Peptides identified in soybean protein increase plasma cholesterol in mice on hypercholesterolemic diets

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 35, 2013, Pages 8389-8395

  Zhang, Huijuan ^a   Bartley, Glenn E ^b   Zhang, Hui ^c   Jing, Wang ^a   Fagerquist, Clifton K ^b   Zhong, Fang ^c   Yokoyama, Wallace ^b  

^a BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^b WESTERN REGIONAL RESEARCH CENTER   (United States)

^c JIANGNAN UNIVERSITY   (China)

Author keywords

bile acid; cholesterol; mice; micellar solution; peptides; soybean protein

Indexed keywords

BILE ACID; FECAL BILE ACID EXCRETION; LOW DENSITY LIPOPROTEINS; MICE; MICELLAR SOLUTION; NEGATIVE CORRELATION; PLASMA CHOLESTEROL; SOYBEAN PROTEINS;

BODY FLUIDS; CHOLESTEROL; GENE EXPRESSION; MAMMALS; NUTRITION; PHYSIOLOGY; PLASMAS;

PEPTIDES;

BILE ACID; CHOLESTEROL; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; PEPTIDE; SOYBEAN PROTEIN; STEROL 14ALPHA DEMETHYLASE;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; CHOLESTEROL INTAKE; DRUG EFFECT; FECES; GENETICS; HYPERCHOLESTEROLEMIA; MALE; MOUSE; UPREGULATION;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL, DIETARY; FECES; HYPERCHOLESTEROLEMIA; LIPOPROTEIN LIPASE; MALE; MICE; PEPTIDES; RECEPTORS, LDL; SOYBEAN PROTEINS; STEROL 14-DEMETHYLASE; UP-REGULATION;

EID: 84883694880     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4022288     Document Type: Article

References (36)

