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Volumn 289, Issue , 2008, Pages 180-188

Impact of Genetic Variant BDNF (Val66Met) on Brain Structure and Function

Author keywords

Downstream functional change; Gene environment interaction; Hippocampal anatomy and hippocampal dependent learning; Reliable genetic or non genetic biomarkers; Single nucleotide polymorphism (SNP)

Indexed keywords


EID: 84883744473     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470751251.ch14     Document Type: Chapter
Times cited : (42)

References (44)
  • 2
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: a convergence point for many signalling pathways
    • Chao MV 2003 Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 3
    • 32644451922 scopus 로고    scopus 로고
    • Neurotrophin signalling in health and disease
    • Chao MV, Rajagopal R, Lee FS 2006 Neurotrophin signalling in health and disease. Clin Sci (Lond) 110:167-173.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 167-173
    • Chao, M.V.1    Rajagopal, R.2    Lee, F.S.3
  • 4
    • 2342550552 scopus 로고    scopus 로고
    • Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    • Chen ZY, Patel PD, Sant G et al 2004 Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24:4401-4411.
    • (2004) J Neurosci , vol.24 , pp. 4401-4411
    • Chen, Z.Y.1    Patel, P.D.2    Sant, G.3
  • 5
    • 21544461501 scopus 로고    scopus 로고
    • Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    • Chen ZY, Ieraci A, Teng H et al 2005 Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci 25:6156-6166.
    • (2005) J Neurosci , vol.25 , pp. 6156-6166
    • Chen, Z.Y.1    Ieraci, A.2    Teng, H.3
  • 6
    • 33749649795 scopus 로고    scopus 로고
    • Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    • Chen ZY, Jing D, Bath KG et al 2006 Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140-143.
    • (2006) Science , vol.314 , pp. 140-143
    • Chen, Z.Y.1    Jing, D.2    Bath, K.G.3
  • 7
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley S, Paterson H, Kemp P, Marshall CJ 1994 Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 8
    • 0032854908 scopus 로고    scopus 로고
    • BDNF regulates the intrinsic excitability of cortical neurons
    • Desai N, Rutherford L, Turrigiano G 1999 BDNF regulates the intrinsic excitability of cortical neurons. Learn Mem 6:284-291.
    • (1999) Learn Mem , vol.6 , pp. 284-291
    • Desai, N.1    Rutherford, L.2    Turrigiano, G.3
  • 9
    • 0037462449 scopus 로고    scopus 로고
    • The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan MF, Kojima M, Callicott JH et al 2003 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269.
    • (2003) Cell , vol.112 , pp. 257-269
    • Egan, M.F.1    Kojima, M.2    Callicott, J.H.3
  • 10
    • 0034212624 scopus 로고    scopus 로고
    • Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor
    • Farhadi H, Mowla S, Petrecca K, Morris S, Seidah N, Murphy R 2000 Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. J Neurosci 20:4059-4068.
    • (2000) J Neurosci , vol.20 , pp. 4059-4068
    • Farhadi, H.1    Mowla, S.2    Petrecca, K.3    Morris, S.4    Seidah, N.5    Murphy, R.6
  • 11
    • 34147130914 scopus 로고    scopus 로고
    • Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    • Frodl T, Schule C, Schmitt G et al 2007 Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 64:410-416.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 410-416
    • Frodl, T.1    Schule, C.2    Schmitt, G.3
  • 12
    • 0032124328 scopus 로고    scopus 로고
    • Images of medial temporal lobe functions in human learning and memory
    • Gabrieli JD, Brewer JB, Poldrack RA 1998 Images of medial temporal lobe functions in human learning and memory. Neurobiol Learn Mem 70:275-283.
    • (1998) Neurobiol Learn Mem , vol.70 , pp. 275-283
    • Gabrieli, J.D.1    Brewer, J.B.2    Poldrack, R.A.3
  • 13
    • 33947235663 scopus 로고    scopus 로고
    • Brainderived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of casecontrol studies confirm association to substance-related disorders, eating disorders, and schizophrenia
    • Gratacos M, Gonzalez JR, Mercader JM, Cid RD, Urretavizcaya M, Estivill X 2007 Brainderived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of casecontrol studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 61:911-922.
    • (2007) Biol Psychiatry , vol.61 , pp. 911-922
    • Gratacos, M.1    Gonzalez, J.R.2    Mercader, J.M.3    Cid, R.D.4    Urretavizcaya, M.5    Estivill, X.6
  • 14
    • 0043135252 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    • Hariri AR, Goldberg TE, Mattay VS et al 2003 Brain-derived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23:6690-6694.
    • (2003) J Neurosci , vol.23 , pp. 6690-6694
    • Hariri, A.R.1    Goldberg, T.E.2    Mattay, V.S.3
  • 15
    • 33745698710 scopus 로고    scopus 로고
    • Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    • Ho BC, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH 2006 Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 63:731-740.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 731-740
    • Ho, B.C.1    Milev, P.2    O'Leary, D.S.3    Librant, A.4    Andreasen, N.C.5    Wassink, T.H.6
  • 16
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: roles in neuronal development and function
    • Huang E, Reichardt L 2001 Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.1    Reichardt, L.2
  • 17
    • 20544470482 scopus 로고    scopus 로고
    • BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
    • Jiang X, Xu K, Hoberman J et al 2005 BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30:1353-1361.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1353-1361
    • Jiang, X.1    Xu, K.2    Hoberman, J.3
  • 18
    • 33645337891 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
    • Kaufman J, Yang BZ, Douglas-Palumberi H et al 2006 Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 59:673-680.
    • (2006) Biol Psychiatry , vol.59 , pp. 673-680
    • Kaufman, J.1    Yang, B.Z.2    Douglas-Palumberi, H.3
  • 19
    • 40849134410 scopus 로고    scopus 로고
    • BDNF genotype potentially modifying the association between incident stroke and depression
    • press
    • Kim JM, Stewart R, Kim SW et al 2007 BDNF genotype potentially modifying the association between incident stroke and depression. Neurobiol Aging. In press.
    • (2007) Neurobiol Aging
    • Kim, J.M.1    Stewart, R.2    Kim, S.W.3
  • 20
    • 0029021177 scopus 로고
    • Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
    • Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T 1995 Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92:8856-8860.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8856-8860
    • Korte, M.1    Carroll, P.2    Wolf, E.3    Brem, G.4    Thoenen, H.5    Bonhoeffer, T.6
  • 21
    • 21244432717 scopus 로고    scopus 로고
    • Association of a functional BDNF polymorphism and anxiety-related personality traits
    • Lang UE, Hellweg R, Kalus P et al 2005 Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl) 180:95-99.
    • (2005) Psychopharmacology (Berl) , vol.180 , pp. 95-99
    • Lang, U.E.1    Hellweg, R.2    Kalus, P.3
  • 22
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee R, Kermani P, Teng KK, Hempstead BL 2001 Regulation of cell survival by secreted proneurotrophins. Science 294:1945-1948.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 23
    • 0037359267 scopus 로고    scopus 로고
    • BDNF and activity-dependent synaptic modulation
    • Lu B 2003a BDNF and activity-dependent synaptic modulation. Learn Mem 100:86-98.
    • (2003) Learn Mem , vol.100 , pp. 86-98
    • Lu, B.1
  • 24
    • 0041379342 scopus 로고    scopus 로고
    • Pro-region of neurotrophins: role in synaptic modulation
    • Lu B 2003b Pro-region of neurotrophins: role in synaptic modulation. Neuron 39:735-738.
    • (2003) Neuron , vol.39 , pp. 735-738
    • Lu, B.1
  • 25
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • Lu B, Pang PT, Woo NH 2005 The yin and yang of neurotrophin action. Nat Rev Neurosci 6:603-614.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 26
    • 18444381728 scopus 로고    scopus 로고
    • Knockout of Erk1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal mediated learning and memory
    • Mazzucchelli C, Vantaggiato C, Ciamei A et al 2002 Knockout of Erk1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal mediated learning and memory. Neuron 34:807-820.
    • (2002) Neuron , vol.34 , pp. 807-820
    • Mazzucchelli, C.1    Vantaggiato, C.2    Ciamei, A.3
  • 27
    • 0036135090 scopus 로고    scopus 로고
    • Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
    • Momose Y, Murata M, Kobayashi K et al 2002 Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms. Ann Neurol 51:133-136.
    • (2002) Ann Neurol , vol.51 , pp. 133-136
    • Momose, Y.1    Murata, M.2    Kobayashi, K.3
  • 28
    • 0036724341 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a familybased association study
    • Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy J 2002 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a familybased association study. Am J Hum Genet 71:651-655.
    • (2002) Am J Hum Genet , vol.71 , pp. 651-655
    • Neves-Pereira, M.1    Mundo, E.2    Muglia, P.3    King, N.4    Macciardi, F.5    Kennedy, J.6
  • 29
    • 5644251587 scopus 로고    scopus 로고
    • Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    • Pang PT, Teng HK, Zaitsev E et al 2004 Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306:487-491.
    • (2004) Science , vol.306 , pp. 487-491
    • Pang, P.T.1    Teng, H.K.2    Zaitsev, E.3
  • 30
    • 0030176079 scopus 로고    scopus 로고
    • Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    • Patterson S, Abel T, Deuel T, Martin K, Rose J, Kandel E 1996 Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145.
