Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits

Circulation Journal

Volumn 71, Issue 10, 2007, Pages 1622-1628

  Bao, Narentuoya ^a   Minatoguchi, Shinya ^a   Kobayashi, Hiroyuki ^a   Yasuda, Shinji ^a   Kawamura, Itta ^a   Iwasa, Masamitsu ^a   Yamaki, Takahiko ^a   Sumi, Syohei ^a   Misao, Yu ^a   Arai, Masazumi ^a   Nishigaki, Kazuhiko ^a   Takemura, Genzou ^a   Fujiwara, Takako ^b   Fujiwara, Hisayoshi ^a  

^a GIFU UNIVERSITY   (Japan)

^b KYOTO WOMEN'S UNIVERSITY   (Japan)

Author keywords

Infarct size; Mitochondrial KATP channel; Nitric oxide; Pravastatin; Protein kinase C

Indexed keywords

5 HYDROXYDECANOIC ACID; CHELERYTHRINE; GENTISIC ACID; HYDROETHIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYGEN RADICAL; POTASSIUM CHANNEL; PRAVASTATIN; PROTEIN KINASE C; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SODIUM CHLORIDE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; HEMODYNAMIC PARAMETERS; NONHUMAN; RABBIT; STAINING;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; KATP CHANNELS; MALE; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; NITRIC OXIDE; PRAVASTATIN; PROTEIN KINASE C; RABBITS; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 34948856003     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.71.1622     Document Type: Article

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