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Volumn 11, Issue 8, 2013, Pages 2814-2828

Evolution and distribution of saxitoxin biosynthesis in dinoflagellates

Author keywords

Cyanobacteria; Dinoflagellates; Harmful algal blooms (HABs); Horizontal gene transfer (HGT); Paralytic shellfish poisoning (PSP); Paralytic shellfish toxin (PST); Phylogeny; Saxitoxin; STX

Indexed keywords

MESSENGER RNA; NEUROTOXIN; SAXITOXIN;

EID: 84883780890     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11082814     Document Type: Review
Times cited : (57)

References (60)
  • 2
    • 0027838126 scopus 로고
    • A review of harmful algal blooms and their apparent global increase
    • Hallegraeff, G.M. A review of harmful algal blooms and their apparent global increase. Phycologia 1993, 32, 79-99.
    • (1993) Phycologia , vol.32 , pp. 79-99
    • Hallegraeff, G.M.1
  • 4
    • 0018574999 scopus 로고
    • Neurotoxin binding to receptor sites associated with voltage sensitive sodium channels in intact, lysed, and detergent solubilized brain membranes
    • Catterall, W.A.; Morrow, C.S.; Hartshorne, R.P. Neurotoxin binding to receptor sites associated with voltage sensitive sodium channels in intact, lysed, and detergent solubilized brain membranes. J. Biol. Chem. 1979, 254, 1379-1387.
    • (1979) J. Biol. Chem. , vol.254 , pp. 1379-1387
    • Catterall, W.A.1    Morrow, C.S.2    Hartshorne, R.P.3
  • 5
    • 33645393913 scopus 로고    scopus 로고
    • Saxitoxin a toxic marine natural product that targets a multitude of receptors
    • Llewellyn, L.E. Saxitoxin, a toxic marine natural product that targets a multitude of receptors. Nat. Prod. Rep. 2006, 23, 200-222.
    • (2006) Nat. Prod. Rep. , vol.23 , pp. 200-222
    • Llewellyn, L.E.1
  • 6
    • 0002961340 scopus 로고
    • Harmful algal blooms: A global overview
    • Hallegraeff, G.M., Anderson, D.M., Cembella, A.D., Eds.; International Oceanographic Commission (IOC) Manual and Guides UNESCO: Paris, France
    • Hallegraeff, G.M. Harmful Algal Blooms: A Global Overview. In Manual of Harmful Marine Microalgae; Hallegraeff, G.M., Anderson, D.M., Cembella, A.D., Eds.; International Oceanographic Commission (IOC) Manual and Guides UNESCO: Paris, France, 1995; pp. 1-22.
    • (1995) Manual of Harmful Marine Microalgae , pp. 1-22
    • Hallegraeff, G.M.1
  • 7
    • 41649093625 scopus 로고    scopus 로고
    • The economic effects of harmful algal blooms
    • Graneli, E., Turner, T., Eds.; Springer-Verlag: Dordrecht, The Netherlands
    • Hoagland, P.; Scatasta, S. The Economic Effects of Harmful Algal Blooms. In Ecology of Harmful Algae; Graneli, E., Turner, T., Eds.; Springer-Verlag: Dordrecht, The Netherlands, 2006; pp. 391-402.
    • (2006) Ecology of Harmful Algae , pp. 391-402
    • Hoagland, P.1    Scatasta, S.2
  • 10
    • 84856113033 scopus 로고    scopus 로고
    • Biology ecology and bloom dynamics of the toxic marine dinoflagellate Pyrodinium bahamense
    • Usup, G.; Ahmad, A.; Matsuoka, K.; Lim, P.T.; Leaw, C.P. Biology, ecology and bloom dynamics of the toxic marine dinoflagellate Pyrodinium bahamense. Harmful Algae 2012, 14, 301-312.
