T2-weighted cardiovascular magnetic resonance in acute cardiac disease

Journal of Cardiovascular Magnetic Resonance

Volumn 13, Issue 1, 2011, Pages

  Eitel, Ingo ^a,b   Friedrich, Matthias G ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

WATER;

ACUTE CORONARY SYNDROME; ACUTE DISEASE; ACUTE HEART INFARCTION; BLEEDING; CARDIOVASCULAR MAGNETIC RESONANCE; CHRONIC DISEASE; CLINICAL ASSESSMENT; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ECHOCARDIOGRAPHY; HEART DISEASE; HEART EDEMA; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HIGH RISK PATIENT; HUMAN; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SIGNAL NOISE RATIO; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TAKOTSUBO CARDIOMYOPATHY; WATER CONTENT; COMPUTER ASSISTED DIAGNOSIS; DIFFUSION WEIGHTED IMAGING; HOSPITALIZATION; PREDICTIVE VALUE;

ACUTE DISEASE; DIAGNOSIS, DIFFERENTIAL; DIFFUSION MAGNETIC RESONANCE IMAGING; HEART DISEASES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SEVERITY OF ILLNESS INDEX;

EID: 79958853059     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-13-13     Document Type: Review

References (88)

1. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, et al. J Am Coll Cardiol 2010 55 2614 2662 10.1016/j.jacc.2009.11.011 20513610
2. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, et al. Eur Heart J 2004 25 1940 1965 10.1016/j.ehj.2004.06. 040 15522474 (Pubitemid 39452612)
3. EuroCMR (European Cardiovascular Magnetic Resonance) registry: results of the German pilot phase. Bruder O, Schneider S, Nothnagel D, Dill T, Hombach V, Schulz-Menger J, et al. J Am Coll Cardiol 2009 54 1457 1466 10.1016/j.jacc.2009. 07.003 19682818
4. Acute coronary syndrome: emerging tools for diagnosis and risk assessment. Scirica BM, J Am Coll Cardiol 2010 55 1403 1415 10.1016/j.jacc.2009. 09.071 20359589
5. Tissue characterization of acute myocardial infarction and myocarditis by cardiac magnetic resonance. Friedrich MG, JACC Cardiovasc Imaging 2008 1 652 662 10.1016/j.jcmg.2008.07.011 19356496
6. Myocardial edema - a new clinical entity? Friedrich MG, Nat Rev Cardiol 2010 7 292 296 20309007
7. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, et al. Circulation 2004 109 2411 2416 10.1161/01.CIR.0000127428.10985.C6 15123531 (Pubitemid 38679560)
8. Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. Cury RC, Shash K, Nagurney JT, Rosito G, Shapiro MD, Nomura CH, et al. Circulation 2008 118 837 844 10.1161/CIRCULATIONAHA.107.740597 18678772
9. Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome. Raman SV, Simonetti OP, Winner MW III, Dickerson JA, He X, Mazzaferri EL Jr, et al. J Am Coll Cardiol 2010 55 2480 2488 10.1016/j.jacc.2010.01.047 20510215
10. Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt RF Jr, et al. Circulation 2006 113 1865 1870 10.1161/CIRCULATIONAHA.105. 576025 16606793 (Pubitemid 43739398)
11. In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Tilak GS, Hsu LY, Hoyt RF Jr, Arai AE, Aletras AH, Invest Radiol 2008 43 7 15 10.1097/RLI.0b013e3181558822 18097272
12. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R, J Am Coll Cardiol 2008 51 1581 1587 10.1016/j.jacc.2008.01.019 18420102 (Pubitemid 351508364)
13. Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, et al. J Am Coll Cardiol 2010 55 2470 2479 10.1016/j.jacc.2010.01.049 20510214
14. Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence. Marie PY, Angioi M, Carteaux JP, Escanye JM, Mattei S, Tzvetanov K, et al. J Am Coll Cardiol 2001 37 825 831 10.1016/S0735-1097(00)01196-7 11693758 (Pubitemid 32202451)
15. Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: a review. Butler CR, Thompson R, Haykowsky M, Toma M, Paterson I, J Cardiovasc Magn Reson 2009 11 7 10.1186/1532-429X-11-7 19284612
16. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. Abdel-Aty H, Boye P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, et al. J Am Coll Cardiol 2005 45 1815 1822 10.1016/j.jacc.2004.11.069 15936612 (Pubitemid 40779862)
17. Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT, et al. J Am Coll Cardiol 2009 53 1475 1487 10.1016/j.jacc.2009.02.007 19389557
18. Myocardial edema is a feature of Tako-Tsubo cardiomyopathy and is related to the severity of systolic dysfunction: Insights from T2-weighted cardiovascular magnetic resonance. Abdel-Aty H, Cocker M, Friedrich MG, Int J Cardiol 2009 132 291 293 10.1016/j.ijcard.2007.08.102 18086501
19. Differential diagnosis of suspected apical ballooning syndrome using contrast enhanced magnetic resonance imaging. Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, et al. Eur Heart J 2008 29 2651 2659 10.1093/eurheartj/ehn433 18820322
20. Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. Eitel I, Lucke C, Grothoff M, Sareban M, Schuler G, Thiele H, et al. Eur Radiol 2010 20 422 431 10.1007/s00330-009-1549-5 19705125
21. Accumulation of hyaluronan and tissue edema in experimental myocardial infarction. Waldenstrom A, Martinussen HJ, Gerdin B, Hallgren R, J Clin Invest 1991 88 1622 1628 10.1172/JCI115475 1939649
22. Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study. Abdel-Aty H, Cocker M, Meek C, Tyberg JV, Friedrich MG, J Am Coll Cardiol 2009 53 1194 1201 10.1016/j.jacc.2008.10.065 19341860
23. Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure. Jennings RB, Schaper J, Hill ML, Steenbergen C Jr, Reimer KA, Circ Res 1985 56 262 278 3971504 (Pubitemid 15131388)
24. Myocardial oedema: a preventable cause of reperfusion injury? Garcia-Dorado D, Oliveras J, Cardiovasc Res 1993 27 1555 1563 10.1093/cvr/27.9.1555 8287430 (Pubitemid 23297516)
25. Myocardial edema, left ventricular function, and pulmonary hypertension. Davis KL, Mehlhorn U, Laine GA, Allen SJ, J Appl Physiol 1995 78 132 137 10.1063/1.360663 7713802
26. The effects of cardiopulmonary bypass with crystalloid and colloid hemodilution on myocardial extravascular water. Laks H, Standeven J, Blair O, Hahn J, Jellinek M, Willman VL, J Thorac Cardiovasc Surg 1977 73 129 138 831003 (Pubitemid 8055554)
27. Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Mehlhorn U, Davis KL, Burke EJ, Adams D, Laine GA, Allen SJ, Am J Physiol 1995 268 178 H183 7840262
28. Cardiopulmonary bypass and edema: physiology and pathophysiology. Hirleman E, Larson DF, Perfusion 2008 23 311 322 10.1177/0267659109105079 19454559
29. Early change of myocardial water during acute cardiac allograft rejection. Sasaguri S, Sunamori M, Saito K, Suzuki A, Jpn Circ J 1986 50 1113 1119 3546764 (Pubitemid 17002911)
30. The role of myocardial edema in the left ventricular diastolic stiffness. Pogatsa G, Dubecz E, Gabor G, Basic Res Cardiol 1976 71 263 269 10.1007/BF01906451 938438
31. Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function. Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA, Cardiovasc Res 2010 87 331 229 10.1093/cvr/cvq145 20472566
32. Microvascular, interstitial, and lymphatic interactions in normal heart. Laine GA, Granger HJ, Am J Physiol 1985 249 834 H842 4051019
33. Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs. DiBona DR, Powell WJ Jr, Circ Res 1980 47 653 665 7418125
34. Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Desai KV, Laine GA, Stewart RH, Cox CS Jr, Quick CM, Allen SJ, et al. Am J Physiol Heart Circ Physiol 2008 294 2428 H2434 10.1152/ajpheart.00860.2007 18375722
35. Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Laine GA, Allen SJ, Circ Res 1991 68 1713 1721 2036720
36. Hydration of macromolecules. Kuntz ID Jr, Brassfield TS, Law GD, Purcell GV, Science 1969 163 1329 1331 10.1126/science.163.3873.1329 5765111
37. Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first? Kloner RA, Rude RE, Carlson N, Maroko PR, DeBoer LW, Braunwald E, Circulation 1980 62 945 952 7418179 (Pubitemid 11225959)
38. Serial nuclear magnetic resonance imaging of acute myocardial infarction with and without reperfusion. Wisenberg G, Prato FS, Carroll SE, Turner KL, Marshall T, Am Heart J 1988 115 510 518 10.1016/0002-8703(88)90798-3 3344656 (Pubitemid 18081116)
39. The histopathologic evolution of myocardial infarction. Fishbein MC, Maclean D, Maroko PR, Chest 1978 73 843 849 10.1378/chest.73.6.843 657859 (Pubitemid 8374473)
40. Cardiovascular magnetic resonance of acute myocardial infarction at a very early stage. Schulz-Menger J, Gross M, Messroghli D, Uhlich F, Dietz R, Friedrich MG, J Am Coll Cardiol 2003 42 513 518 10.1016/S0735-1097(03)00717-4 12906982 (Pubitemid 36951720)
41. Sustained postinfarction myocardial oedema in humans visualised by magnetic resonance imaging. Nilsson JC, Nielsen G, Groenning BA, Fritz-Hansen T, Sondergaard L, Jensen GB, et al. Heart 2001 85 639 642 10.1136/heart.85.6.639 11359743 (Pubitemid 32973458)
42. Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging. Ripa RS, Nilsson JC, Wang Y, Sondergaard L, Jorgensen E, Kastrup J, Am Heart J 2007 154 929 936 10.1016/j.ahj.2007.06.038 17967600 (Pubitemid 47632488)
43. High-frequency ultrasound for quantitative characterization of myocardial edema. Dent CL, Scott MJ, Wickline SA, Hall CS, Ultrasound Med Biol 2000 26 375 384 10.1016/S0301-5629(99)00144-1 10773367 (Pubitemid 30204549)
44. Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts. Powell WJ Jr, wittenberg J, Maturi RA, Dinsmore RE, Miller SW, Circulation 1977 55 99 108 851470 (Pubitemid 8015597)
45. Assessment of myocardial edema by computed tomography in myocardial infarction. Mahnken AH, Bruners P, Bornikoel CM, Kramer N, Guenther RW, JACC Cardiovasc Imaging 2009 2 1167 1174 10.1016/j.jcmg.2009.05.014 19833305
46. T2-weighted cardiovascular magnetic resonance imaging. Abdel-Aty H, Simonetti O, Friedrich MG, J Magn Reson Imaging 2007 26 452 459 10.1002/jmri.21028 17729358 (Pubitemid 350194566)
47. T2-weighted magnetic resonance imaging to assess myocardial oedema in ischaemic heart disease. Edwards NC, Routledge H, Steeds RP, Heart 2009 95 1357 1361 10.1136/hrt.2009.169961 19447836
48. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al. Am J Cardiol 1983 52 184 188 10.1016/0002-9149(83)90093-0 6858909 (Pubitemid 13061350)
49. Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Hazlewood CF, Chang DC, Nichols BL, Woessner DE, Biophys J 1974 14 583 606 10.1016/S0006-3495(74)85937-0 4853385
50. Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D, Stroke 1991 22 802 808 2057981
51. "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Simonetti OP, Finn JP, White RD, Laub G, Henry DA, Radiology 1996 199 49 57 8633172
52. An improved MR imaging technique for the visualization of myocardial infarction. Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, et al. Radiology 2001 218 215 223 11152805 (Pubitemid 32151298)
53. Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction. Mikami Y, Sakuma H, Nagata M, Ishida M, Kurita T, Komuro I, et al. AJR Am J Roentgenol 2009 193 321 W326 10.2214/AJR.09.2335 19770302
