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Volumn 20, Issue 5, 2013, Pages 460-466

Combination L-T3 and L-T4 therapy for hypothyroidism

Author keywords

combination T3 T4 therapy; hypothyroidism; thyroxine; triiodothyronine

Indexed keywords

DEIODINASE TYPE 1; DEIODINASE TYPE 2; DEIODINASE TYPE 3; IODIDE PEROXIDASE; LEVOTHYROXINE; LIOTHYRONINE; THYROTROPIN; UNCLASSIFIED DRUG;

EID: 84883654452     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/01.med.0000432611.03732.49     Document Type: Review
Times cited : (35)

References (62)
  • 1
    • 0345600946 scopus 로고    scopus 로고
    • 3 Therapy - Back to the Drawing Board
    • DOI 10.1001/jama.290.22.3002
    • Cooper DS. Combined T4 and T3 therapy: back to the drawing board. JAMA 2003; 290:3002-3004. (Pubitemid 37505535)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.22 , pp. 3002-3004
    • Cooper, D.S.1
  • 2
    • 0242288751 scopus 로고    scopus 로고
    • Editorial: In search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients
    • DOI 10.1210/jc.2003-031436
    • Kaplan MM, Sarne DH, Schneider AB. Editorial: in search of the impossible dream? Thyroid hormone replacement therapy that treats all symptoms in all hypothyroid patients. J Clin Endocrinol Metab 2003; 88:4540-4542. (Pubitemid 37357489)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.10 , pp. 4540-4542
    • Kaplan, M.M.1    Sarne, D.H.2    Schneider, A.B.3
  • 3
    • 0023867084 scopus 로고
    • Fine adjustment of thyroxine replacement dosage: Comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment
    • Carr D, McLeod DT, Parry G, et al. Fine adjustment of thyroxine replacement dosage: comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment. Clin Endocrinol 1988; 28:325-333. (Pubitemid 18079402)
    • (1988) Clinical Endocrinology , vol.28 , Issue.3 , pp. 325-333
    • Carr, D.1    McLeod, D.T.2    Parry, G.3    Thornes, H.M.4
  • 4
    • 18744419707 scopus 로고    scopus 로고
    • Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism
    • DOI 10.1056/NEJM199902113400603
    • Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ Jr. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999; 340:424-429. (Pubitemid 29084773)
    • (1999) New England Journal of Medicine , vol.340 , Issue.6 , pp. 424-429
    • Bunevicius, R.1    Kazanavicius, G.2    Zalinkevicius, R.3    Prange Jr., A.J.4
  • 6
    • 0025041194 scopus 로고
    • The use and limitations of chemiluminescent thyrotropin assay as a single thyroid function test in an out-patient endocrine clinic
    • Ross DS, Daniels GH, Gouveia D. The use and limitations of a chemiluminescent thyrotropin assay as a single thyroid function test in an outpatient endocrine clinic. J Clin Endocrinol Metab 1990; 71:764-769. (Pubitemid 20286081)
    • (1990) Journal of Clinical Endocrinology and Metabolism , vol.71 , Issue.3 , pp. 764-769
    • Ross, D.S.1    Danielg, G.H.2    Gouveia, D.3
  • 7
    • 0027481211 scopus 로고
    • Thyroxine prescription in the community: Serum thyroid stimulating hormone level assays as an indicator of undertreatment of overtreatment
    • Parle JV, Franklyn JA, Cross KW, et al. Thyroxine prescription in the community: serum thyroid stimulating hormone level assays as an indicator of undertreatment or overtreatment. Br J Gen Pract 1993; 43:107-109. (Pubitemid 23121696)
    • (1993) British Journal of General Practice , vol.43 , Issue.368 , pp. 107-109
    • Parle, J.V.1    Franklyn, J.A.2    Cross, K.W.3    Jones, S.R.4    Sheppard, M.C.5
  • 9
    • 0036426814 scopus 로고    scopus 로고
    • Psychological well-being in patients on 'adequate' doses of L-thyroxine: Results of a large, controlled community-based questionnaire study
    • DOI 10.1046/j.1365-2265.2002.01654.x
    • Saravanan P, Chau F, Roberts N, et al. Psychological well being in patients on 'adequate' doses of L-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf) 2002; 57: 577-585. (Pubitemid 35316973)
    • (2002) Clinical Endocrinology , vol.57 , Issue.5 , pp. 577-585
    • Saravanan, P.1    Chau, W.-F.2    Roberts, N.3    Vedhara, K.4    Greenwood, R.5    Dayan, C.M.6
  • 10
    • 2342456501 scopus 로고    scopus 로고
    • Combined Levotriiodothyronine and Levothyroxine Therapy for Hypothyroidism: Are We a Step Closer to the Magic Formula?
    • DOI 10.1089/105072504323030898
    • Wartofsky L. Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula? Thyroid 2004; 14:247-248. (Pubitemid 38569273)