    • (2012) Harmful Algae , vol.14 , pp. 301-312
    • Usup, G.1    Ahmad, A.2    Matsuoka, K.3    Lim, P.T.4    Leaw, C.P.5
  • 12
    • 6344271329 scopus 로고    scopus 로고
    • Harmful algal blooms: A global overview
    • Hallegraeff, G.M., Anderson, D.M., Cembella, A.D., Eds.; Imprimerie Landais: Paris, France
    • Hallegraeff, G.M. Harmful Algal Blooms: A Global Overview. In Manual on Harmful Marine Microalgae; Hallegraeff, G.M., Anderson, D.M., Cembella, A.D., Eds.; Imprimerie Landais: Paris, France, 2005; pp. 25-49.
    • (2005) Manual on Harmful Marine Microalgae , pp. 25-49
    • Hallegraeff, G.M.1
  • 13
    • 0001565275 scopus 로고    scopus 로고
    • Ecophysiology and metabolism of paralytic shellfish toxins in marine microalgae
    • Anderson, D.M., Cembella, A.D., Hallegraeff, G.M., Eds.; Springer: Berlin, Germany
    • Cembella, A.D. Ecophysiology and Metabolism of Paralytic Shellfish Toxins in Marine Microalgae. In Physiological Ecology of Harmful Algal Blooms; Anderson, D.M., Cembella, A.D., Hallegraeff, G.M., Eds.; Springer: Berlin, Germany, 1998; pp. 381-403.
    • (1998) Physiological Ecology of Harmful Algal Blooms , pp. 381-403
    • Cembella, A.D.1
  • 14
    • 77950944296 scopus 로고    scopus 로고
    • Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum
    • doi:10.1186/1471-2164-11-248
    • Yang, I.; John, U.; Beszteri, S.; Glockner, G.; Krock, B.; Goesmann, A.; Cembella, A.D. Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics 2010, 11, doi:10.1186/1471-2164-11-248.
    • (2010) BMC Genomics , pp. 11
    • Yang, I.1    John, U.2    Beszteri, S.3    Glockner, G.4    Krock, B.5    Goesmann, A.6    Cembella, A.D.7
  • 15
    • 80052971520 scopus 로고    scopus 로고
    • Improved phylogenetic resolution of toxic and non-toxic Alexandrium strains using a concatenated rDNA approach
    • Orr, R.J.S.; Stüken, A.; Rundberget, T.; Eikrem, W.; Jakobsen, K.S. Improved phylogenetic resolution of toxic and non-toxic Alexandrium strains using a concatenated rDNA approach. Harmful Algae 2011, 10, 676-688.
    • (2011) Harmful Algae , vol.10 , pp. 676-688
    • Orr, R.J.S.1    Stüken, A.2    Rundberget, T.3    Eikrem, W.4    Jakobsen, K.S.5
  • 16
    • 79951831891 scopus 로고    scopus 로고
    • Extraordinary conservation, gene loss, and positive selection in the evolution of an ancient neurotoxin
    • Murray, S.A.; Mihali, T.K.; Neilan, B.A. Extraordinary conservation, gene loss, and positive selection in the evolution of an ancient neurotoxin. Mol. Biol. Evol. 2011, 28, 1173-1182.
    • (2011) Mol. Biol. Evol. , vol.28 , pp. 1173-1182
    • Murray, S.A.1    Mihali, T.K.2    Neilan, B.A.3
  • 17
    • 0023900006 scopus 로고
    • Bacterial production of saxitoxin
    • Kodama, M.; Ogata, T.; Sato, S. Bacterial production of saxitoxin. Agric. Biol. Chem. 1988, 52, 1075-1077.
    • (1988) Agric. Biol. Chem. , vol.52 , pp. 1075-1077
    • Kodama, M.1    Ogata, T.2    Sato, S.3
  • 18
    • 0035686054 scopus 로고    scopus 로고
    • Purification of an enzyme involved in saxitoxin synthesis
    • Plumley, F.G. Purification of an enzyme involved in saxitoxin synthesis. J. Phycol. 2001, 37, 926-928.
