Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: Unique screening and Oncostatin M-like activity

Differentiation

Volumn 86, Issue 1-2, 2013, Pages 65-74

  Nawa, Katsuhiko ^a   Ikeno, Hirotaka ^a   Matsuhashi, Norikazu ^a   Ogasawara, Tomomi ^a   Otsuka, Eri ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Adipogenesis; Isoxazole; Mesenchymal stem cell; Oncostatin M; Osteogenesis

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CYTOKINE; INTERLEUKIN 11; INTERLEUKIN 6; ISOXAZOLE DERIVATIVE; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; WNT PROTEIN;

ADIPOGENESIS; ADIPOGENESIS INHIBITION; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL DIFFERENTIATION; CELL LEVEL; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE INDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LIPID STORAGE; MESENCHYMAL STEM CELL; OSTEOBLAST; OSTEOBLASTOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE;

ADIPOGENESIS; ALKALINE PHOSPHATASE; ALP; C/EBP; CCAAT/ENHANCER-BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE; GSK; IL-11; IL-6; INTERLEUKIN-11; INTERLEUKIN-6; ISOXAZOLE; LEF; LEUKEMIA INHIBITORY FACTOR; LIF; LYMPHOID ENHANCER FACTOR; MESENCHYMAL STEM CELL; MSC; ONCOSTATIN M; OSM; OSTEOGENESIS; OSTERIX; OSX; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PPAR; RUNT-RELATED TRANSCRIPTION FACTOR; RUNX; T-CELL FACTOR; TCF;

ADIPOGENESIS; ALKALINE PHOSPHATASE; BETA CATENIN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOXAZOLES; MESENCHYMAL STROMAL CELLS; ONCOSTATIN M; OSTEOBLASTS; OSTEOGENESIS; PPAR GAMMA; SMALL MOLECULE LIBRARIES; TRANSCRIPTION FACTORS;

EID: 84883778841     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2013.07.005     Document Type: Article

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