Lymphocyte activation in type 1 diabetes mellitus: The increased significance of Kv1.3 potassium channels

Immunology Letters

Volumn 133, Issue 1, 2010, Pages 35-41

  Toldi, Gergely ^a,b   Vásárhelyi, Barna ^b   Kaposi, Ambrus ^a,b   Mészáros, Gergo ^a,b   Pánczél, Pál ^a   Hosszufalusi, Nóra ^a   Tulassay, Tivadar ^a,b   Treszl, András ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Calcium influx; Kv1.3 potassium channel; Lymphocyte activation; Type 1 diabetes mellitus

Indexed keywords

CALCIUM; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3;

ADULT; ARTICLE; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CHANNEL GATING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADULT; ANTIGENS, CD4; ANTIGENS, CD8; CALCIUM SIGNALING; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KV1.3 POTASSIUM CHANNEL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PYRAZOLES; SCORPION VENOMS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 77955851454     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.06.009     Document Type: Article

References (17)

1. Crabtree G.R., Clipstone N.A. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 1994, 63:1045-1083.
2. + channels in T lymphocytes. Eur Biophys J 2005, 34:515-529.
3. Matteson D.R., Deutsch C. K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature 1984, 307:468-471.
4. Grissmer S., Nguyen A.N., Cahalan M.D. Calcium activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J Gen Physiol 1993, 102:601-630.
5. Cahalan M.D., Wulff H., Chandy K.G. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol 2001, 21:235-252.
6. Ghanshani S., Wulff H., Miller M.J., Rohm H., Neben A., Gutman G.A., et al. Upregulation of the IKCa1 potassium channel during T cell activation. Molecular mechanism and functional consequences. J Biol Chem 2000, 275:37137-37149.
7. + channel in effector memory T cells as new target for MS. J Clin Invest 2003, 111:1703-1713.
8. Beeton C., Wulff H., Standifer N.E., Azam P., Mullen K.M., Pennington M.W., et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci USA 2006, 103:17414-17419.
9. Garcia-Calvo M., Leonard R.J., Novick J., Stevens S.P., Schmalhofer W., Kaczorowski G.J., et al. Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J Biol Chem 1993, 268:18866-18874.
10. Wulff H., Gutman G.A., Cahalan M.D., Chandy K.G. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel IKCa1. J Biol Chem 2001, 276:32040-32045.
11. Kaposi A.S., Veress G., Vásárhelyi B., Macardle P., Bailey S., Tulassay T., et al. Cytometry-acquired calcium-flux data analysis in activated lymphocytes. Cytometry A 2008, 73:246-253.
12. Toldi G, Treszl A, Pongor V, Gyarmati B, Tulassay T, Vasarhelyi B. T-lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in the neonate. Int Immunol, 2010, doi:10.1093/intimm/dxq063.
13. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl. 1):S5-S10.
14. + channels as targets for specific immunomodulation. Trends Pharmacol Sci 2004, 25:280-289.
15. 2+ clearance distinguish Th1 and Th2 lymphocytes. J Immunol 2000, 164:1153-1160.
16. Yoon J.W., Jun H.S. Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus. Ann NY Acad Sci 2001, 928:200-211.
17. Basso A.S., Cheroutre H., Mucida D. More stories on Th17 cells. Cell Res 2009, 19:399-411.