    • (2001) J. Phycol. , vol.37 , pp. 926-928
    • Plumley, F.G.1
  • 19
    • 0000642932 scopus 로고    scopus 로고
    • The fosil record: Tracing the roots of the cyanobacterial lineage
    • Whitton, B.A., Potts, M., Eds.; Kluwer Academic Publishers: Dordrecht, The Netherlands
    • Schopf, J.W. The Fosil Record: Tracing the Roots of the Cyanobacterial Lineage. In The Ecology of Cyanobacteria: Their Diversity in Time and Space; Whitton, B.A., Potts, M., Eds.; Kluwer Academic Publishers: Dordrecht, The Netherlands, 2000; pp. 13-35.
    • (2000) The Ecology of Cyanobacteria: Their Diversity in Time and Space , pp. 13-35
    • Schopf, J.W.1
  • 21
    • 46949108154 scopus 로고    scopus 로고
    • Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria
    • Kellmann, R.; Mihali, T.K.; Jeon, Y.J.; Pickford, R.; Pomati, F.; Neilan, B.A. Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl. Environ. Microbiol. 2008, 74, 4044-4053.
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 4044-4053
    • Kellmann, R.1    Mihali, T.K.2    Jeon, Y.J.3    Pickford, R.4    Pomati, F.5    Neilan, B.A.6
  • 24
    • 77952572900 scopus 로고    scopus 로고
    • Biosynthesis and molecular genetics of polyketides in marine dinoflagellates
    • Kellmann, R.; Stüken, A.; Orr, R.J.S.; Svendsen, H.M.; Jakobsen, K.S. Biosynthesis and molecular genetics of polyketides in marine dinoflagellates. Mar. Drugs 2010, 8, 1011-1048.
    • (2010) Mar. Drugs , vol.8 , pp. 1011-1048
    • Kellmann, R.1    Stüken, A.2    Orr, R.J.S.3    Svendsen, H.M.4    Jakobsen, K.S.5
  • 25
    • 0029843191 scopus 로고    scopus 로고
    • Microalgal metabolites: A new perspective
    • Shimizu, Y. Microalgal metabolites: A new perspective. Annu. Rev. Microbiol. 1996, 50, 431-465.
    • (1996) Annu. Rev. Microbiol. , vol.50 , pp. 431-465
    • Shimizu, Y.1
  • 26
    • 33846232297 scopus 로고    scopus 로고
    • S-Adenosylmethionine synthetase genes from eleven marine dinoflagellates
    • Harlow, L.D.; Koutoulis, A.; Hallegraeff, G.M. S-Adenosylmethionine synthetase genes from eleven marine dinoflagellates. Phycologia 2007, 46, 46-53.
    • (2007) Phycologia , vol.46 , pp. 46-53
    • Harlow, L.D.1    Koutoulis, A.2    Hallegraeff, G.M.3
  • 28
    • 84875517957 scopus 로고    scopus 로고
    • Evolutionary acquisition and loss of saxitoxin biosynthesis in dinoflagellates: The second "core" gene - SxtG
    • Orr, R.J.S.; Stüken, A.; Murray, S.A.; Jakobsen, K.S. Evolutionary acquisition and loss of saxitoxin biosynthesis in dinoflagellates: The second "core" gene - sxtG. Appl. Environ. Microbiol. 2013, 79, 2128-2136.
    • (2013) Appl. Environ. Microbiol. , vol.79 , pp. 2128-2136
    • Orr, R.J.S.1    Stüken, A.2    Murray, S.A.3    Jakobsen, K.S.4
  • 29
    • 0025668592 scopus 로고
    • Intracellular bacteria: The origin of dinoflagellate toxicity
    • Silva, E.S. Intracellular bacteria: The origin of dinoflagellate toxicity. J. Environ. Pathol. Toxicol. 1990, 10, 124-128.
