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Volumn 12, Issue 4, 2008, Pages 1229-1237

A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats

Author keywords

Adrenal gland; Aldosterone; Cytoplasmatic renin; Renin angiotensin system; Transgenic rats

Indexed keywords

ALDOSTERONE; ELECTROLYTE; MESSENGER RNA; RENIN;

EID: 43449135371     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00132.x     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 21244485420 scopus 로고    scopus 로고
    • Aldosterone biosynthesis, regulation, and classical mechanism of action
    • Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005 10 : 7 13.
    • (2005) Heart Fail Rev. , vol.10 , pp. 7-13
    • Williams, G.H.1
  • 2
    • 33846362954 scopus 로고    scopus 로고
    • Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system
    • Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007 292 : C82 97.
    • (2007) Am J Physiol Cell Physiol. , vol.292
    • Mehta, P.K.1    Griendling, K.K.2
  • 3
    • 0034705472 scopus 로고    scopus 로고
    • Cytokine actions of angiotensin II
    • Sadoshima J. Cytokine actions of angiotensin II. Circ Res. 2000 86 : 1187 9.
    • (2000) Circ Res. , vol.86 , pp. 1187-9
    • Sadoshima, J.1
  • 4
    • 0034177057 scopus 로고    scopus 로고
    • Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
    • Aoki H, Richmond M, Izumo S, Sadoshima J. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J. 2000 347 Pt 1 : 275 84.
    • (2000) Biochem J. , vol.347 , Issue.1 , pp. 275-84
    • Aoki, H.1    Richmond, M.2    Izumo, S.3    Sadoshima, J.4
  • 5
    • 0036672123 scopus 로고    scopus 로고
    • The renin-angiotensin system in the brain: Possible therapeutic implications for AT(1)-receptor blockers
    • Culman J, Blume A, Gohlke P, Unger T. The renin-angiotensin system in the brain: possible therapeutic implications for AT(1)-receptor blockers. J Hum Hypertens. 2002 16 : S64 70.
    • (2002) J Hum Hypertens. , vol.16
    • Culman, J.1    Blume, A.2    Gohlke, P.3    Unger, T.4
  • 6
    • 0025005906 scopus 로고
    • Morphology, physiology and molecular biology of renin secretion
    • Hackenthal E, Paul M, Ganten D, Taugner R. Morphology, physiology and molecular biology of renin secretion. Physiol Rev. 1990 70 : 1067 116.
    • (1990) Physiol Rev. , vol.70 , pp. 1067-116
    • Hackenthal, E.1    Paul, M.2    Ganten, D.3    Taugner, R.4
  • 7
    • 0035074165 scopus 로고    scopus 로고
    • Tissue renin-angiotensin systems: New insights from experimental animal models in hypertension research
    • Bader M, Peters J, Baltatu O, Muller DN, Luft FC, Ganten D. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. J Mol Med. 2001 79 : 76 102.
    • (2001) J Mol Med. , vol.79 , pp. 76-102
    • Bader, M.1    Peters, J.2    Baltatu, O.3    Muller, D.N.4    Luft, F.C.5    Ganten, D.6
  • 8
    • 0344528550 scopus 로고    scopus 로고
    • An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria
    • Clausmeyer S, Stürzebecher R, Peters J. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Circ Res. 1999 84 : 337 44.
    • (1999) Circ Res. , vol.84 , pp. 337-44
    • Clausmeyer, S.1    Stürzebecher, R.2    Peters, J.3
  • 9
    • 0033524747 scopus 로고    scopus 로고
    • Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing
    • Lee-Kirsch MA, Gaudet F, Cardoso MC, Lindpaintner K. Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res. 1999 84 : 240 6.
    • (1999) Circ Res. , vol.84 , pp. 240-6
    • Lee-Kirsch, M.A.1    Gaudet, F.2    Cardoso, M.C.3    Lindpaintner, K.4
  • 10
    • 0034729573 scopus 로고    scopus 로고
    • Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation
    • Sinn PL, Sigmund CD. Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics. 2000 3 : 25 31.
    • (2000) Physiol Genomics. , vol.3 , pp. 25-31
    • Sinn, P.L.1    Sigmund, C.D.2