    • (1996) Neuron , vol.16 , pp. 1137-1145
    • Patterson, S.1    Abel, T.2    Deuel, T.3    Martin, K.4    Rose, J.5    Kandel, E.6
  • 31
    • 8544249878 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor Val66Met polymorphism and variation in human cortical morphology
    • Pezawas L, Verchinski BA, Mattay VS et al 2004 The brain-derived neurotrophic factor Val66Met polymorphism and variation in human cortical morphology. J Neurosci 24:10099-10102.
    • (2004) J Neurosci , vol.24 , pp. 10099-10102
    • Pezawas, L.1    Verchinski, B.A.2    Mattay, V.S.3
  • 32
    • 0026338953 scopus 로고
    • NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation
    • Qui M-S, Green SH 1991 NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron 7:937-946.
    • (1991) Neuron , vol.7 , pp. 937-946
    • Qui, M.-S.1    Green, S.H.2
  • 33
    • 0036662773 scopus 로고    scopus 로고
    • The role of extracellular regulated kinases I/II in late-phase long-term potentiation
    • Rosenblum K, Futter M, Voss K et al 2002 The role of extracellular regulated kinases I/II in late-phase long-term potentiation. J Neurosci 22:5432-5441.
    • (2002) J Neurosci , vol.22 , pp. 5432-5441
    • Rosenblum, K.1    Futter, M.2    Voss, K.3
  • 34
    • 0036344505 scopus 로고    scopus 로고
    • Neurotrophin signaling through the p75 neurotrophin receptor
    • Roux PP, Barker PA 2002 Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67:203-233.
    • (2002) Prog Neurobiol , vol.67 , pp. 203-233
    • Roux, P.P.1    Barker, P.A.2
  • 35
    • 0033520186 scopus 로고    scopus 로고
    • Perspectives: neuroscience. Remembrance of things past
    • Schacter DL, Wagner AD 1999 Perspectives: neuroscience. Remembrance of things past. Science 285:1503-1504.
    • (1999) Science , vol.285 , pp. 1503-1504
    • Schacter, D.L.1    Wagner, A.D.2
  • 37
    • 0037310231 scopus 로고    scopus 로고
    • A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression
    • Sen S, Nesse RM, Stoltenberg SF et al 2003 A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28:397-401.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 397-401
    • Sen, S.1    Nesse, R.M.2    Stoltenberg, S.F.3
  • 38
    • 1842486891 scopus 로고    scopus 로고
    • Ethnic difference of the BDNF 196G/A (Val66Met) polymorphism frequencies: the possibility to explain ethnic mental traits
    • Shimizu E, Hashimoto K, Iyo M 2004 Ethnic difference of the BDNF 196G/A (Val66Met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet 126:122-123.
    • (2004) Am J Med Genet B Neuropsychiatr Genet , vol.126 , pp. 122-123
    • Shimizu, E.1    Hashimoto, K.2    Iyo, M.3
  • 39
    • 0036347948 scopus 로고    scopus 로고
    • Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus
    • Sklar P, Gabriel S, McInnis M et al 2002 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol Psychiatry 7:579-593.
    • (2002) Mol Psychiatry , vol.7 , pp. 579-593
    • Sklar, P.1    Gabriel, S.2    McInnis, M.3
  • 40
    • 0025886159 scopus 로고
    • Two conserved domains in the NGF polypeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF
    • Suter U, Heymach J, Shooter E 1991 Two conserved domains in the NGF polypeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J 10:2394-2400.
    • (1991) EMBO J , vol.10 , pp. 2394-2400
    • Suter, U.1    Heymach, J.2    Shooter, E.3
  • 41
    • 21844458922 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met polymorphism and volume of the hippocampal formation
    • Szeszko PR, Lipsky R, Mentschel C et al 2005 Brain-derived neurotrophic factor Val66Met polymorphism and volume of the hippocampal formation. Mol Psychiatry 10:631-636.
    • (2005) Mol Psychiatry , vol.10 , pp. 631-636
    • Szeszko, P.R.1    Lipsky, R.2    Mentschel, C.3
  • 42
    • 20044370999 scopus 로고    scopus 로고
    • ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    • Teng HK, Teng KK, Lee R et al 2005 ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455-5463.
    • (2005) J Neurosci , vol.25 , pp. 5455-5463
    • Teng, H.K.1    Teng, K.K.2    Lee, R.3
  • 43
    • 0026486878 scopus 로고
    • Sustained activation of the mitogen-activated (MAP) kinase cascade may be required for differentiation of PC12 cells
    • Traverse S, Gomez N, Paterson H, Marshall C, Cohen P 1992 Sustained activation of the mitogen-activated (MAP) kinase cascade may be required for differentiation of PC12 cells. Biochem J 288:351-355.
    • (1992) Biochem J , vol.288 , pp. 351-355
    • Traverse, S.1    Gomez, N.2    Paterson, H.3    Marshall, C.4    Cohen, P.5
  • 44
    • 85047700298 scopus 로고    scopus 로고
    • Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease
    • Ventriglia M, Bocchio Chiavetto L, Benussi L et al 2002 Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 7:136-137.
    • (2002) Mol Psychiatry , vol.7 , pp. 136-137
    • Ventriglia, M.1    Bocchio Chiavetto, L.2    Benussi, L.3


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