Multiple functions of the paranodal junction of myelinated nerve fibers

Journal of Neuroscience Research

Volumn 87, Issue 15, 2009, Pages 3250-3258

  Rosenbluth, Jack ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Demyelination; Dysmyelination; Multiple sclerosis; Myelin

Indexed keywords

BREVICAN; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; ASTROCYTE; AXOPLASM; CELL FUNCTION; CELL JUNCTION; CELL MEMBRANE; CRYSTAL STRUCTURE; CYTOSKELETON; DEPOLARIZATION; EXTRACELLULAR SPACE; GLIA CELL; IMMUNOFLUORESCENCE; MECHANICAL STRESS; MYELIN SHEATH; MYELINATED NERVE; NERVE BLOCK; NERVE CONDUCTION; NERVE FIBER MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RANVIER NODE; REVIEW; SALINITY; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ANIMALS; CELL MEMBRANE; ENERGY METABOLISM; HUMANS; ION CHANNELS; MYELIN SHEATH; NERVE FIBERS, MYELINATED; NEURAL CONDUCTION; RANVIER'S NODES; STRESS, MECHANICAL;

EID: 70449360192     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22013     Document Type: Review

References (66)

1. Andres KH. 1965. Uber die Feinstruktur besonderer Einrichtungen in markhaltigen Nervenfasern des Kleinhirns der Ratte. Z Zellforsch 65:701-712.
2. Arroyo EJ, Xu T, Grinspan J, Lambert SS, Levinson SR, Brophy PB, Peles E, Scherer S. 2002. Genetic dysmyelination alters the molecular architecture of the nodal region. J Neurosci 22:1726-1737. (Pubitemid 35386291)
3. Bargmann W, Lindner E. 1964. Uber den Feinbau des Nebennierenmarkes des Igels (Erinaceous europaeus L). Z Zellforsch 64:868-912.
4. Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St. Martin M, Li J, Einheber S, Chesler M, Rosenbluth J, Salzer JL, Bellen HJ. 2001. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/paranodin. Neuron 30:369-383. (Pubitemid 32530582)
5. Boyle ME, Berglund EO, Murai KK, Weber L, Peles E, Ranscht B. 2001. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron 30:385-397. (Pubitemid 32530583)
6. Bray GM, Cullen MJ, Aguayo AJ, Rasminsky M. 1980. Node-like areas of intramembranous particles in the unsheathed axons of dystrophic mice. Neurosci Lett 13:203-208. (Pubitemid 9232279)
7. Chiu SY. 1980. Asymmetry currents in the mammalian myelinated nerve. J Physiol 309:499-519.
8. Chiu SY, Ritchie JM. 1980. Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature 284:170-171.
9. Chiu SY, Zhou L, Zhang C-L, Messing A. 1999. Analysis of potassium channel functions in mammalian axons by gene knockouts. J Neurocytol 28:349-364. (Pubitemid 30321015)
10. Custer AW, Kazarinova-Noyes K, Sakurai T, Xu X, Simon W, Grumet M, Shrager P. 2003. The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. J Neurosci 23:10032-10039. (Pubitemid 37392549)
11. David G, Barrett JN, Barrett EF. 1993. Activation of internodal potassium conductance in rat myelinated axons. J Physiol 472:177-202. (Pubitemid 24015001)
12. Deerinck TJ, Levinson SR, Bennett GV, Ellisman MH. 1997. Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. J Neurosci 17:5080-5088.
13. + channels and node of Ranvier formation in remyelinating axons. J Neurosci 15:492-503.
14. Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B. 1998. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. J Neurosci 18:1642-1649. (Pubitemid 28103072)
15. Einheber S, Zanazzi G, Ching W, Scherer S, Milner TA, Peles E, Salzer JL. 1997. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination. J Cell Biol 139:1495-1506. (Pubitemid 28013670)
16. Elfvin LG. 1961. The ultrastructure of nodes of Ranvier in cat sympathetic fibers. J Ultrastruct Res 5:374-387.
17. Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig-Nadir O, Spiegel I, Bermingham JR Jr, Peles E. 2005. Gliomedin mediates Schwann cellaxon interaction and the molecular assembly of the nodes of Ranvier. Neuron 47:215-229. (Pubitemid 41019253)
18. Eshed Y, Feinberg K, Carey DJ, Peles E. 2007. Secreted gliomedin is a perinodal matrix component of peripheral nerves. J Cell Biol 177:551-562. (Pubitemid 46718282)