  • 11
    • 0034463532 scopus 로고    scopus 로고
    • Tissue-specific expression of a rat renin transcript lacking the coding sequence for the prefragment and its stimulation by myocardial infarction
    • Clausmeyer S, Reinecke A, Farrenkopf R, Unger T, Peters J. Tissue-specific expression of a rat renin transcript lacking the coding sequence for the prefragment and its stimulation by myocardial infarction. Endocrinology. 2000 141 : 2963 70.
    • (2000) Endocrinology. , vol.141 , pp. 2963-70
    • Clausmeyer, S.1    Reinecke, A.2    Farrenkopf, R.3    Unger, T.4    Peters, J.5
  • 12
    • 0028063704 scopus 로고
    • Processing and secretion in adrenal and retina of transgenic (mREN-2)27 rats
    • Rong P, Berka JL, Kelly DJ, Alcorn D, Skinner SL. processing and secretion in adrenal and retina of transgenic (mREN-2)27 rats. Kidney Int. 1994 46 : 1583 7.
    • (1994) Kidney Int. , vol.46 , pp. 1583-7
    • Rong, P.1    Berka, J.L.2    Kelly, D.J.3    Alcorn, D.4    Skinner, S.L.5
  • 15
    • 0032933644 scopus 로고    scopus 로고
    • Glowing podocytes in living mouse: Transgenic mouse carrying a podocyte-specific promoter
    • Imai E, Akagi Y, Isaka Y, Ikawa M, Takenaka M, Hori M, Okabe M. Glowing podocytes in living mouse: transgenic mouse carrying a podocyte-specific promoter. Exp Nephrol. 1999 7 : 63 6.
    • (1999) Exp Nephrol. , vol.7 , pp. 63-6
    • Imai, E.1    Akagi, Y.2    Isaka, Y.3    Ikawa, M.4    Takenaka, M.5    Hori, M.6    Okabe, M.7
  • 16
    • 8244238387 scopus 로고    scopus 로고
    • Transcriptional activation of a hybrid promoter composed of cytomegalovirus enhancer and beta-actin/beta-globin gene in glomerular epithelial cells in vivo
    • Akagi Y, Isaka Y, Akagi A, Ikawa M, Takenaka M, Moriyama T, Yamauchi A, Horio M, Ueda N, Okabe M, Imai E. Transcriptional activation of a hybrid promoter composed of cytomegalovirus enhancer and beta-actin/beta-globin gene in glomerular epithelial cells in vivo. Kidney Int. 1997 51 : 1265 9.
    • (1997) Kidney Int. , vol.51 , pp. 1265-9
    • Akagi, Y.1    Isaka, Y.2    Akagi, A.3    Ikawa, M.4    Takenaka, M.5    Moriyama, T.6    Yamauchi, A.7    Horio, M.8    Ueda, N.9    Okabe, M.10    Imai, E.11
  • 17
    • 23044465809 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of angiotensin II type 1 receptor in transgenic rats
    • Hoffmann S. Cardiac-specific overexpression of angiotensin II type 1 receptor in transgenic rats. Methods Mol Med. 2005 112 : 389 403.
    • (2005) Methods Mol Med. , vol.112 , pp. 389-403
    • Hoffmann, S.1
  • 18
    • 0027456959 scopus 로고
    • Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium
    • Peters J, Münter K, Bader M, Hackenthal E, Mullins JJ, Ganten D. Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium. J Clin Invest. 1993 91 : 742 7.
    • (1993) J Clin Invest. , vol.91 , pp. 742-7
    • Peters, J.1    Münter, K.2    Bader, M.3    Hackenthal, E.4    Mullins, J.J.5    Ganten, D.6
  • 19
    • 0027946612 scopus 로고
    • The renin-angiotensin system in the heart and vascular wall: New therapeutic aspects
    • Falkenhahn M, Gohlke P, Paul M, Stoll M, Unger T. The renin-angiotensin system in the heart and vascular wall: new therapeutic aspects. J Cardiovasc Pharmacol. 1994 24 Suppl 2 : S6 13.
    • (1994) J Cardiovasc Pharmacol. , vol.24 , Issue.2
    • Falkenhahn, M.1    Gohlke, P.2    Paul, M.3    Stoll, M.4    Unger, T.5
  • 22
    • 0021237016 scopus 로고
    • Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations
    • Doi Y, Atarashi K, Franco-Saenz R, Mulrow PJ. Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations. Hypertension. 1984 6 : I124 9.
    • (1984) Hypertension. , vol.6
    • Doi, Y.1    Atarashi, K.2    Franco-Saenz, R.3    Mulrow, P.J.4
  • 23
    • 0022342862 scopus 로고
    • A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production