54. T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo. Kellman P, Aletras AH, Mancini C, McVeigh ER, Arai AE, Magn Reson Med 2007 57 891 897 10.1002/mrm.21215 17457880 (Pubitemid 46709409)
55. ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart. Aletras AH, Kellman P, Derbyshire JA, Arai AE, Magn Reson Med 2008 59 229 235 10.1002/mrm.21490 18228588 (Pubitemid 351220085)
56. Single-shot steady-state free precession can detect myocardial edema in patients: a feasibility study. Green JD, Clarke JR, Flewitt JA, Friedrich MG, J Magn Reson Imaging 2009 30 690 695 10.1002/jmri.21868 19634173
57. T2 quantification for improved detection of myocardial edema. Giri S, Chung YC, Merchant A, Mihai G, Rajagopalan S, Raman SV, et al. J Cardiovasc Magn Reson 2009 11 56 10.1186/1532-429X-11-56 20042111
58. Molecular imaging: T2-weighted CMR of the area at risk - a risky business? Wince WB, Kim RJ, Nat Rev Cardiol 2010 7 547 549 10.1038/nrcardio. 2010.124 20865026
59. Improved turbo spin-echo imaging of the heart with motion-tracking. Keegan J, Gatehouse PD, Prasad SK, Firmin DN, J Magn Reson Imaging 2006 24 563 570 10.1002/jmri.20655 16878314 (Pubitemid 44320558)
60. Use of cardiovascular magnetic resonance imaging in acute coronary syndromes. Lockie T, Nagel E, Redwood S, Plein S, Circulation 2009 119 1671 1681 10.1161/CIRCULATIONAHA.108.816512 19332480
61. Staged cardiovascular magnetic resonance for differential diagnosis of Troponin T positive patients with low likelihood for acute coronary syndrome. Steen H, Madadi-Schroeder M, Lehrke S, Lossnitzer D, Giannitsis E, Katus HA, J Cardiovasc Magn Reson 2010 12 51 10.1186/1532-429X-12-51 20840783
62. Using magnetic resonance imaging to characterize recent myocardial injury: utility in acute coronary syndrome and other clinical scenarios. Arai AE, Circulation 2008 118 795 796 10.1161/CIRCULATIONAHA.108.797373 18711021
63. The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries. Assomull RG, Lyne JC, Keenan N, Gulati A, Bunce NH, Davies SW, et al. Eur Heart J 2007 28 1242 1249 10.1093/eurheartj/ehm113 17478458 (Pubitemid 47343853)
64. Prognostic significance and magnetic resonance imaging findings in aborted myocardial infarction after primary angioplasty. Eitel I, Desch S, Sareban M, Fuernau G, Gutberlet M, Schuler G, et al. Am Heart J 2009 158 806 813 10.1016/j.ahj.2009.08.025 19853702
65. Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction. Masci PG, Ganame J, Strata E, Desmet W, Aquaro GD, Dymarkowski S, et al. JACC Cardiovasc Imaging 2010 3 45 51 10.1016/j.jcmg.2009.06.016 20129530
66. Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: Insight from cardiovascular magnetic resonance. Francone M, Bucciarelli-Ducci C, Carbone I, Canali E, Scardala L, Calabrese FA, et al. J Am Coll Cardiol 2009 54 2145 2153 10.1016/j.jacc.2009.08.024 19942086
67. Quantification of myocardial area at risk with T2-weighted CMR: comparison with contrast-enhanced CMR and coronary angiography. Wright J, Adriaenssens T, Dymarkowski S, Desmet W, Bogaert J, JACC Cardiovasc Imaging 2009 2 825 831 10.1016/j.jcmg.2009.02.011 19608131
68. Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. Carlsson M, Ubachs JF, Hedstrom E, Heiberg E, Jovinge S, Arheden H, JACC Cardiovasc Imaging 2009 2 569 576 10.1016/j.jcmg.2008.11.018 19442942
69. Reproducibility of myocardial salvage in acute myocardial infarction by the use of contrast-enhanced magnetic resonance imaging [abstract]. Thiele H, Sareban M, Engelhardt H, Eitel I, Gutberlet M, Schuler G, Circulation 2009 120 Suppl 300
70. Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. Sorensson P, Heiberg E, Saleh N, Bouvier F, Caidahl K, Tornvall P, et al. J Cardiovasc Magn Reson 2010 12 25 10.1186/1532-429X-12-25 20433716
71. Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction. Berry C, Kellman P, Mancini C, Chen MY, Bandettini WP, Lowrey T, et al. Circ Cardiovasc Imaging 2010 3 527 535 10.1161/CIRCIMAGING.109.900761 20631034
72. Experimental infarct size as a function of the amount of myocardium at risk. Lowe JE, Reimer KA, Jennings RB, Am J Pathol 1978 90 363 379 623206
73. Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models. Reimer KA, Jennings RB, Cobb FR, Murdock RH, Greenfield JC Jr, Becker LC, et al. Circ Res 1985 56 651 665 3838923 (Pubitemid 15093376)
74. High-dose N-Acetylcystein versus placebo to prevent contrast-induced nephropathy and myocardial reperfusion injury in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fürnau G, et al. J Am Coll Cardiol 55 2201 2209 10.1016/j.jacc.2009.08.091 20466200
75. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Lonborg J, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, et al. Circ Cardiovasc Interv 2010 3 34 41 10.1161/CIRCINTERVENTIONS.109. 905521 20118154
76. Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Ganame J, Messalli G, Dymarkowski S, Rademakers FE, Desmet W, Van de Werf F, et al. Eur Heart J 2009 30 1440 1449 10.1093/eurheartj/ehp093 19346229
77. Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention. Beek AM, Nijveldt R, van Rossum AC, Int J Cardiovasc Imaging 2010 26 49 55 10.1007/s10554-009-9499-1 19757151
78. Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging. Bekkers SC, Backes WH, Kim RJ, Snoep G, Gorgels AP, Passos VL, et al. Eur Radiol 2009 19 2904 2912 10.1007/s00330-009-1489-0
79. Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk. Mather AN, Fairbairn TA, Ball SG, Greenwood JP, Plein S, Heart 2010 21051455
80. Assessment of postreperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T. Lotan CS, Bouchard A, Cranney GB, Bishop SP, Pohost GM, Circulation 1992 86 1018 1025 1516171
81. Hemorrhage in the myocardium following infarction. Cannan C, Eitel I, Hare J, Kumar A, Friedrich M, JACC Cardiovasc Imaging 2010 3 665 668 10.1016/j.jcmg.2009.12.019 20541722
82. Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging. Ortiz-Perez JT, Meyers SN, Lee DC, Kansal P, Klocke FJ, Holly TA, et al. Eur Heart J 2007 28 1750 1758 10.1093/eurheartj/ehm212 17586811 (Pubitemid 47227100)
83. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB, Circulation 1977 56 786 794 912839 (Pubitemid 8235183)
84. Aborted myocardial infarction: a new target for reperfusion therapy. Verheugt FW, Gersh BJ, Armstrong PW, Eur Heart J 2006 27 901 904 10.1093/eurheartj/ehi829 16543251
85. Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection. Ubachs JF, Engblom H, Erlinge D, Jovinge S, Hedstrom E, Carlsson M, et al. J Cardiovasc Magn Reson 2010 12 18 10.1186/1532-429X-12-18 20350309
86. A simple MR algorithm for estimation of myocardial salvage following acute ST segment elevation myocardial infarction. Jensen CJ, Bleckmann D, Eberle HC, Nassenstein K, Schlosser T, Sabin GV, et al. Clin Res Cardiol 2009 98 651 656 10.1007/s00392-009-0051-z 19685002
87. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Braunwald E, Kloner RA, Circulation 1982 66 1146 1149 6754130 (Pubitemid 13238825)
88. Cardiac magnetic resonance measurements of area at risk and infarct size in ischemic syndromes. Klocke FJ, J Am Coll Cardiol 2010 55 2489 2490 10.1016/j.jacc.2010.01.048 20510216