    • (1990) J. Environ. Pathol. Toxicol. , vol.10 , pp. 124-128
    • Silva, E.S.1
  • 30
    • 1542301478 scopus 로고    scopus 로고
    • Phylogenetic and functional diversity of the cultivable bacterial community associated with the paralytic shellfish poisoning dinoflagellate Gymnodinium catenatum
    • Green, D.H.; Llewellyn, L.E.; Negri, A.P.; Blackburn, S.I.; Bolch, C.J.S. Phylogenetic and functional diversity of the cultivable bacterial community associated with the paralytic shellfish poisoning dinoflagellate Gymnodinium catenatum. FEMS Microbiol. Ecol. 2004, 47, 345-357.
    • (2004) FEMS Microbiol. Ecol. , vol.47 , pp. 345-357
    • Green, D.H.1    Llewellyn, L.E.2    Negri, A.P.3    Blackburn, S.I.4    Bolch, C.J.S.5
  • 31
    • 3843112586 scopus 로고    scopus 로고
    • Bacterial diversity in toxic Alexandrium tamarense blooms off the Orkney Isles and the Firth of Forth
    • Wichels, A.; Hummert, C.; Elbrachter, M.; Luckas, B.; Schutt, C.; Gerdts, G. Bacterial diversity in toxic Alexandrium tamarense blooms off the Orkney Isles and the Firth of Forth. Helgol. Mar. Res. 2004, 58, 93-103.
    • (2004) Helgol. Mar. Res. , vol.58 , pp. 93-103
    • Wichels, A.1    Hummert, C.2    Elbrachter, M.3    Luckas, B.4    Schutt, C.5    Gerdts, G.6
  • 32
    • 0141481133 scopus 로고    scopus 로고
    • Reevaluation of production of paralytic shellfish toxin by bacteria associated with dinoflagellates of the Portuguese coast
    • Martins, C.A.; Alvito, P.; Tavares, M.J.; Pereira, P.; Doucette, G.; Franca, S. Reevaluation of production of paralytic shellfish toxin by bacteria associated with dinoflagellates of the Portuguese coast. Appl. Environ. Microbiol. 2003, 69, 5693-5698.
    • (2003) Appl. Environ. Microbiol. , vol.69 , pp. 5693-5698
    • Martins, C.A.1    Alvito, P.2    Tavares, M.J.3    Pereira, P.4    Doucette, G.5    Franca, S.6
  • 33
    • 0033679183 scopus 로고    scopus 로고
    • Isolation of bacteria from toxic dinoflagellate Alexandrium minutum and their effects on algae toxicity
    • Lu, Y.H.; Chai, T.J.; Hwang, D.F. Isolation of bacteria from toxic dinoflagellate Alexandrium minutum and their effects on algae toxicity. J. Nat. Toxins 2000, 9, 409-417.
    • (2000) J. Nat. Toxins , vol.9 , pp. 409-417
    • Lu, Y.H.1    Chai, T.J.2    Hwang, D.F.3
  • 34
    • 0037356998 scopus 로고    scopus 로고
    • GTX (4) imposters: Characterization of fluorescent compounds synthesized by Pseudomonas stutzeri SF/PS and Pseudomonas/Alteromonas PTB-1, symbionts of saxitoxin-producing Alexandrium spp
    • Baker, T.R.; Doucette, G.J.; Powell, C.L.; Boyer, G.L.; Plumley, F.G. GTX(4) imposters: Characterization of fluorescent compounds synthesized by Pseudomonas stutzeri SF/PS and Pseudomonas/Alteromonas PTB-1, symbionts of saxitoxin-producing Alexandrium spp. Toxicon 2003, 41, 339-347.