    • Nakamaru M, Misono KS, Naruse M, Workman RJ, Inagami T. A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production. Endocrinology. 1985 117 : 1772 8.
    • (1985) Endocrinology. , vol.117 , pp. 1772-8
    • Nakamaru, M.1    Misono, K.S.2    Naruse, M.3    Workman, R.J.4    Inagami, T.5
  • 24
    • 0031750547 scopus 로고    scopus 로고
    • Renin-angiotensin system in the adrenal
    • Mulrow PJ. Renin-angiotensin system in the adrenal. Horm Metab Res. 1998 30 : 346 9.
    • (1998) Horm Metab Res. , vol.30 , pp. 346-9
    • Mulrow, P.J.1
  • 25
    • 0031749406 scopus 로고    scopus 로고
    • Adrenal renin expression and its role in ren-2 transgenic rats TGR(mREN2)27
    • Peters J, Ganten D. Adrenal renin expression and its role in ren-2 transgenic rats TGR(mREN2)27. Horm Metab Res. 1998 30 : 350 4.
    • (1998) Horm Metab Res. , vol.30 , pp. 350-4
    • Peters, J.1    Ganten, D.2
  • 26
    • 0024384384 scopus 로고
    • Production of renin, angiotensin II, and aldosterone by adrenal explant cultures: Response to potassium and converting enzyme inhibition
    • Shier DN, Kusano E, Stoner GD, Franco-Saenz R, Mulrow PJ. Production of renin, angiotensin II, and aldosterone by adrenal explant cultures: response to potassium and converting enzyme inhibition. Endocrinology. 1989 125 : 486 91.
    • (1989) Endocrinology. , vol.125 , pp. 486-91
    • Shier, D.N.1    Kusano, E.2    Stoner, G.D.3    Franco-Saenz, R.4    Mulrow, P.J.5
  • 27
    • 0026625036 scopus 로고
    • Effect of angiotensin II on renin production by rat adrenal glomerulosa cells in culture
    • Yamaguchi T, Franco-Saenz R, Mulrow PJ. Effect of angiotensin II on renin production by rat adrenal glomerulosa cells in culture. Hypertension. 1992 19 : 263 9.
    • (1992) Hypertension. , vol.19 , pp. 263-9
    • Yamaguchi, T.1    Franco-Saenz, R.2    Mulrow, P.J.3
  • 28
    • 0025070125 scopus 로고
    • Exogenous and locally synthesized angiotensin II and glomerulosa cell functions
    • Horiba N, Nomura K, Shizume K. Exogenous and locally synthesized angiotensin II and glomerulosa cell functions. Hypertension. 1990 15 : 190 7.
    • (1990) Hypertension. , vol.15 , pp. 190-7
    • Horiba, N.1    Nomura, K.2    Shizume, K.3
  • 29
    • 0028963568 scopus 로고
    • Locally generated angiotensin II in the adrenal gland regulates basal, corticotropin-, and potassium-stimulated aldosterone secretion
    • Gupta P, Franco-Saenz R, Mulrow PJ. Locally generated angiotensin II in the adrenal gland regulates basal, corticotropin-, and potassium-stimulated aldosterone secretion. Hypertension. 1995 25 : 443 8.
    • (1995) Hypertension. , vol.25 , pp. 443-8
    • Gupta, P.1    Franco-Saenz, R.2    Mulrow, P.J.3
  • 30
    • 0032934775 scopus 로고    scopus 로고
    • Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system
    • Peters J, Obermuller N, Woyth A, Peters B, Maser-Gluth C, Kranzlin B, Gretz N. Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system. Endocrinology. 1999 140 : 675 82.
    • (1999) Endocrinology. , vol.140 , pp. 675-82
    • Peters, J.1    Obermuller, N.2    Woyth, A.3    Peters, B.4    Maser-Gluth, C.5    Kranzlin, B.6    Gretz, N.7
  • 31
    • 0036901544 scopus 로고    scopus 로고
    • Intracellular sorting of renin: Cell type specific differences and their consequences
    • Peters J, Clausmeyer S. Intracellular sorting of renin: cell type specific differences and their consequences. J Mol Cell Cardiol. 2002 34 : 1561 8.
    • (2002) J Mol Cell Cardiol. , vol.34 , pp. 1561-8
    • Peters, J.1    Clausmeyer, S.2
  • 33
    • 0015219676 scopus 로고
    • Angiotensin II : rrrrrapid localization in nuclei of smooth and cardiac muscle
    • Robertson AL Jr., Khairallah PA. Angiotensin II : rapid localization in nuclei of smooth and cardiac muscle. Science. 1971 172 : 1138 9.
