Dynamic kinetic resolution-based asymmetric transfer hydrogenation of 2-benzoylmorpholinones and its use in concise stereoselective synthesis of all four stereoisomers of the antidepressant reboxetine

Journal of Organic Chemistry

Volumn 78, Issue 17, 2013, Pages 8396-8404

  Son, Se Mi ^a,b   Lee, Hyeon Kyu ^a,b  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC TRANSFER HYDROGENATION; DIASTEREO- AND ENANTIOSELECTIVITY; REBOXETINE; SIMULTANEOUS CONTROL; SINGLE-STEP; STEREOGENIC CENTERS; STEREOSELECTIVE SYNTHESIS;

HYDROGENATION; STEREOSELECTIVITY;

STEREOCHEMISTRY;

2 (HYDROXYPHENYLMETHYL) MORPHOLIN 3 ONE; 2 BENZOYLMORPHOLIN 3 ONE; 2 BENZOYLMORPHOLINONE DERIVATIVE; MORPHOLINE DERIVATIVE; REBOXETINE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; DRUG STRUCTURE; ENANTIOSELECTIVITY; HYDROGENATION; KINETICS; STEREOCHEMISTRY; STEREOISOMERISM;

ANTIDEPRESSIVE AGENTS; HYDROGENATION; KINETICS; MOLECULAR STRUCTURE; MORPHOLINES; STEREOISOMERISM; THERMODYNAMICS;

EID: 84883800884     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401102d     Document Type: Article

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