    • (2003) Toxicon , vol.41 , pp. 339-347
    • Baker, T.R.1    Doucette, G.J.2    Powell, C.L.3    Boyer, G.L.4    Plumley, F.G.5
  • 35
    • 0034943925 scopus 로고    scopus 로고
    • Comparison of paralytic shellfish toxin (PST) production by the dinoflagellates Alexandrium lusitanicum NEPCC 253 and Alexandrium tamarense NEPCC 407 in the presence and absence of bacteria
    • Hold, G.L.; Smith, E.A.; Birkbeck, T.H.; Gallacher, S. Comparison of paralytic shellfish toxin (PST) production by the dinoflagellates Alexandrium lusitanicum NEPCC 253 and Alexandrium tamarense NEPCC 407 in the presence and absence of bacteria. FEMS Microbiol. Ecol. 2001, 36, 223-234.
    • (2001) FEMS Microbiol. Ecol. , vol.36 , pp. 223-234
    • Hold, G.L.1    Smith, E.A.2    Birkbeck, T.H.3    Gallacher, S.4
  • 36
    • 33749632793 scopus 로고    scopus 로고
    • Phylogenetic diversity of bacteria associated with toxic and non-toxic strains of Alexandrium minutum
    • Palacios, L.; Reguera, B.; Franco, J.; Marin, I. Phylogenetic diversity of bacteria associated with toxic and non-toxic strains of Alexandrium minutum. Afr. J. Mar. Sci. 2006, 28, 409-414.
    • (2006) Afr. J. Mar. Sci. , vol.28 , pp. 409-414
    • Palacios, L.1    Reguera, B.2    Franco, J.3    Marin, I.4
  • 37
    • 0033779923 scopus 로고    scopus 로고
    • Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective
    • Pichersky, E.; Gang, D.R. Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective. Trends Plant Sci. 2000, 5, 439-445.
    • (2000) Trends Plant Sci. , vol.5 , pp. 439-445
    • Pichersky, E.1    Gang, D.R.2
  • 38
    • 67650297002 scopus 로고    scopus 로고
    • Cascades of convergent evolution: The corresponding evolutionary histories of euglenozoans and dinoflagellates
    • Lukes, J.; Leander, B.S.; Keeling, P.J. Cascades of convergent evolution: The corresponding evolutionary histories of euglenozoans and dinoflagellates. Proc. Natl. Acad. Sci. USA 2009, 106, 9963-9970.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9963-9970
    • Lukes, J.1    Leander, B.S.2    Keeling, P.J.3
  • 39
    • 17544367678 scopus 로고    scopus 로고
    • Convergent evolution of domain architectures (is rare)
    • Gough, J. Convergent evolution of domain architectures (is rare). Bioinformatics 2005, 21, 1464-1471.
    • (2005) Bioinformatics , vol.21 , pp. 1464-1471
    • Gough, J.1
  • 40
    • 44649109665 scopus 로고    scopus 로고
    • Toxin-resistant sodium channels: Parallel adaptive evolution across a complete gene family
    • Jost, M.C.; Hillis, D.M.; Lu, Y.; Kyle, J.W.; Fozzard, H.A.; Zakon, H.H. Toxin-resistant sodium channels: Parallel adaptive evolution across a complete gene family. Mol. Biol. Evol. 2008, 25, 1016-1024.
    • (2008) Mol. Biol. Evol. , vol.25 , pp. 1016-1024
    • Jost, M.C.1    Hillis, D.M.2    Lu, Y.3    Kyle, J.W.4    Fozzard, H.A.5    Zakon, H.H.6
  • 41
    • 0034163439 scopus 로고    scopus 로고
    • Horizontal gene transfer and the origin of species: Lessons from bacteria
    • De la Cruz, F.; Davies, J. Horizontal gene transfer and the origin of species: Lessons from bacteria. Trends Microbiol. 2000, 8, 128-133.
