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Volumn 25, Issue 1, 2012, Pages 21-28

Inhibition of viral replication downregulates CD4 +CD25 high regulatory T cells and programmed death-ligand 1 in chronic hepatitis B

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 9; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TELBIVUDINE;

EID: 84863011093     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2011.0049     Document Type: Article
Times cited : (31)

References (35)
  • 2
    • 0033905185 scopus 로고    scopus 로고
    • Protection or damage: A dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?
    • DOI 10.1016/S1369-5274(00)00109-0
    • Bertoletti A, and Maini MK: Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection? Curr Opin Microbiol 2000 3 387-392. (Pubitemid 30640363)
    • (2000) Current Opinion in Microbiology , vol.3 , Issue.4 , pp. 387-392
    • Bertoletti, A.1    Maini, M.K.2
  • 4
    • 78651367729 scopus 로고    scopus 로고
    • Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
    • Chen J, Wang XM, Wu XJ, Wang Y, Zhao H, Shen B, and Wang GQ: Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B. Inflamm Res 2010;60:47-53.
    • (2010) Inflamm Res , vol.60 , pp. 47-53
    • Chen, J.1    Wang, X.M.2    Wu, X.J.3    Wang, Y.4    Zhao, H.5    Shen, B.6    Wang, G.Q.7
  • 5
    • 78651367729 scopus 로고    scopus 로고
    • Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
    • Chen J, Wang XM, Wu XJ, Wang Y, Zhao H, Shen B, and Wang GQ: Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B. Inflamm Res 2011;60:47-53.
    • (2011) Inflamm Res , vol.60 , pp. 47-53
    • Chen, J.1    Wang, X.M.2    Wu, X.J.3    Wang, Y.4    Zhao, H.5    Shen, B.6    Wang, G.Q.7
  • 6
    • 49149128080 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • Chen Z, Cheng Y, Xu Y, et al.: Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008;128:400-408.
    • (2008) Clin Immunol , vol.128 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3
  • 7
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • 693 e1-e4
    • Fisicaro P, Valdatta C, Massari M, et al.: Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology 2010;138:682-693, 693 e1-e4.
    • (2010) Gastroenterology , vol.138 , pp. 682-693
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3
  • 8
    • 14744271751 scopus 로고    scopus 로고
    • + regulatory T cells in patients with hepatitis B virus infection
    • DOI 10.1128/JVI.79.6.3322-3328.2005
    • Franzese O, Kennedy PT, Gehring AJ, Gotto J, Williams R, Maini MK, and Bertoletti A: Modulation of the CD8 + - T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis B virus infection. J Virol 2005;79: 3322-3328. (Pubitemid 40327921)
    • (2005) Journal of Virology , vol.79 , Issue.6 , pp. 3322-3328
    • Franzese, O.1    Kennedy, P.T.F.2    Gehring, A.J.3    Gotto, J.4    Williams, R.5    Maini, M.K.6    Bertoletti, A.7
  • 9
    • 34247194561 scopus 로고    scopus 로고
    • Management of hepatitis B: Summary of a clinical research workshop
    • DOI 10.1002/hep.21627
    • Hoofnagle JH, Doo E, Liang TJ, Fleischer R, and Lok AS: Management of hepatitis B: summary of a clinical research workshop. Hepatology 2007;45:1056-1075. (Pubitemid 46646501)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 1056-1075
    • Hoofnagle, J.H.1    Doo, E.2    Liang, T.J.3    Fleischer, R.4    Lok, A.S.F.5
  • 12
    • 70350112138 scopus 로고    scopus 로고
    • Correlation of circulating TLR2/4 expression with CD3+ /4 + /8 + T cells and Treg cells in HBV-related liver cirrhosis
    • Lian JQ, Wang XQ, Zhang Y, Huang CX, and Bai XF: Correlation of circulating TLR2/4 expression with CD3+ /4 + /8 + T cells and Treg cells in HBV-related liver cirrhosis. Viral Immunol 2009;22:301-308.
    • (2009) Viral Immunol , vol.22 , pp. 301-308
    • Lian, J.Q.1    Wang, X.Q.2    Zhang, Y.3    Huang, C.X.4    Bai, X.F.5
  • 13
    • 58649096155 scopus 로고    scopus 로고
    • 2-Year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B
    • Liaw YF, Gane E, Leung N, et al.: 2-Year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology 2009;136:486-495.