    • (1971) Science. , vol.172 , pp. 1138-9
    • Robertson Jr., A.L.1    Khairallah, P.A.2
  • 34
    • 0041765635 scopus 로고    scopus 로고
    • Intracellular renin and the nature of intracrine enzymes
    • Re RN. Intracellular renin and the nature of intracrine enzymes. Hypertension. 2003 42 : 117 22.
    • (2003) Hypertension. , vol.42 , pp. 117-22
    • Re, R.N.1
  • 35
    • 0343627693 scopus 로고    scopus 로고
    • Angiotensin II and the heart : ooooon the intracrine renin-angiotensin system
    • De Mello WC, Danser AH. Angiotensin II and the heart : on the intracrine renin-angiotensin system. Hypertension. 2000 35 : 1183 8.
    • (2000) Hypertension. , vol.35 , pp. 1183-8
    • De Mello, W.C.1    Danser, A.H.2
  • 36
    • 0037784035 scopus 로고    scopus 로고
    • Effect of extracellular and intracellular angiotensins on heart cell function; On the cardiac renin-angiotensin system
    • De Mello W. Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system. Regul Pept. 2003 114 : 87 90.
    • (2003) Regul Pept. , vol.114 , pp. 87-90
    • De Mello, W.1
  • 37
    • 0032906089 scopus 로고    scopus 로고
    • Intracellular actions of angiotensin II in vascular smooth muscle cells
    • Haller H, Lindschau C, Quass P, Luft FC. Intracellular actions of angiotensin II in vascular smooth muscle cells. J Am Soc Nephrol. 1999 10 Suppl 11 : S75 83.
    • (1999) J Am Soc Nephrol. , vol.10 , Issue.11
    • Haller, H.1    Lindschau, C.2    Quass, P.3    Luft, F.C.4
  • 38
    • 0036179707 scopus 로고    scopus 로고
    • Intracellular angiotensin II stimulates voltage-operated Ca(2+) channels in arterial myocytes
    • Eto K, Ohya Y, Nakamura Y, Abe I, Iida M. Intracellular angiotensin II stimulates voltage-operated Ca(2+) channels in arterial myocytes. Hypertension. 2002 39 : 474 8.
    • (2002) Hypertension. , vol.39 , pp. 474-8
    • Eto, K.1    Ohya, Y.2    Nakamura, Y.3    Abe, I.4    Iida, M.5
  • 39
    • 0035824901 scopus 로고    scopus 로고
    • In vitro evidence for an intracellular site of angiotensin action
    • Cook JL, Zhang Z, Re RN. In vitro evidence for an intracellular site of angiotensin action. Circ Res. 2001 89 : 1138 46.
    • (2001) Circ Res. , vol.89 , pp. 1138-46
    • Cook, J.L.1    Zhang, Z.2    Re, R.N.3
  • 40
    • 0025231297 scopus 로고
    • Molecular cloning and sequence analysis of a cDNA encoding a porcine kidney renin-binding protein
    • Inoue H, Fukui K, Takahashi S, Miyake Y. Molecular cloning and sequence analysis of a cDNA encoding a porcine kidney renin-binding protein. J Biol Chem. 1990 265 : 6556 61.
    • (1990) J Biol Chem. , vol.265 , pp. 6556-61
    • Inoue, H.1    Fukui, K.2    Takahashi, S.3    Miyake, Y.4
  • 43
    • 0034532904 scopus 로고    scopus 로고
    • Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)
    • Takahashi S, Kumagai M, Shindo S, Saito K, Kawamura Y. Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein). J Biochem. 2000 128 : 951 6.
    • (2000) J Biochem. , vol.128 , pp. 951-6
    • Takahashi, S.1    Kumagai, M.2    Shindo, S.3    Saito, K.4    Kawamura, Y.5
  • 44
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002 109 : 1417 27.
    • (2002) J Clin Invest. , vol.109 , pp. 1417-27
    • Nguyen, G.1    Delarue, F.2    Burckle, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.D.6
  • 45
    • 33845608395 scopus 로고    scopus 로고
    • A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
    • Schefe JH, Menk M, Reinemund J, Effertz K, Hobbs RM, Pandolfi PP, Ruiz P, Unger T, Funke-Kaiser H. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006 99 : 1355 66.
    • (2006) Circ Res. , vol.99 , pp. 1355-66
    • Schefe, J.H.1    Menk, M.2    Reinemund, J.3    Effertz, K.4    Hobbs, R.M.5    Pandolfi, P.P.6    Ruiz, P.7    Unger, T.8    Funke-Kaiser, H.9


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