Palladium catalyzed cyclizations of oxime esters with 1,2-disubstituted alkenes: Synthesis of dihydropyrroles

Organic Letters

Volumn 15, Issue 17, 2013, Pages 4616-4619

  Race, Nicholas J ^a   Bower, John F ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

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Indexed keywords

EID: 84883819298     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol4023112     Document Type: Article

References (20)

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20. We favor a cationic aza-Heck pathway as depicted in Scheme 4b because electron deficient leaving groups are required for efficient cyclization. The corresponding benzoyl oxime esters are active for oxidative addition (see: Nishimura, T.; Nishiguchi, Y.; Maeda, Y.; Uemura, S. J. Org. Chem. 2004, 69, 5342) but provide traces of cyclization product under the conditions described here