    • (2009) Gastroenterology , vol.136 , pp. 486-495
    • Liaw, Y.F.1    Gane, E.2    Leung, N.3
  • 14
    • 0035189597 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • DOI 10.1053/jhep.2001.29401
    • Lok AS, and McMahon BJ: Chronic hepatitis B. Hepatology 2001;34:1225-1241. (Pubitemid 33096596)
    • (2001) Hepatology , vol.34 , Issue.6 , pp. 1225-1241
    • Lok, A.S.F.1    McMahon, B.J.2
  • 15
    • 60649105085 scopus 로고    scopus 로고
    • Management of hepatitis B in China
    • Lu FM, and Zhuang H: Management of hepatitis B in China. Chin Med J (Engl) 2009;122:3-4.
    • (2009) Chin Med J (Engl) , vol.122 , pp. 3-4
    • Lu, F.M.1    Zhuang, H.2
  • 16
    • 33847406557 scopus 로고    scopus 로고
    • + T lymphocytes in the liver
    • Maier H, Isogawa M, Freeman GJ, and Chisari FV: PD-1:PDL1 interactions contribute to the functional suppression of virus-specific CD8 + T lymphocytes in the liver. J Immunol 2007;178:2714-2720. (Pubitemid 46333147)
    • (2007) Journal of Immunology , vol.178 , Issue.5 , pp. 2714-2720
    • Maier, H.1    Isogawa, M.2    Freeman, G.J.3    Chisari, F.V.4
  • 17
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: mechanisms of suppression
    • DOI 10.1016/j.molmed.2007.01.003, PII S1471491407000044
    • Miyara M, and Sakaguchi S: Natural regulatory T cells: mechanisms of suppression. TrendsMolMed 2007;13:108-116. (Pubitemid 46341958)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.3 , pp. 108-116
    • Miyara, M.1    Sakaguchi, S.2
  • 18
    • 76449096344 scopus 로고    scopus 로고
    • Circulating CD4 + CD25high regulatory T cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection
    • Nan XP, Zhang Y, Yu HT, Li Y, Sun RL, Wang JP, and Bai XF: Circulating CD4 + CD25high regulatory T cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection. Viral Immunol 2010;23: 63-70.
    • (2010) Viral Immunol , vol.23 , pp. 63-70
    • Nan, X.P.1    Zhang, Y.2    Yu, H.T.3    Li, Y.4    Sun, R.L.5    Wang, J.P.6    Bai, X.F.7
  • 19
    • 68149179251 scopus 로고    scopus 로고
    • IL-9 as a mediator of Th17-driven inflammatory disease
    • Nowak EC, Weaver CT, Turner H, et al.: IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med 2009;206: 1653-1660.
    • (2009) J Exp Med , vol.206 , pp. 1653-1660
    • Nowak, E.C.1    Weaver, C.T.2    Turner, H.3
  • 20
    • 37149016672 scopus 로고    scopus 로고
    • + regulatory T cells correlate with chronic hepatitis B infection
    • DOI 10.1111/j.1365-2567.2007.02691.x
    • Peng G, Li S, Wu W, Sun Z, Chen Y, and Chen Z: Circulating CD4 + CD25 + regulatory T cells correlate with chronic hepatitis B infection. Immunology 2008;123:57-65. (Pubitemid 350255997)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 57-65
    • Peng, G.1    Li, S.2    Wu, W.3    Sun, Z.4    Chen, Y.5    Chen, Z.6
  • 21
    • 35648968689 scopus 로고    scopus 로고
    • PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
    • DOI 10.1016/j.molimm.2007.07.038, PII S0161589007006736
    • Peng G, Li S, Wu W, Tan X, Chen Y, and Chen Z: PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol 2008;45:963-970. (Pubitemid 350019503)
    • (2008) Molecular Immunology , vol.45 , Issue.4 , pp. 963-970
    • Peng, G.1    Li, S.2    Wu, W.3    Tan, X.4    Chen, Y.5    Chen, Z.6
  • 22
    • 77958110459 scopus 로고    scopus 로고
    • Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections
    • Ribeiro RM, Germanidis G, Powers KA,. Pellegrin B, Nikolaidis P, Perelson AS, and Pawlotsky JM: Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections. J Infect Dis 2010;202:1309-1318.
    • (2010) J Infect Dis , vol.202 , pp. 1309-1318
    • Ribeiro, R.M.1    Germanidis, G.2    Powers, K.A.3    Pellegrin, B.4    Nikolaidis, P.5    Perelson, A.S.6    Pawlotsky, J.M.7
  • 23
    • 80052661223 scopus 로고    scopus 로고
    • Foxp3 expression in liver correlates with the degree but not the cause of inflammation
    • Speletas M, Argentou N, Germanidis G, et al.: Foxp3 expression in liver correlates with the degree but not the cause of inflammation. Mediators Inflamm 2011;827:565.
