med Genet 2001, 2:7.
131. Hitman GA, Mannan N, McDermott MF, Aganna E, Ogunkolade BW, Hales CN, Boucher BJ Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. Diabetes 1998, 47:688-690.
132. Oh JY, Barrett-Connor E Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism 2002, 51:356-359.
133. Ortlepp JR, Metrikat J, Albrecht M, von Korff A, Hanrath P, Hoffmann R The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabet Med 2003, 20:451.
134. 3 in combination with a short induction course of cyclosporine A. Endocrinology 1998, 139:95-102.
135. 3 analog and cyclosporin A. Transplantation 1998, 65:1-8.
136. 3 analog, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc 2001, 33:2365.
137. 3. Cell Immunol 1989, 121:290-297.
138. 3 potentiates the in vitro inhibitory effects of cyclosporine A on T-cells from rheumatoid arthritis patients. Arthritis Rheum 1989, 32:31-36.
139. 3 in vitro and in vivo. J Neuroimmunol 1997, 79:138-147.
140. 3 and corticosteroids on TH1, but not TH2, responses. J Allergy Clin Immunol 2000, 106:981-985.
141. 3 and glucocorticoid pathways. Biochem Biophys Res Commun 2002, 297:645-652.
142. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylomicz CM, O'Garra A In vitro generation of interleukin 10-producing regulatory CD4+T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603-616.
143. 3. J Neuroimmunol 1995, 61:151-160.
144. Lillevang ST, Rosenkvist J, Andersen CB, Larsen S, Kemp E, Kristensen T Single and combined effects of the vitamin D analog KH1060 and cyclosporine A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol 1992, 88:301-306.
145. 2-induced autoimmunity in the brown Norway rats. Nephrol Dial Transplant 1995, 10:2020-2026.
146. Boissier MC, Chiocchia G, Fournier C Combination of cyclosporine A and calcitriol in the treatment of adjuvant arthritis. J Rheumatol 1992, 19:754-757.
147. 3 in combination with cyclosporine A: mechanism of action involves an immune shift from Th1 to Th2. Transplant Proc 1998, 30:541.
148. 3 shows strong and additive immunoregulatory effects with cycloposrine A in rat renal allotransplants. Kidney Int 2002, 61:288-296.
149. Kallio E, Hayry P, Pakkala S MC1288, a vitamin D analog, reuces short- and long-term renal allograft, rejection in the rat. Transplant Proc 1996, 28:3113.
150. Redaelli CA, Wagner M, Tien YH, Mazzucchelli L, Stahel PF, Schilling MK, Dufour JF 1alpha,25-dihydroxycholecalciferol reduces rejection and improves survival in rat liver allografts. Hepatology 2001, 34:926-934.
151. Pakkala I, Taskinen E, Pakkala S, Raisanen-Sokolowski A MC1288, a vitamin D analog, prevents acute graft-versus-host disease in rat bone marrow transplantation. Bone Marrow Transplant 2001, 27:863-867.
152. Raisanen-Sokolowski AK, Pakkala IS, Samila SP, Binderup L, Hayry PJ, Pakkala ST A vitamin D analog, MC1288, inhibits adventitial inflammation and suppresses intimal, lesions in rat aortic allografts. Transplanatation 1997, 63:936-941.
153. Johnsson C, Binderup L, Tufveson G The effects of combined treatment with the novel vitamin D analog MC1288 and cyclosporine A on cardiac allograft survival. Transplant Immunol 1995, 3:245-250.
154. 3 analogs: immunosuppressive effects on skin allograft survival. Transplant Proc 1995, 27:450.