A transcriptomic network identified in uninfected macrophages responding to inflammation controls intracellular pathogen survival

Cell Host and Microbe

Volumn 14, Issue 3, 2013, Pages 357-368

  Beattie, Lynette ^a   D'El Rei Hermida, Micely ^a,b   Moore, John W J ^a,c   Maroof, Asher ^a   Brown, Najmeeyah ^a   Lagos, Dimitris ^a   Kaye, Paul M ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOID X RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EUKARYOTE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; KUPFFER CELL; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIASIS; MACROPHAGE; MOUSE; NONHUMAN; PARASITE; PRIORITY JOURNAL; SURVIVAL; TRANSCRIPTOMICS;

ANIMALIA; LEISHMANIA DONOVANI; MUS;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE REGULATORY NETWORKS; HOST-PATHOGEN INTERACTIONS; INFLAMMATION; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LIVER; MACROPHAGES; MICE; TRANSCRIPTOME;

EID: 84883896199     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2013.08.004     Document Type: Article

References (47)

1. T. Aebischer, C.L. Bennett, M. Pelizzola, C. Vizzardelli, N. Pavelka, M. Urbano, M. Capozzoli, A. Luchini, T. Ilg, and F. Granucci A critical role for lipophosphoglycan in proinflammatory responses of dendritic cells to Leishmania mexicana Eur. J. Immunol. 35 2005 476 486
2. J. Alvar, I.D. Vélez, C. Bern, M. Herrero, P. Desjeux, J. Cano, J. Jannin, M. den Boer WHO Leishmaniasis Control Team Leishmaniasis worldwide and global estimates of its incidence PLoS ONE 7 2012 e35671
3. L. Beattie, A. Peltan, A. Maroof, A. Kirby, N. Brown, M. Coles, D.F. Smith, and P.M. Kaye Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells PLoS Pathog. 6 2010 e1000805
4. L. Beattie, R. Phillips, N. Brown, B.M. Owens, N. Chauhan, J.E. Dalton, and P.M. Kaye Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver Infect. Immun. 79 2011 1057 1066
5. K.W. Bruhn, C. Marathe, A.C. Maretti-Mira, H. Nguyen, J. Haskell, T.A. Tran, V. Vanchinathan, U. Gaur, M.E. Wilson, P. Tontonoz, and N. Craft LXR deficiency confers increased protection against visceral Leishmania infection in mice PLoS Negl. Trop. Dis. 4 2010 e886
6. S. Buates, and G. Matlashewski General suppression of macrophage gene expression during Leishmania donovani infection J. Immunol. 166 2001 3416 3422
7. D. Chaussabel, R.T. Semnani, M.A. McDowell, D. Sacks, A. Sher, and T.B. Nutman Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites Blood 102 2003 672 681
8. B.E. Clausen, C. Burkhardt, W. Reith, R. Renkawitz, and I. Förster Conditional gene targeting in macrophages and granulocytes using LysMcre mice Transgenic Res. 8 1999 265 277
9. P.E. Cramer, J.R. Cirrito, D.W. Wesson, C.Y. Lee, J.C. Karlo, A.E. Zinn, B.T. Casali, J.L. Restivo, W.D. Goebel, and M.J. James ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models Science 335 2012 1503 1506
10. M. Duvic, K. Hymes, P. Heald, D. Breneman, A.G. Martin, P. Myskowski, C. Crowley, R.C. Yocum Bexarotene Worldwide Study Group Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results J. Clin. Oncol. 19 2001 2456 2471
11. M. Ebisawa, H. Umemiya, K. Ohta, H. Fukasawa, E. Kawachi, G. Christoffel, H. Gronemeyer, M. Tsuji, Y. Hashimoto, K. Shudo, and H. Kagechika Retinoid X receptor-antagonistic diazepinylbenzoic acids Chem. Pharm. Bull. (Tokyo) 47 1999 1778 1786
12. J. Ehrchen, L. Helming, G. Varga, B. Pasche, K. Loser, M. Gunzer, C. Sunderkötter, C. Sorg, J. Roth, and A. Lengeling Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major FASEB J. 21 2007 3208 3218
13. N.A. Ettinger, and M.E. Wilson Macrophage and T-cell gene expression in a model of early infection with the protozoan Leishmania chagasi PLoS Negl. Trop. Dis. 2 2008 e252
14. M.D. Galvan, D.B. Foreman, E. Zeng, J.C. Tan, and S.S. Bohlson Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells J. Immunol. 188 2012 3716 3723
15. E. Giraud, H. Lecoeur, G. Soubigou, J.Y. Coppée, G. Milon, E. Prina, and T. Lang Distinct transcriptional signatures of bone marrow-derived C57BL/6 and DBA/2 dendritic leucocytes hosting live Leishmania amazonensis amastigotes PLoS Negl. Trop. Dis. 6 2012 e1980
16. P.M. Gorak, C.R. Engwerda, and P.M. Kaye Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection Eur. J. Immunol. 28 1998 687 695
17. K.Y. Helmy, K.J. Katschke Jr., N.N. Gorgani, N.M. Kljavin, J.M. Elliott, L. Diehl, S.J. Scales, N. Ghilardi, and M. van Lookeren Campagne CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens Cell 124 2006 915 927
18. E. Hoffmann, S. Marion, B.B. Mishra, M. John, R. Kratzke, S.F. Ahmad, D. Holzer, P.K. Anand, D.G. Weiss, G. Griffiths, and S.A. Kuznetsov Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis Eur. J. Cell Biol. 89 2010 693 704
19. W. Huang, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat. Protoc. 4 2009 44 57