    • (2000) Trends Microbiol. , vol.8 , pp. 128-133
    • De La Cruz, F.1    Davies, J.2
  • 42
    • 47649104484 scopus 로고    scopus 로고
    • Horizontal gene transfer in eukaryotic evolution
    • Keeling, P.J.; Palmer, J.D. Horizontal gene transfer in eukaryotic evolution. Nat. Rev. Genet. 2008, 9, 605-618.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 605-618
    • Keeling, P.J.1    Palmer, J.D.2
  • 44
    • 0028977898 scopus 로고
    • A nuclear-encoded form II RuBisCO in dinoflagellates
    • Morse, D.; Salois, P.; Markovic, P.; Hastings, J.W. A nuclear-encoded form II RuBisCO in dinoflagellates. Science 1995, 268, 1622-1624.
    • (1995) Science , vol.268 , pp. 1622-1624
    • Morse, D.1    Salois, P.2    Markovic, P.3    Hastings, J.W.4
  • 45
    • 0038143248 scopus 로고    scopus 로고
    • Histone-like proteins of the dinoflagellate Crypthecodinium cohnii have homologies to bacterial DNA-binding proteins
    • Wong, J.T.Y.; New, D.C.; Wong, J.C.W.; Hung, V.K.L. Histone-like proteins of the dinoflagellate Crypthecodinium cohnii have homologies to bacterial DNA-binding proteins. Eukaryot. Cell 2003, 2, 646-650.
    • (2003) Eukaryot. Cell , vol.2 , pp. 646-650
    • Wong, J.T.Y.1    New, D.C.2    Wong, J.C.W.3    Hung, V.K.L.4
  • 46
    • 84860477639 scopus 로고    scopus 로고
    • Bioinformatics evidence for the transfer of mycosporine-like amino acid core (4-deoxygadusol) synthesizing gene from cyanobacteria to dinoflagellates and an attempt to mutate the same gene (YP-324358) in Anabaena variabilis PCC 7937
    • Singh, S.P.; Hader, D.P.; Sinha, R.P. Bioinformatics evidence for the transfer of mycosporine-like amino acid core (4-deoxygadusol) synthesizing gene from cyanobacteria to dinoflagellates and an attempt to mutate the same gene (YP-324358) in Anabaena variabilis PCC 7937. Gene 2012, 500, 155-163.
    • (2012) Gene , vol.500 , pp. 155-163
    • Singh, S.P.1    Hader, D.P.2    Sinha, R.P.3
  • 47
    • 0000107825 scopus 로고
    • Relationship between dinoflagellates and intracellular bacteria
    • Silva, E.S. Relationship between dinoflagellates and intracellular bacteria. Mar. Algae Pharmacol. Sci. 1982, 2, 269-288.
    • (1982) Mar. Algae Pharmacol. Sci. , vol.2 , pp. 269-288
    • Silva, E.S.1
  • 49
    • 77955405103 scopus 로고    scopus 로고
    • The cylindrospermopsin gene cluster of Aphanizomenon sp strain 10E6: Organization and recombination
    • Stüken, A.; Jakobsen, K.S. The cylindrospermopsin gene cluster of Aphanizomenon sp. strain 10E6: Organization and recombination. Microbiology 2010, 156, 2438-2451.
    • (2010) Microbiology , vol.156 , pp. 2438-2451
    • Stüken, A.1    Jakobsen, K.S.2
  • 50
    • 84861416517 scopus 로고    scopus 로고
    • Dozens of toxin-related genes are expressed in a nontoxic strain of the dinoflagellate Heterocapsa circularisquama
    • Salcedo, T.; Upadhyay, R.J.; Nagasaki, K.; Bhattacharya, D. Dozens of toxin-related genes are expressed in a nontoxic strain of the dinoflagellate Heterocapsa circularisquama. Mol. Biol. Evol. 2012, 29, 1503-1506.