    • (2011) Mediators Inflamm , vol.827 , pp. 565
    • Speletas, M.1    Argentou, N.2    Germanidis, G.3
  • 25
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • DOI 10.1002/hep.20649
    • Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, and Janssen HL: Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005;41:771-778. (Pubitemid 40462939)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 771-778
    • Stoop, J.N.1    Van Der Molen, R.G.2    Baan, C.C.3    Van Der Laan, L.J.W.4    Kuipers, E.J.5    Kusters, J.G.6    Janssen, H.L.A.7
  • 26
    • 34047266620 scopus 로고    scopus 로고
    • Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B
    • DOI 10.1016/j.virol.2006.11.018, PII S0042682206008695
    • Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, and Janssen HL: Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B. Virology 2007;361:141-148. (Pubitemid 46551232)
    • (2007) Virology , vol.361 , Issue.1 , pp. 141-148
    • Stoop, J.N.1    Van Der Molen, R.G.2    Kuipers, E.J.3    Kusters, J.G.4    Janssen, H.L.A.5
  • 27
    • 33845905754 scopus 로고    scopus 로고
    • IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
    • DOI 10.1093/intimm/dxl117
    • Temann UA, Laouar Y, Eynon EE, Homer R, and Flavell RA: IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol 2007;19:1-10. (Pubitemid 46017882)
    • (2007) International Immunology , vol.19 , Issue.1 , pp. 1-10
    • Temann, U.-A.1    Laouar, Y.2    Eynon, E.E.3    Homer, R.4    Flavell, R.A.5
  • 29
    • 78650664290 scopus 로고    scopus 로고
    • Control of hepatitis B in China: Prevention and treatment
    • Wang Y, and Jia J: Control of hepatitis B in China: prevention and treatment. Expert Rev Anti Infect Ther 2011;9: 21-25.
    • (2011) Expert Rev Anti Infect Ther , vol.9 , pp. 21-25
    • Wang, Y.1    Jia, J.2
  • 30
    • 70350688076 scopus 로고    scopus 로고
    • Intrahepatic PD-1/PD-L1 upregulation closely correlates with inflammation and virus replication in patients with chronic HBV infection
    • Xie Z, Chen Y, Zhao S, et al.: Intrahepatic PD-1/PD-L1 upregulation closely correlates with inflammation and virus replication in patients with chronic HBV infection. Immunol Invest 2009;38:624-638.
    • (2009) Immunol Invest , vol.38 , pp. 624-638
    • Xie, Z.1    Chen, Y.2    Zhao, S.3
  • 32
    • 33846600414 scopus 로고    scopus 로고
    • + regulatory T cells with chronic activity and viral clearance in patients with hepatitis B
    • DOI 10.1093/intimm/dxl130
    • Yang G, Liu A, Xie Q, Guo TB, Wan B, Zhou B, and Zhang JZ: Association of CD4 + CD25 + Foxp3 + regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol 2007;19:133-140. (Pubitemid 46179008)
    • (2007) International Immunology , vol.19 , Issue.2 , pp. 133-140
    • Yang, G.1    Liu, A.2    Xie, Q.3    Guo, T.B.4    Wan, B.5    Zhou, B.6    Zhang, J.Z.7
  • 33
    • 80052365815 scopus 로고    scopus 로고
    • Upregulation of circulating PDL1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma
    • Zeng Z, Shi F, Zhou L, et al.: Upregulation of circulating PDL1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. PLoS One 2011;6:e23621.
    • (2011) PLoS One , vol.6
    • Zeng, Z.1    Shi, F.2    Zhou, L.3
  • 34
    • 78249257780 scopus 로고    scopus 로고
    • Decreased ratio of Treg cells to Th17 cells correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment
    • Zhang JY, Song CH, Shi F, Zhang Z, Fu JL, and Wang FS: Decreased ratio of Treg cells to Th17 cells correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment. PLoS One 2011;5:e13869.
    • (2011) PLoS One , vol.5
    • Zhang, J.Y.1    Song, C.H.2    Shi, F.3    Zhang, Z.4    Fu, J.L.5    Wang, F.S.6
  • 35
    • 73949089928 scopus 로고    scopus 로고
    • Overexpression of tolllike receptor 2/4 on monocytes modulates the activities of CD4( + )CD25( + ) regulatory T cells in chronic hepatitis B virus infection
    • Zhang Y, Lian JQ, Huang CX, et al.: Overexpression of tolllike receptor 2/4 on monocytes modulates the activities of CD4( + )CD25( + ) regulatory T cells in chronic hepatitis B virus infection. Virology 2010;397:34-42.
    • (2010) Virology , vol.397 , pp. 34-42
    • Zhang, Y.1    Lian, J.Q.2    Huang, C.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.