20. R.G. Jenner, and R.A. Young Insights into host responses against pathogens from transcriptional profiling Nat. Rev. Microbiol. 3 2005 281 294
21. F.R. Khuri, J.R. Rigas, R.A. Figlin, R.J. Gralla, D.M. Shin, R. Munden, N. Fox, M.R. Huyghe, Y. Kean, S.D. Reich, and W.K. Hong Multi-institutional phase I/II trial of oral bexarotene in combination with cisplatin and vinorelbine in previously untreated patients with advanced non-small-cell lung cancer J. Clin. Oncol. 19 2001 2626 2637
22. H. Lecoeur, E. de La Llave, J. Osorio Y Fortéa, S. Goyard, H. Kiefer-Biasizzo, A.M. Balazuc, G. Milon, E. Prina, and T. Lang Sorting of Leishmania-bearing dendritic cells reveals subtle parasite-induced modulation of host-cell gene expression Microbes Infect. 12 2010 46 54
23. W.Y. Lee, T.J. Moriarty, C.H. Wong, H. Zhou, R.M. Strieter, N. van Rooijen, G. Chaconas, and P. Kubes An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells Nat. Immunol. 11 2010 295 302
24. P. Lei, A. Baysa, H.I. Nebb, G. Valen, T. Skomedal, J.B. Osnes, Z. Yang, and F. Haugen Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury Basic Res. Cardiol. 108 2013 323
25. J.D. MacMicking Interferon-inducible effector mechanisms in cell-autonomous immunity Nat. Rev. Immunol. 12 2012 367 382
26. M.J. McConville, and T. Naderer Metabolic pathways required for the intracellular survival of Leishmania Annu. Rev. Microbiol. 65 2011 543 561
27. H.W. Murray Tissue granuloma structure-function in experimental visceral leishmaniasis Int. J. Exp. Pathol. 82 2001 249 267
28. M.D. Muzumdar, B. Tasic, K. Miyamichi, L. Li, and L. Luo A global double-fluorescent Cre reporter mouse Genesis 45 2007 593 605
29. L. Nagy, A. Szanto, I. Szatmari, and L. Széles Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response Physiol. Rev. 92 2012 739 789
30. M. Naito, G. Hasegawa, Y. Ebe, and T. Yamamoto Differentiation and function of Kupffer cells Med. Electron Microsc. 37 2004 16 28
31. S. Oghumu, C.M. Lezama-Dávila, A.P. Isaac-Márquez, and A.R. Satoskar Role of chemokines in regulation of immunity against leishmaniasis Exp. Parasitol. 126 2010 389 396
32. K. Oikonomopoulou, D. Ricklin, P.A. Ward, and J.D. Lambris Interactions between coagulation and complement - their role in inflammation Semin. Immunopathol. 34 2012 151 165
33. J. Osorio y Fortéa, E. de La Llave, B. Regnault, J.Y. Coppée, G. Milon, T. Lang, and E. Prina Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes BMC Genomics 10 2009 119
34. Y. Pawitan, S. Michiels, S. Koscielny, A. Gusnanto, and A. Ploner False discovery rate, sensitivity and sample size for microarray studies Bioinformatics 21 2005 3017 3024
35. Y. Pawitan, K.R. Murthy, S. Michiels, and A. Ploner Bias in the estimation of false discovery rate in microarray studies Bioinformatics 21 2005 3865 3872
36. + T cell immunity Nat. Immunol. 14 2013 271 280
37. D. Ricklin, G. Hajishengallis, K. Yang, and J.D. Lambris Complement: a key system for immune surveillance and homeostasis Nat. Immunol. 11 2010 785 797
38. N.E. Rodriguez, H.K. Chang, and M.E. Wilson Novel program of macrophage gene expression induced by phagocytosis of Leishmania chagasi Infect. Immun. 72 2004 2111 2122
39. C.D. Sadik, and A.D. Luster Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation J. Leukoc. Biol. 91 2012 207 215
40. Q. Shen, G.W. Cline, G.I. Shulman, M.D. Leibowitz, and P.J. Davies Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice J. Biol. Chem. 279 2004 19721 19731
41. V.F. Shih, J. Davis-Turak, M. Macal, J.Q. Huang, J. Ponomarenko, J.D. Kearns, T. Yu, R. Fagerlund, M. Asagiri, E.I. Zuniga, and A. Hoffmann Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways Nat. Immunol. 13 2012 1162 1170
42. S.C. Smelt, C.R. Engwerda, M. McCrossen, and P.M. Kaye Destruction of follicular dendritic cells during chronic visceral leishmaniasis J. Immunol. 158 1997 3813 3821
43. O. Soehnlein, and L. Lindbom Phagocyte partnership during the onset and resolution of inflammation Nat. Rev. Immunol. 10 2010 427 439
44. A.F. Suffredini, G. Fantuzzi, R. Badolato, J.J. Oppenheim, and N.P. O'Grady New insights into the biology of the acute phase response J. Clin. Immunol. 19 1999 203 214
45. J.P. Whitcomb, M. Deagostino, M. Ballentine, J. Fu, M. Tenniswood, J. Welsh, M. Cantorna, and M.A. McDowell The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection J. Parasitol. Res. 2012 2012 134645
46. T. Yamauchi, H. Waki, J. Kamon, K. Murakami, K. Motojima, K. Komeda, H. Miki, N. Kubota, Y. Terauchi, and A. Tsuchida Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes J. Clin. Invest. 108 2001 1001 1013
47. S. Zhang, C.C. Kim, S. Batra, J.H. McKerrow, and P. Loke Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines PLoS Negl. Trop. Dis. 4 2010 e648