19. Garcia-Fresco GP, Sousa AD, Pillai AM, Moy SS, Crawley JN, Tessarollo L, Dupree JL, Bhat MA. 2006. Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc Natl Acad Sci USA 103:5137-5142.
20. Gordon TR, Kocsis JD, Waxman SG. 1989. Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve. Brain Res 502:252-257.
21. Griffin JW, Li CY, Macko C, Ho TW, Hsieh ST, Xue P, Wang FA, Cornblath DR, McKhann GM, Asbury AK. 1996. Early nodal changes in the acute motor axonal neuropathy pattern of the Guillain-Barré syndrome. J Neurocytol 25:33-51. (Pubitemid 126425609)
22. Hirano A, Dembitzer HM. 1969. The transverse bands as a means of access to the periaxonal space of the central myelinated fibre. J Ultrastruct Res 28:141-149.
23. Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y, Taniguchi N. 2002. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci USA 99:4227-4232. (Pubitemid 34285968)
24. Huxley AF, Staempfli R. 1949. Evidence for saltatory conduction in peripheral myelinated nerve fibers. J Physiol 108:315-339.
25. Ikeda K, Tomita K, Tanaka S. 2000. Experimental study of peripheral nerve injury during gradual limb elongation. Hand Surg 5:41-47.
26. Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE. 2008. Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. J Neurosci 28:11003-11014.
27. Kaplan MR, Meyer-Franke A, Lambert S, Bennett V, Duncan ID, Levinson SR, Barres BA. 1997. Induction of sodium channel clustering by oligodendrocytes. Nature 386:724-728. (Pubitemid 27193494)
28. + channels: subunit specificity correlates with clinical manifestations. Brain 129:1570-1584.
29. Kocsis JD, Waxman SG. 1980. Absence of potassium conductance in central myelinated axons. Nature 287:348-349.
30. Livingston RB, Pfenniger K, Moor H, Akert K. 1973. Specialized paranodal and interparanodal glial-axonal junctions in the peripheral and central nervous system: a freeze-etching study. Brain Res 58:1-24.
31. Maxwell WL, Kosanlavit R, McCreath BJ, Reid O, Graham DI. 1999. Freeze-fracture and cytochemical evidence for structural and functional alteration in the axolemma and myelin sheath of adult guinea pig optic nerve fibers after stretch injury. J Neurotrauma 16:273-284. (Pubitemid 29200821)
32. Menegoz M, Gaspar P, Le Bert M, Galvez T, Burgaya F, Palfrey C, Ezan P, Arnos F, Girault JA. 1997. Paranodin, a glycoprotein of neuronal paranodal membranes. Neuron 19:319-331. (Pubitemid 27374231)
33. Mierzwa A, Rosenbluth J. 2006. Lateral permeability of the paranodal junction in myelinated nerve fibers. Soc Neurosci Abstr 638.6.
34. Moore JW, Joyner RW, Brill MH, Waxman SD, Najar-Joa M. 1978. Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters. Biophys J 21:147-160.
35. Moran O, Mateu L. 1983. Loosening of paranodal myelin by repetitive propagation of action potentials. Nature 304:344-345.
36. Ogawa Y, Schafer DP, Horresh I, Bar V, Hales K, Yang Y, Susuki K, Peles E, Stankewich MC, Rasband MN. 2006. Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton. J Neurosci 26:5230-5239. (Pubitemid 44315305)
37. Ogawa Y, Susuki K, Eshed Y, Peles E, Rasband MN. 2008. Molecular mechanisms of CNS node of Ranvier formation. Soc Neurosci Abstr 241.16.
38. Rasband MN, Shrager P. 2000. Ion channel sequestration in central nervous system axons. J Physiol 525:63-73. (Pubitemid 30311934)
39. Rasband MN, Trimmer JS, Peles E, Levinson SR, Shrager P. 1999a. K1 channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol 28:319-331. (Pubitemid 30321013)
40. Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P. 1999b. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci 19:7516-7528. (Pubitemid 29404608)
41. Rasband MN, Taylor CM, Bansal R. 2003. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons. Glia 44:173-182. (Pubitemid 37345627)
42. Rios JC, Rubin M, St. Martin M, Downey RT, Einheber S, Rosenbluth J, Levinson SR, Bhat M, Salzer JL. 2003. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J Neurosci 23:7001-7011. (Pubitemid 36975866)
