Modulation of T lymphocyte calcium influx patterns via the inhibition of Kv1.3 and IKCa1 potassium channels in autoimmune disorders

Frontiers in Immunology

Volumn 4, Issue AUG, 2013, Pages

  Orbán, Csaba ^a   Biró, Enikõ ^a   Grozdics, Enikõ ^a   Bajnok, Anna ^a   Toldi, Gergely ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; IKCA1 POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.3; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CALCIUM TRANSPORT; CELL ACTIVATION; CELL PROLIFERATION; CELLULAR IMMUNITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION;

EID: 84883665043     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00234     Document Type: Article

References (12)

1. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, et al. The voltage-gated Kv1.3 K (+) channel in effector memory T cells as new target for MS. J Clin Invest (2003) 111:1703-13. doi:10.1172/JCI16921
2. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci (2004) 25:280-9. doi:10.1016/j.tips.2004.03.010
3. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, et al. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A (2005) 102:11094-9. doi:10.1073/pnas.0501770102
4. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A (2006) 103:17414-9. doi:10.1073/pnas.0605136103
5. Rangaraju S, Chi V, Pennington MW, Chandy KG. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets (2009) 13:909-24. doi:10.1517/14728220903018957
6. Varga Z, Csepany T, Papp F, Fabian A, Gogolak P, Toth A, et al. Potassium channel expression in human CD4+ regulatory and naive T cells from healthy subjects and multiple sclerosis patients. Immunol Lett (2009) 124:95-101. doi:10.1016/j.imlet.2009.04.008
7. Kaposi AS, Veress G, Vasarhelyi B, Macardle P, Bailey S, Tulassay T, et al. Cytometry-acquired calcium-flux data analysis in activated lymphocytes. Cytometry A (2008) 73:246-53. doi:10.1002/cyto.a.20518
8. Toldi G, Vasarhelyi B, Kaposi A, Meszaros G, Panczel P, Hosszufalusi N, et al. Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels. Immunol Lett (2010) 133:35-41. doi:10.1016/j.imlet.2010.06.009
9. Toldi G, Folyovich A, Simon Z, Zsiga K, Kaposi A, Meszaros G, et al. Lymphocyte calcium influx kinetics in multiple sclerosis treated without or with interferon beta. J Neuroimmunol (2011) 237:80-6. doi:10.1016/j.jneuroim.2011.06.008
10. Toldi G, Bajnok A, Dobi D, Kaposi A, Kovacs L, Vasarhelyi B, et al. The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis. Immunobiology (2013) 218:311-6. doi:10.1016/j.imbio.2012.05.013
11. Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, et al. Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol (2000) 109:3-9. doi:10.1016/S0165-5728(00)00295-2
12. Yoon JW, Jun HS. Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus. Ann N Y Acad Sci (2001) 928:200-11. doi:10.1111/j.1749-6632.2001.tb05650.x