Effect of type and ratio of solubilising polymer on characteristics of hot-melt extruded orodispersible films

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 138-147

  Low, Ariana Qiao Jun ^a,b   Parmentier, Johannes ^a,c   Khong, Yuet Mei ^a   Chai, Cherry Chang Er ^a,d   Tun, Thin Yu ^a   Berania, Jacqueline E ^a   Liu, Xueming ^a   Gokhale, Rajeev ^a   Chan, Sui Yung ^b  

^a ABBVIE INC   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NONE   (Germany)

^d NONE   (Singapore)

Author keywords

Copovidone; Hot melt extrusion; Mechanical properties; Orodispersible film; Solubilising polymer ratio; Soluplus

Indexed keywords

CHLORPHENIRAMINE; HYDROXYPROPYLCELLULOSE; INDOMETACIN; POLYMER;

ARTICLE; DRUG RELEASE; DRUG SOLUBILITY; FACTORIAL DESIGN; FILM; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; RIGIDITY; SURFACE PROPERTY; TENSILE STRENGTH; THERMAL ANALYSIS; THICKNESS; WATER CONTENT; X RAY DIFFRACTION;

CHL; CHLORPHENIRAMINE; COPOVIDONE; HME; HOT-MELT EXTRUSION; HPC; HYDROXYPROPYL CELLULOSE; IDM; INDOMETHACIN; KOL; KOLLIDON(®) VA 64; MECHANICAL PROPERTIES; ODF; ORODISPERSIBLE FILM; SOL; SOLUBILISING POLYMER RATIO; SOLUPLUS(®); TEC; TRIETHYL CITRATE;

ADMINISTRATION, ORAL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHLORPHENIRAMINE; DRUG DELIVERY SYSTEMS; HOT TEMPERATURE; INDOMETHACIN; POLYETHYLENE GLYCOLS; POLYVINYLS; POVIDONE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84883862707     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.046     Document Type: Article

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