43. Robertson JD. 1958. The ultrastructure of Schmidt-Lanterman clefts and related shearing defects of the myelin sheath. J Biophys Biochem Cytol 4:39-46.
44. Robertson JD. 1959. Preliminary observations on the ultrastructure of nodes of Ranvier. Z Zellforsch 50:553-560.
45. Rosenbluth J. 1976. Intramembranous particle distribution at the node of Ranvier and adjacent axolemma in myelinated axons of the frog brain. J Neurocytol 5:731-745.
46. Rosenbluth J. 1979. Aberrant axon-Schwann cell junctions in dystrophic mouse nerves. J Neurocytol 8:655-672. (Pubitemid 10192279)
47. Rosenbluth J. 1984. Membrane specializations at the nodes of Ranvier and paranodal and juxtaparanodal regions of myelinated central and peripheral nerve fibers. In: Zagoren JC, Fedoroff S, editors. The node of Ranvier. New York: Academic Press. p 31-67.
48. Rosenbluth J. 1987. Abnormal axoglial junctions in the myelin-deficient rat mutant. J Neurocytol 16:497-509. (Pubitemid 17140505)
49. Rosenbluth J. 1995. Pathology of demyelinated and dysmyelinated axons. In: Waxman SG, Kocsis JD, Stys PK, editors. The axon. New York: Oxford University Press.
50. Rosenbluth J, Dupree JL, Popko B. 2003. Nodal sodium channel domain integrity depends on the conformation of the paranodal junction, not on the presence of transverse bands. Glia 41:318-325. (Pubitemid 36258475)
51. Rosenbluth J, Nave KA, Mierzwa A, Schiff R. 2006. Subtle myelin defects in PLP-null mice. Glia 54:172-182. (Pubitemid 44230854)
52. Rosenbluth J, Mierzwa A, Arevalo M, Chao M. 2008. Correlation between transverse bands and lifespan in dysmyelinated mice. Soc Neurosci Abstr 251.10.
53. Salzer JL, Brophy PJ, Peles E. 2008. Molecular domains of myelinated axons in the peripheral nervous system. Glia 56:1532-1540.
54. Schnapp B, Mugnaini E. 1975. The myelin sheath. Electron microscopic studies with thin sections and freeze-fracture. In: Santini M, editor. Golgi Centennial Symposium proceedings. New York: Raven Press. p 209-233.
55. Sherman DL, Tait S, Melrose S, Johnson R, Zonta B, Court FA, Macklin WB, Meek S, Smith AJ, Cottrell DF, Brophy PJ. 2005. Neurofascins are required to establish axonal domains for saltatory conduction. Neuron 48:737-742. (Pubitemid 41759425)
56. Sherratt RM, Bostock H, Sears TA. 1980. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature 283:570-573. (Pubitemid 10136031)
57. Shrager P. 1989. Sodium channels in single demyelinated mammalian fibers. Brain Res 483:149-154. (Pubitemid 19082450)
58. Stys PK, Waxman SG. 1994. Activity-dependent modulation of excitability: implications for axonal physiology and pathophysiology. Muscle Nerve 17:969-974.
59. Tao-Cheng J-H, Rosenbluth J. 1982. Development of nodal and paranodal membrane specializations in amphibian peripheral nerves. Brain Res Dev Brain Res 3:577-594. (Pubitemid 12076307)
60. Taylor CM, Marta CB, Claycomb RJ, Han DK, Rasband MN, Coetzee T, Pfeiffer SE. 2004. Proteomic mapping provides powerful insights into functional myelin biology. Proc Natl Acad Sci USA 101:4643-4648. (Pubitemid 38437464)
61. Vabnick I, Trimmer JS, Schwarz TL, Levinson SR, Risal D, Shrager P. 1999. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J Neurosci 19:747-758. (Pubitemid 29036026)
62. Vincent A. 2004. Antibody-mediated disorders of neuromuscular transmission. Suppl Clin Neurophysiol 57:147-158.
63. + channels in terminal and juxtaparanodal regions of axons. Nature 365:75-79.
64. Young W, Rosenbluth J, Wojak JC, Sakatani K, Kim H. 1989. Extracellular potassium activity and axonal conduction in spinal cord of the myelin-deficient mutant rat. Exp Neurol 106:41-51. (Pubitemid 19246448)
65. Yu RC, Bunge RP. 1975. Damage and repair of the peripheral myelin sheath and node of Ranvier after treatment with trypsin. J Cell Biol 64:1-14.
66. Zonta B, Tait S, Melrose S, Anderson H, Harroch S, Higginson J, Sherman DL, Brophy PJ. 2008. Glial and neuronal isoforms of neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system. J Cell Biol 181:1169-1177. (Pubitemid 351915490)