Liver FOXP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation

Frontiers in Immunology

Volumn 4, Issue JUL, 2013, Pages

  Germanidis, Georgios ^a   Argentou, Nikoletta ^b   Hytiroglou, Prodromos ^a   Vassiliadis, Themistoklis ^a   Patsiaoura, Kalliopi ^c   Germenis, Anastasios E ^b   Speletas, Matthaios ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c Aristotle University of Thessaloniki   (Greece)

Author keywords

Chronic HBV hepatitis; FAS FASL; FOXP3; Inflammation; PD1 PDL1; Regulatory T cells

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADULT; AGED; APOPTOSIS; ARTICLE; BIOPSY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; FIBROSIS; HEPATITIS; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROLOGY; VIRUS LOAD;

EID: 84883730400     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00207     Document Type: Article

References (37)

1. Bertoletti A, Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut (2012) 61:1754-64. doi:10.1136/gutjnl-2011-301073
2. Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest (1997) 99:1472-7. doi:10.1172/JCI119308
3. Watanabe T, Bertoletti A, Tanoto TA. PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection. J Viral Hepat (2010) 17:453-8. doi:10.1111/j.1365-2893.2010.01313.x
4. Alatrakchi N, Koziel M. Regulatory T cells and viral liver disease. J Viral Hepat (2009) 16:223-9. doi:10.1111/j.1365-2893.2009.01081.x
5. Fisicaro P, Valdatta C, Massari M, Loggi E, Biasini E, Sacchelli L, et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology (2010) 138:682-93. doi:10.1053/j.gastro.2009.09.052
6. Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell (2010) 140:845-58. doi:10.1016/j.cell.2010.02.021
7. 3 in control of the regulatory T cell lineage. Nat Immunol (2007) 8:457-62. doi:10.1038/ni1455
8. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2007) 8: 191-7. doi:10.1038/ni1428
9. Lund JM, Hsing L, Pham TT, Rudensky AY. Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 320:1220-4. doi:10.1126/science.1155209
10. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology (2005) 41:771-8. doi:10.1002/hep.20649
11. 4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol (2005) 79:3322-8. doi:10.1128/JVI.79.6.3322-3328.2005
12. 4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infect Dis (2007) 7:804-13.
13. 4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol (2006) 177:739-47.
14. 3(+) T-cell subpopulation in chronic hepatitis B virus (HBV) infection: a highly informative strategy for distinguishing chronic HBV infection states. J Infect Dis (2012) 205:1111-20. doi:10.1093/infdis/jis011
15. Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, Tanaka J, et al. Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice. Gastroenterology (2011) 140:1322-33. doi:10.1053/j.gastro.2011.01.002
16. 3 expression in liver correlates with the degree but not the cause of inflammation.Mediators Inflamm (2011) 2011:827565. doi:10.1155/2011/827565
17. Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol (2004) 171:6322-7.
18. Ribeiro RM, Germanidis G, Powers KA, Pellegrin B, Nikolaidis P, Perelson AS, et al. Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections. J Infect Dis (2010) 202:1309-18. doi:10.1086/656528
19. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology (1981) 1:431-5. doi:10.1002/hep.1840010511
20. Ishak K, Baptista A, Bianchi L, Callea F, DeGroote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol (1995) 22:696-9. doi:10.1016/0168-8278(95)80226-6
21. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2T method. Methods (2001) 25:402-8. doi:10.1006/meth.2001.1262
22. Kassel R, Cruise MW, Iezzoni JC, Taylor NA, Pruett TL, Hahn YS. Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Hepatology (2009) 50: 1625-37. doi:10.1002/hep.23173
23. 4+CD25high regulatory T cells and programmed deathligand 1 in chronic hepatitis B. Viral Immunol (2012) 25:21-8. doi:10.1089/vim.2011.0049
24. Lee JY, Chae DW, Kim SM, Nam ES, Jang MK, Lee JH, et al. Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection. J Viral Hepat (2004) 33:130-5. doi:10.1046/j.1365-2893.2003.00486.x
25. Krammer PH. CD95's deadly mission in the immune system. Nature (2000) 407:789-95. doi:10.1038/35037728
26. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity (1995) 3:673-82. doi:10.1016/1074-7613(95)90057-8
27. Fulda S, Debatin KM. Modulation of TRAIL signaling for cancer therapy. Vitam Horm (2004) 67:275-90. doi:10.1016/S0083-6729(04)67015-4
28. Mundt B, Wirth T, Zender L, Waltemathe M, Trautwein C, Manns MP, et al. Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. Gut (2005) 54:1590-6. doi:10.1136/gut.2004.056929
29. Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science (1997) 277:818-21. doi:10.1126/science.277.5327.818
30. Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG. The novel receptor TRAIL-R4 induces NF-kB and protects against TRAILmediated apoptosis, yet retains an incomplete death domain. Immunity (1997) 7:813-20. doi:10.1016/S1074-7613(00)80399-4
31. Yao Q, Seol DW, Mi Z, Robbins PD. Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis. Arthritis Res Ther (2006) 8:R16. doi:10.1186/ar1867
32. 3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute, experimental hepatitis B virus infection. Hepatology (2012) 56:873-83. doi:10.1002/hep.25765
33. 3+ T regulatory cells correlates with progression of HBV infection. BMC Immunol (2012) 13:17. doi:10.1186/1471-2172-13-17
34. 3 expression in livers of chronic hepatitis B patients. BMC Immunol (2011) 12:25. doi:10.1186/1471-2172-12-25
35. 3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency. J Hepatol (2012) 57:125-32. doi:10.1016/j.jhep
36. Otano I, Suarez L, Dotor J, Gonzalez-Aparicio M, Crettaz J, Olagüe C, et al. Modulation of regulatory T cell activity in combination with IL-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B. Hepatology (2012) 56:474-83. doi:10.1002/hep.25667
37. Boni C, Laccabue D, Lampertico P, Giuberti T, Vigano M, Schivazappa S, et al. Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues. Gastroenterology (2012) 143:963-73. doi:10.1053/j.gastr