Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post-weaning high multivitamin or high folate diet

International Journal of Obesity

Volumn 37, Issue 9, 2013, Pages 1177-1182

  Cho, C E ^a   Sanchez Hernandez D ^a   Reza Lopez S A ^a   Huot, P S P ^a   Kim, Y I ^a,b,c   Anderson, G H ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Folate; food intake regulation; gestational vitamins; hypothalamus; post weaning diet

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 5 RECEPTOR; FOLIC ACID; INSULIN RECEPTOR; LEPTIN RECEPTOR; MULTIVITAMIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CONTROLLED STUDY; DNA METHYLATION; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPOTHALAMUS; MALE; MATERNAL NUTRITION; NEWBORN; NONHUMAN; OBESITY; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RAT; VITAMIN SUPPLEMENTATION; WEIGHT GAIN;

RATTUS NORVEGICUS;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; EATING; FEEDING BEHAVIOR; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPOTHALAMUS; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; METABOLIC SYNDROME X; OBESITY; PHENOTYPE; PRO-OPIOMELANOCORTIN; RATS; RATS, WISTAR; RECEPTOR, INSULIN; RECEPTORS, DOPAMINE; RECEPTORS, LEPTIN; RECEPTORS, SEROTONIN; VITAMINS; WEANING;

EID: 84883746740     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.210     Document Type: Article

References (37)

1. Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993; 341: 938-941. (Pubitemid 23109122)
2. Hales CN, Barker DJ. Type 2 (non-Insulin-Dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia 1992; 35: 595-601.
3. Fall CH, Yajnik CS, Rao S, Davies AA, Brown N, Farrant HJ. Micronutrients and fetal growth. J Nutr 2003; 133(Suppl 2): 1747S-1756S. (Pubitemid 36548685)
4. Szeto IM, Aziz A, Das PJ, Taha AY, Okubo N, Reza-Lopez S et al. High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring. Am J Physiol Regul Integr Comp Physiol 2008; 295: R575-R582.
5. Szeto IM, Das PJ, Aziz A, Anderson GH. Multivitamin supplementation of Wistar rats during pregnancy accelerates the development of obesity in offspring fed an obesogenic diet. Int J Obes 2009; 33: 364-372.
6. Berthoud HR. Mind versus metabolism in the control of food intake and energy balance. Physiol Behav 2004; 81: 781-793.
7. Cripps RL, Martin-Gronert MS, Ozanne SE. Fetal and perinatal programming of appetite. Clin Sci 2005; 109: 1-11. (Pubitemid 40943028)
8. McMillen IC, Adam CL, Muhlhausler BS. Early origins of obesity: Programming the appetite regulatory system. J Physiol 2005; 565(Pt 1): 9-17. (Pubitemid 40723686)
9. Gluckman PD, Hanson MA. Living with the past: Evolution, development, and patterns of disease. Science 2004; 305: 1733-1736. (Pubitemid 39249632)
10. Gluckman PD, Hanson MA, Spencer HG. Predictive adaptive responses and human evolution. Trends Ecol Evol 2005; 20: 527-533. (Pubitemid 41323708)
11. Dominguez-Salas P, Cox SE, Prentice AM, Hennig BJ, Moore SE. Maternal nutritional status, C(1) metabolism and offspring DNA methylation: A review of current evidence in human subjects. Proc Nutr Soc 2012; 71: 154-165.
12. Kim YI. Nutritional epigenetics: Impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr 2005; 135: 2703-2709.
13. Reeves PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 1997; 127: 838S-841S. (Pubitemid 27209452)
14. Glowinski J, Iversen LL. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 1966; 13: 655-669.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-Time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408. (Pubitemid 34164012)
16. Molloy AM, Scott JM. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 1997; 281: 43-53. (Pubitemid 27362441)
17. Sie KK, Chen J, Sohn KJ, Croxford R, Thompson LU, Kim YI. Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspring. Cancer Lett 2009; 280: 72-77.
18. Kotsopoulos J, Medline A, Renlund R, Sohn KJ, Martin R, Hwang SW et al. Effects of dietary folate on the development and progression of mammary tumors in rats. Carcinogenesis 2005; 26: 1603-1612. (Pubitemid 41236054)
19. Kotsopoulos J, Sohn KJ, Martin R, Choi M, Renlund R, McKerlie C et al. Dietary folate deficiency suppresses N-Methyl-N-Nitrosourea-Induced mammary tumorigenesis in rats. Carcinogenesis 2003; 24: 937-944. (Pubitemid 36748911)
20. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385: 165-168. (Pubitemid 27034218)
21. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR et al. Brain-Derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736-742. (Pubitemid 36792889)
22. Muhlhausler BS, Adam CL, McMillen IC. Maternal nutrition and the programming of obesity: The brain. Organogenesis 2008; 4: 144-152.
23. Muhlhausler BS, Adam CL, Findlay PA, Duffield JA, McMillen IC. Increased maternal nutrition alters development of the appetite-Regulating network in the brain. FASEB J 2006; 20: 1257-1259.
24. Baskin DG, Wilcox BJ, Figlewicz DP, Dorsa DM. Insulin and insulin-Like growth factors in the CNS. Trends Neurosci 1988; 11: 107-111. (Pubitemid 18053669)
25. Baskin DG, Breininger JF, Schwartz MW. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 1999; 48: 828-833. (Pubitemid 29153083)
26. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138: 4489-4492. (Pubitemid 27408500)
27. Meguid MM, Yang ZJ, Laviano A. Meal size and number: Relationship to dopamine levels in the ventromedial hypothalamic nucleus. Am J Physiol 1997; 272(Pt 2): R1925-R1930.
28. Meguid MM, Yang ZJ, Koseki M. Eating induced rise in LHA-Dopamine correlates with meal size in normal and bulbectomized rats. Brain Res Bull 1995; 36: 487-490.
29. Page KC, Malik RE, Ripple JA, Anday EK. Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-Fat diet in male offspring. Am J Physiol Regul Integr Comp Physiol 2009; 297: R1049-R1057.
30. Pelleymounter MA, Cullen MJ, Wellman CL. Characteristics of BDNF-Induced weight loss. Exp Neurol 1995; 131: 229-238.
31. Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH et al. Brainderived neurotrophic factor-Deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci USA 1999; 96: 15239-15244. (Pubitemid 30019796)
32. Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19: 1290-1300. (Pubitemid 30151025)
33. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 2010; 143: 1084-1096.
34. Mehedint MG, Niculescu MD, Craciunescu CN, Zeisel SH. Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin gene. FASEB J 2010; 24: 184-195.
35. Niculescu MD, Craciunescu CN, Zeisel SH. Dietary choline deficiency alters global and gene-Specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 2006; 20: 43-49. (Pubitemid 43100474)
36. Van Wijk N, Watkins CJ, Bohlke M, Maher TJ, Hageman RJ, Kamphuis PJ et al. Plasma choline concentration varies with different dietary levels of vitamins B6, B12 and folic acid in rats maintained on choline-Adequate diets. Br J Nutr 2012; 107: 1408-1412.
37. Vucetic Z, Kimmel J, Reyes TM. Chronic high-Fat diet drives postnatal epigenetic regulation of mu-Opioid receptor in the brain. Neuropsychopharmacology 2011; 36: 1199-1206.