Eritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma

Journal of Surgical Research

Volumn 184, Issue 2, 2013, Pages

  Korff, Sebastian ^a,b   Loughran, Patricia ^a   Cai, Chanchun ^a   Lee, Yi Shan ^a   Scott, Melanie ^a   Billiar, Timothy R ^a  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

DAMPs; Liver; Mice; Organ damage; Tight junctions; Toll like receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ERITORAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; INFLAMMATION; INTESTINE MUCOSA PERMEABILITY; LIVER INJURY; LIVER LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TISSUE INJURY; TISSUE LEVEL;

DAMPS; LIVER; MICE; ORGAN DAMAGE; TIGHT JUNCTIONS; TOLL-LIKE RECEPTOR;

ANIMALS; DISACCHARIDES; FEMORAL FRACTURES; INFLAMMATION; INTERLEUKIN-6; LYMPHOCYTE ANTIGEN 96; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NF-KAPPA B; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; SUGAR PHOSPHATES; TOLL-LIKE RECEPTOR 4; TRANSAMINASES; WOUNDS AND INJURIES;

EID: 84883857637     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.03.023     Document Type: Article

References (33)

1. WISQARS. National Center for Injury Prevention and Control. Center for Disease Control and Prevention 2007. 2007. 9-3-2011.Ref Type: Online Source. Available from: http://www.cdc.gov/injury/wisqars/index.html.
2. R.M. Levy, J.M. Prince, and R. Yang Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4 Am J Physiol Regul Integr Comp Physiol 291 2006 R970
3. J.M. Prince, R.M. Levy, and R. Yang Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock J Am Coll Surg 202 2006 407
4. J. Fan TLR cross-talk mechanism of hemorrhagic shock-primed pulmonary neutrophil infiltration Open Crit Care Med J 2 2010 1
5. K.P. Mollen, R.M. Levy, and J.M. Prince Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells J Leukoc Biol 83 2008 80
6. K.A. Barsness, J. Arcaroli, and A.H. Harken Hemorrhage-induced acute lung injury is TLR-4 dependent Am J Physiol Regul Integr Comp Physiol 287 2004 R592
7. H. Chen, E. Koustova, C. Shults, E.A. Sailhamer, and H.B. Alam Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challenge Resuscitation 74 2007 526
8. D.C. Reino, V. Pisarenko, and D. Palange Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice PLoS One 6 2011 e14829
9. L.J. McGhan, and D.E. Jaroszewski The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation Injury 43 2012 129
10. B.S. Park, D.H. Song, H.M. Kim, B.S. Choi, H. Lee, and J.O. Lee The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex Nature 458 2009 1191
11. M.L. DeMarco, and R.J. Woods From agonist to antagonist: structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins Mol Immunol 49 2011 124
12. S. Akira, and K. Takeda Toll-like receptor signalling Nat Rev Immunol 4 2004 499
13. R.M. Levy, K.P. Mollen, and J.M. Prince Systemic inflammation and remote organ injury following trauma require HMGB1 Am J Physiol Regul Integr Comp Physiol 293 2007 R1538
14. S.W. Montminy, N. Khan, and S. McGrath Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response Nat Immunol 7 2006 1066
15. M. Mullarkey, J.R. Rose, and J. Bristol Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist J Pharmacol Exp Ther 304 2003 1093
16. E. Bennett-Guerrero, H.P. Grocott, and J.H. Levy A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass Anesth Analg 104 2007 378
17. M. Liu, M. Gu, D. Xu, Q. Lv, W. Zhang, and Y. Wu Protective effects of Toll-like receptor 4 inhibitor eritoran on renal ischemia-reperfusion injury Transpl Proc 42 2010 1539
18. A. Shimamoto, A.J. Chong, and M. Yada Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury Circulation 114 2006 I270
19. R. Gill, X. Ruan, and C.J. Menzel Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells Shock 35 2011 164
20. K. Kawa, H. Tsutsui, and R. Uchiyama IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes Int Immunol 22 2010 157
21. P. Kobbe, D.J. Kaczorowski, and Y. Vodovotz Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury Shock 30 2008 686
22. S. Korff, R. Falsafi, and C. Czerny Time dependency and topography of hepatic NF-kappaB activation after hemorrhagic shock and resuscitation in mice Shock 38 2012 486
23. R. Yang, D.J. Gallo, and J.J. Baust Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock Am J Physiol Gastrointest Liver Physiol 283 2002 G212
24. M.D. Luyer, W.A. Buurman, and M. Hadfoune Pretreatment with high-fat enteral nutrition reduces endotoxin and tumor necrosis factor-alpha and preserves gut barrier function early after hemorrhagic shock Shock 21 2004 65
25. J. Fan, Y. Li, Y. Vodovotz, T.R. Billiar, and M.A. Wilson Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation Am J Physiol Lung Cell Mol Physiol 290 2006 L738
26. K.P. Mollen, R.J. Anand, A. Tsung, J.M. Prince, R.M. Levy, and T.R. Billiar Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage Shock 26 2006 430
27. A. Tsung, J.R. Klune, and X. Zhang HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling J Exp Med 204 2007 2913
28. K.A. Powers, K. Szaszi, and R.G. Khadaroo Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages J Exp Med 203 2006 1951
29. J. Fan, Y. Li, Y. Vodovotz, T.R. Billiar, and M.A. Wilson Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS Shock 28 2007 213
30. S. Ehrentraut, R. Lohner, and M. Schwederski In vivo toll-like receptor 4 antagonism restores cardiac function during endotoxemia Shock 36 2011 613
31. M. Tidswell, W. Tillis, and S.P. LaRosa Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis Crit Care Med 38 2010 72
32. A. Barochia, S. Solomon, X. Cui, C. Natanson, and P.Q. Eichacker Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies Expert Opin Drug Metab Toxicol 7 2011 479
33. Y.N. Wong, D. Rossignol, J.R. Rose, R. Kao, A. Carter, and M. Lynn Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study J Clin Pharmacol 43 2003 735