Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma

Neuropharmacology

Volumn 75, Issue , 2013, Pages 380-390

  Savigni, Donna L ^a   O'Hare Doig, Ryan L ^a   Szymanski, Charis R ^a   Bartlett, Carole A ^a   Lozić, Ivan ^a   Smith, Nicole M ^a   Fitzgerald, Melinda ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Ca2+ channel inhibitors; Myelin; Myelin compaction; Neurotrauma; Node paranode complex; Oxidative stress; Secondary degeneration; Visual system

Indexed keywords

2 [7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1,2,3,4 TETRAHYDRO QUINOXALIN 1 YL]ACETIC ACID; CALCIUM CHANNEL BLOCKING AGENT; LOMERIZINE; MYELIN; OXIDISED ADENOSINE TRIPHOSPHATE; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; ADENOSINE TRIPHOSPHATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CASPR PROTEIN, RAT; DIAGNOSTIC AGENT; N METHYL DEXTRO ASPARTIC ACID; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; OLIG1 PROTEIN, RAT; PARAFORMALDEHYDE; PHOSPHATE BUFFERED SALINE; PIPERAZINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE DURATION; DRUG ACTIVITY; FEMALE; KINETICS; MONOTHERAPY; NERVE DEGENERATION; NERVE FIBER; NERVOUS SYSTEM INJURY; NONHUMAN; OPTIC NERVE DISEASE; OPTIC NERVE SWELLING; OPTIC NERVE TRANSECTION; OPTOKINETIC NYSTAGMUS; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; TISSUE PRESERVATION; VISION; VISUAL REFLEX; Α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; 2-[7-(1H-IMIDAZOL-1-YL)-6-NITRO-2,3-DIOXO-1,2,3,4-TETRAHYDRO QUINOXALIN-1-YL]ACETIC ACID; ANIMAL; CA(2+) CHANNEL INHIBITORS; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; I.P.; INQ; INTRAPERITONEALLY; LOM; METABOLISM; MYELIN COMPACTION; N-METHYL-D-ASPARTIC ACID; NODE/PARANODE COMPLEX; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCT; OLIGODENDROCYTE PRECURSOR CELLS; ON; OPCS; OPTIC NERVE; OPTIC NERVE INJURY; OPTICAL CUTTING TEMPERATURE; OXATP; OXIDISED ADENOSINE-TRIPHOSPHATE; PAPILLEDEMA; PARTIAL TRANSECTION; PATHOLOGY; PBS; PFA; PT; RANVIER NODE; RGC; SCANNING ELECTRON MICROSCOPY; SECONDARY DEGENERATION; STANDARD ERROR OF THE MEAN; TEM; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VGCCS; VISUAL SYSTEM; VOLTAGE-GATED CALCIUM CHANNELS;

Α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; 2-[7-(1H-IMIDAZOL-1-YL)-6-NITRO-2,3-DIOXO-1,2,3,4-TETRAHYDRO QUINOXALIN-1-YL]ACETIC ACID; ADENOSINE TRIPHOSPHATE; AMPA; ATP; CA(2+) CHANNEL INHIBITORS; I.P.; INQ; INTRAPERITONEALLY; LOM; LOMERIZINE; MYELIN; MYELIN COMPACTION; N-METHYL-D-ASPARTIC ACID; NEUROTRAUMA; NMDA; NODE/PARANODE COMPLEX; OCT; OLIGODENDROCYTE PRECURSOR CELLS; ON; OPCS; OPTIC NERVE; OPTICAL CUTTING TEMPERATURE; OXATP; OXIDATIVE STRESS; OXIDISED ADENOSINE-TRIPHOSPHATE; PARAFORMALDEHYDE; PARTIAL TRANSECTION; PBS; PFA; PHOSPHATE BUFFERED SALINE; PT; RETINAL GANGLION CELL; RGC; SECONDARY DEGENERATION; SEM; STANDARD ERROR OF THE MEAN; TEM; TRANSMISSION ELECTRON MICROSCOPY; VGCCS; VISUAL SYSTEM; VOLTAGE-GATED CALCIUM CHANNELS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM CHANNEL BLOCKERS; CELL ADHESION MOLECULES, NEURONAL; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NYSTAGMUS, OPTOKINETIC; OPTIC NERVE; OPTIC NERVE INJURIES; PAPILLEDEMA; PIPERAZINES; RANVIER'S NODES; RATS; RETINAL GANGLION CELLS; TETRAHYDROISOQUINOLINES; TRITIUM;

EID: 84883815057     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.07.034     Document Type: Article

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