1. Sirtori, C. R.; Even, R.; Lovati, M. R. Soybean protein diet and plasma cholesterol: from therapy to molecular mechanisms Ann. N. Y. Acad. Sci. 1993, 676 (1) 188-201
2. Leveille, G. A.; Fisher, H. Plasma cholesterol in growing chicken as influenced by dietary protein and fat Proc. Soc. Exp. Biol. Med. 1958, 98 (3) 630-632
3. Cohn, J. S.; Kimpton, W. G.; Nestel, P. J. The effect of dietary casein and soy protein on cholesterol and very low density lipoprotein metabolism in the rat Atherosclerosis 1984, 52 (2) 219-231
4. Zhong, F.; Liu, J.; Ma, J.; Shoemaker, C. F. Preparation of hypocholesterol peptides from soy protein and their hypocholesterolemic effect in mice Food Res. Int. 2007, 40 (6) 661-667
5. Wright, S. M.; Salter, A. M. Effects of soy protein on plasma cholesterol and bile acid excretion in hamsters Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol. 1998, 119 (2) 247-254
6. Glicksman, C.; Pournaras, D. J.; Wright, M.; Roberts, R.; Mahon, D.; Welbourn, R.; Sherwood, R.; Alaghband-Zadeh, J.; le Roux, C. W. Postprandial plasma bile acid responses in normal weight and obese subjects Ann. Clin. Biochem. 2010, 47 (5) 482-484
7. Hamilton, R. M. G.; Carroll, K. K. Plasma cholesterol levels in rabbits fed low fat, low cholesterol diets effects of dietary proteins, carbohydrates and fibre from different sources Atherosclerosis 1976, 24 (1-2) 47-62
8. Yin, L.; Ma, H.; Ge, X.; Edwards, P. A.; Zhang, Y. Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis Arterioscler. Thromb. Vasc. Biol. 2011, 31 (2) 328-336
9. Zhong, F.; Zhang, X.; Ma, J.; Shoemaker, C. F. Fractionation and identification of a novel hypocholesterolemic peptide derived from soy protein Alcalase hydrolysates Food Res. Int. 2007, 40 (6) 756-762
10. Lovati, M. R.; Manzoni, C.; Gianazza, E.; Arnoldi, A.; Kurowska, E.; Carroll, K. K.; Sirtori, C. R. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells J. Nutr. 2000, 130 (10) 2543-2549
11. Cho, S. J.; Juillerat, M. A.; Lee, C. H. Identification of LDL-receptor transcription stimulating peptides from soybean hydrolysate in human hepatocytes J. Agric. Food Chem. 2008, 56 (12) 4372-4376
12. Nagaoka, S.; Nakamura, A.; Shibata, H.; Kanamaru, Y. Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats Biosci., Biotechnol., Biochem. 2010, 74 (8) 1738-1741
13. Yoshikawa, M.; Fujita, H.; Matoba, N.; Takenaka, Y.; Yamamoto, T.; Yamauchi, R.; Tsuruki, H.; Takahata, K. Bioactive peptides derived from food proteins preventing lifestyle-related diseases Biofactors 2000, 12 (1-4) 143-146
14. Smet, E. D.; Mensink, R. P.; Plat, J. Effects of plant sterols and stanols on intestinal cholesterol metabolism: suggested mechanisms from past to present Mol. Nutr. Food Res. 2012, 56 (7) 1058-1072
15. Ikeda, I.; Tanaka, K.; Sugano, M.; Vahouny, G. V.; Gallo, L. L. Discrimination between cholesterol and sitosterol for absorption in rats J. Lipid Res. 1988, 29 (12) 1583-1591
16. Van der Velde, A. E. Reverse cholesterol transport: from classical view to new insights World J. Gastroenterol. 2010, 16 (47) 5908-5915
17. Brufau, G.; Groen, A. K.; Kuipers, F. Reverse cholesterol transport revisited: Contribution of biliary versus intestinal cholesterol excretion Arterioscler. Thromb. Vasc. Biol. 2011, 31 (8) 1726-1733
18. Zaloga, G. P.; Siddiqui, R. A. Biologically active dietary peptides Mini. Rev. Med. Chem 2004, 4 (8) 815-821
19. German, J. B.; Xu, R.; Walzem, R.; Kinsella, J. E.; Knuckles, B.; Nakamura, M.; Yokoyama, W. H. Effect of dietary fats and barley fiber on total cholesterol and lipoprotein cholesterol distribution in plasma of hamsters Nutr. Res. (N. Y.) 1996, 16 (7) 1239-1249
20. Villanueva, M. J.; Yokoyama, W. H.; Hong, Y. J.; Barttley, G. E.; Rupérez, P. Effect of high-fat diets supplemented with okara soybean by-product on lipid profiles of plasma, liver and faeces in Syrian hamsters Food Chem. 2011, 124 (1) 72-79
21. Van Der Meer, R.; Vries, H. D.; Glatz, J. F. C. T-butanol extraction of feces: Rapid procedure for enzymic determination of fecal bile acids. In Cholesterol Metabolism in Health and Disease: Studies in the Netherlands; Beynen, A. C.; Geelen, M. J. H.; Katan, M. B.; Schouten, J. A., Eds.; Posen and Looijen: Wageningen, The Netherlands, 1985; pp 113-119.
22. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method Methods 2001, 25 (4) 402-408
23. Bartley, G. E.; Yokoyama, W.; Young, S. A.; Anderson, W. H. K.; Hung, S. C.; Albers, D. R.; Langhorst, M. L.; Kim, H. Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters J. Nutr. 2010, 140 (7) 1255-1260
24. Howard, A.; Udenigwe, C. C. Mechanisms and prospects of food protein hydrolysates and peptide-induced hypolipidaemia Food Funct. 2013, 4 (1) 40-51
25. Roberts, P. R.; Burney, J. D.; Black, K. W.; Zaloga, G. P. Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract Digestion 1999, 60 (4) 332-337
26. Hayashi, S.; Miyazaki, Y.; Yamashita, J.; Nakagawa, M.; Takizawa, H. Soy protein has no hypocholesterolemic action in mice because it does not stimulate fecal steroid excretion in that species Cell. Mol. Biol. (Noisy-Le-Grand) 1994, 40 (7) 1021-1028
27. Tovar, A. R.; Murguía, F.; Cruz, C.; Hernández-Pando, R.; Aguilar-Salinas, C. A.; Pedraza-Chaverri, J.; Correa-Rotter, R.; Torres, N. A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome J. Nutr. 2002, 132 (9) 2562-2569
28. Ascencio, C.; Torres, N.; Isoard-Acosta, F.; Gómez-Pérez, F. J.; Hernández-Pando, R.; Tovar, A. R. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats J. Nutr. 2004, 134 (3) 522-529
29. Nass, N.; Schoeps, R.; Ulbrich-Hofmann, R.; Simm, A.; Hohndorf, L.; Schmelzer, C.; Raith, K.; Neubert, R. H. H.; Eder, K. Screening for nutritive peptides that modify cholesterol 7α-hydroxylase expression J. Agric. Food Chem. 2008, 56 (13) 4987-4994
30. Kita, T.; Brown, M. S.; Bilheimer, D. W.; Goldstein, J. L. Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits Proc. Natl. Acad. Sci. U.S.A. 1982, 79 (18) 5693-5697
31. Lagor, W. R.; Millar, J. S. Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease J. Recept. Ligand Channel Res. 2010, 3 (1) 1-14
32. Jones, C.; Garuti, R.; Michaely, P.; Li, W. P.; Maeda, N.; Cohen, J. C.; Herz, J.; Hobbs, H. H. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia J. Clin. Invest. 2007, 117 (1) 165-174
33. Sirvent, A.; Verhoeven, A. J. M.; Jansen, H.; Kosykh, V.; Darteil, R. J.; Hum, D. W.; Fruchart, J. C.; Staels, B. Farnesoid X receptor represses hepatic lipase gene expression J. Lipid Res. 2004, 45 (11) 2110-2115
34. Calkin, A. C.; Tontonoz, P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat. Rev. Mol. Cell Biol. 2012, 13 (4) 213-224
35. Perret, B.; Mabile, L.; Martinez, L.; Tercé, F.; Barbaras, R.; Collet, X. Hepatic lipase: structure/function relationship, synthesis, and regulation J. Lipid Res. 2002, 43 (8) 1163-1169
36. Horton, J. D.; Goldstein, J. L.; Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 2002, 109 (9) 1125-1131