    • (2012) Mol. Biol. Evol. , vol.29 , pp. 1503-1506
    • Salcedo, T.1    Upadhyay, R.J.2    Nagasaki, K.3    Bhattacharya, D.4
  • 51
    • 84869763820 scopus 로고    scopus 로고
    • When naked became armored: An eight-gene phylogeny reveals monophyletic origin of theca in dinoflagellates
    • Orr, R.J.S.; Murray, S.; Stüken, A.; Rhodes, L.; Jakobsen, K.S. When naked became armored: An eight-gene phylogeny reveals monophyletic origin of theca in dinoflagellates. PLoS One 2012, 7, e50004.
    • (2012) PLoS One , vol.7
    • Orr, R.J.S.1    Murray, S.2    Stüken, A.3    Rhodes, L.4    Jakobsen, K.S.5
  • 52
    • 36849043022 scopus 로고    scopus 로고
    • Species boundaries and global biogeography of the Alexandrium tamarense complex (Dinophyceae)
    • Lilly, E.L.; Halanych, K.M.; Anderson, D.M. Species boundaries and global biogeography of the Alexandrium tamarense complex (Dinophyceae). J. Phycol. 2007, 43, 1329-1338.
    • (2007) J. Phycol. , vol.43 , pp. 1329-1338
    • Lilly, E.L.1    Halanych, K.M.2    Anderson, D.M.3
  • 53
    • 84861677290 scopus 로고    scopus 로고
    • A reinvestigation of saxitoxin production and sxta in the "non-toxic" Alexandrium tamarense Group v clade
    • Murray, S.A.; Wiese, M.; Neilan, B.A.; Orr, R.J.S.; de Salas, M.; Brett, S.; Hallegraeff, G. A reinvestigation of saxitoxin production and sxtA in the "non-toxic" Alexandrium tamarense Group V clade. Harmful Algae 2012, 18, 96-104.
    • (2012) Harmful Algae , vol.18 , pp. 96-104
    • Murray, S.A.1    Wiese, M.2    Neilan, B.A.3    Orr, R.J.S.4    De Salas, M.5    Brett, S.6    Hallegraeff, G.7
  • 55
    • 84878112333 scopus 로고    scopus 로고
    • Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex
    • Suikkanen, S.; Kremp, A.; Hautala, H.; Krock, B. Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex. Harmful Algae 2013, 26, 52-59.
    • (2013) Harmful Algae , vol.26 , pp. 52-59
    • Suikkanen, S.1    Kremp, A.2    Hautala, H.3    Krock, B.4
  • 57
    • 84866034179 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of differentially expressed proteins in the toxicity-lost mutant of Alexandrium catenella (Dinophyceae) in the exponential phase
    • Wang, D.-Z.; Li, C.; Zhang, Y.; Wang, Y.-Y.; He, Z.-P.; Lin, L.; Hong, H.-S. Quantitative proteomic analysis of differentially expressed proteins in the toxicity-lost mutant of Alexandrium catenella (Dinophyceae) in the exponential phase. J. Proteomics 2012, 75, 5564-5577.
    • (2012) J. Proteomics , vol.75 , pp. 5564-5577
    • Wang, D.-Z.1    Li, C.2    Zhang, Y.3    Wang, Y.-Y.4    He, Z.-P.5    Lin, L.6    Hong, H.-S.7
  • 58
    • 73349126460 scopus 로고    scopus 로고
    • Emergent gene order in a model of modular polyketide synthases
    • Callahan, B.; Thattai, M.; Shraiman, B.I. Emergent gene order in a model of modular polyketide synthases. Proc. Natl. Acad. Sci. USA 2009, 106, 19410-19415.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19410-19415
    • Callahan, B.1    Thattai, M.2    Shraiman, B.I.3
  • 59
    • 0034800552 scopus 로고    scopus 로고
    • Biosynthesis of natural products on modular peptide synthetases
    • Doekel, S.; Marahiel, M.A. Biosynthesis of natural products on modular peptide synthetases. Metab. Eng. 2001, 3, 64-77.
    • (2001) Metab. Eng. , vol.3 , pp. 64-77
    • Doekel, S.1    Marahiel, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.