The cardioprotection of simvastatin in reperfused swine hearts relates to the inhibition of myocardial edema by modulating aquaporins via the PKA pathway

International Journal of Cardiology

Volumn 167, Issue 6, 2013, Pages 2657-2666

  Li, Xiang Dong ^a   Yang, Yue Jin ^a   Geng, Yong Jian ^b   Cheng, Yu Tong ^c   Zhang, Hai Tao ^a   Zhao, Jing Lin ^a   Yuan, Jin Qin ^a   Gao, Run Lin ^a  

^a FUWAI HOSPITAL   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Aquaporins; Ischemia reperfusion injury; Myocardial edema; No reflow; Protein kinase A; Statins

Indexed keywords

AQUAPORIN 1; AQUAPORIN 4; AQUAPORIN 8; AQUAPORIN 9; CYCLIC AMP DEPENDENT PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; EDEMA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; LOADING DRUG DOSE; MINIPIG; MYOCARDIAL EDEMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT RESPONSE; WATER CONTENT;

AQUAPORINS; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL EDEMA; NO-REFLOW; PROTEIN KINASE A; STATINS;

ANIMALS; AQUAPORINS; CARDIOTONIC AGENTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EDEMA; MYOCARDIAL REPERFUSION INJURY; SIGNAL TRANSDUCTION; SIMVASTATIN; SWINE; SWINE, MINIATURE;

EID: 84883793001     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.06.121     Document Type: Article

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