    • (2004) Thyroid , vol.14 , Issue.4 , pp. 247-248
    • Wartofsky, L.1
  • 11
    • 0029938145 scopus 로고    scopus 로고
    • Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat
    • DOI 10.1210/en.137.6.2490
    • Escobar-Morreale HF, Escobar del Rey FE, Obregon MJ, Morreale de Escobar G. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology 1996; 137:2490-2502. (Pubitemid 26155786)
    • (1996) Endocrinology , vol.137 , Issue.6 , pp. 2490-2502
    • Escobar-Morreale, H.F.1    Del Rey, F.E.2    Obregon, M.J.3    De Escobar, G.M.4
  • 12
    • 0014953297 scopus 로고
    • Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism
    • Smith RN, Taylor SA, Massey JC. Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism. Br Med J 1970; 4:145-148.
    • (1970) Br Med J , vol.4 , pp. 145-148
    • Smith, R.N.1    Taylor, S.A.2    Massey, J.C.3
  • 14
    • 0033545344 scopus 로고    scopus 로고
    • Thyroid hormone replacement - One hormone or two?
    • Toft AD. Thyroid hormone replacement: one hormone or two? N Engl J Med 1999; 340:469-470. (Pubitemid 29084781)
    • (1999) New England Journal of Medicine , vol.340 , Issue.6 , pp. 469-470
    • Toft, A.D.1
  • 15
    • 0345060920 scopus 로고    scopus 로고
    • Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: A randomized controlled trial
    • DOI 10.1001/jama.290.22.2952
    • Clyde PW, Harari AE, Getka EJ, Shakir KMM. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism. JAMA 2003; 290:2952-2958. (Pubitemid 37505527)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.22 , pp. 2952-2958
    • Clyde, P.W.1    Harari, A.E.2    Getka, E.J.3    Shakir, K.M.M.4
  • 16
    • 0242288305 scopus 로고    scopus 로고
    • T4 plus T3 treatment for hypothyroidism: A double-blind comparison with usual T4
    • Los Angeles, CA
    • Levitt A, Silverberg J. T4 plus T3 treatment for hypothyroidism: a double-blind comparison with usual T4. Program 74th Annual Meeting, American Thyroid Association, Los Angeles, CA, 2002. Vol. 4 p. 112.
    • (2002) Program 74th Annual Meeting, American Thyroid Association , vol.4 , pp. 112
    • Levitt, A.1    Silverberg, J.2
  • 17
    • 0242288746 scopus 로고    scopus 로고
    • 4 Alone in Patients with Hypothyroidism? Results of a Double-Blind, Randomized, Controlled Trial
    • DOI 10.1210/jc.2003-030139
    • Sawka AM, Gerstein HC, Marriott MJ, et al. Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a doubleblind, randomized, controlled trial. J Clin Endocrinol Metab 2003; 88:4551-4555. (Pubitemid 37357491)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.10 , pp. 4551-4555
    • Sawka, A.M.1    Gerstein, H.C.2    Marriott, M.J.3    MacQueen, G.M.4    Joffe, R.T.5
  • 20
  • 22
    • 14844339782 scopus 로고    scopus 로고
    • Thyroid hormone replacement therapy in primary hypothyroidism: A randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone
    • Escobar-Morreale HF, Botella-Carretero JI, Gómez-Bueno M, et al. Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med 2005; 142:412-424.
    • (2005) Ann Intern Med , vol.142 , pp. 412-424
    • Escobar-Morreale, H.F.1    Botella-Carretero, J.I.2    Gómez-Bueno, M.3
  • 23
    • 33646439016 scopus 로고    scopus 로고
    • TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with l-thyroxine alone or in combination with l-triiodothyronine
    • Fadeyev VV, Morgunova TB, Sytch JP, Melnichenko GA. TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with l-thyroxine alone or in combination with l-triiodothyronine. Hormones 2005; 4:101-107.
    • (2005) Hormones , vol.4 , pp. 101-107
    • Fadeyev, V.V.1    Morgunova, T.B.2    Sytch, J.P.3    Melnichenko, G.A.4
  • 25
    • 30444437570 scopus 로고    scopus 로고
    • Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: Effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone
    • Rodriguez T, Lavis VR, Meininger JC, et al. Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. Endocr Pract 2005; 11:223-233.
    • (2005) Endocr Pract , vol.11 , pp. 223-233
    • Rodriguez, T.1    Lavis, V.R.2    Meininger, J.C.3
  • 26
  • 27
    • 72849126078 scopus 로고    scopus 로고
    • Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study
    • Nygaard B, Jensen EW, Kvetny J, et al. Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. Eur J Endocrinol 2009; 161:895-902.
    • (2009) Eur J Endocrinol , vol.161 , pp. 895-902
    • Nygaard, B.1    Jensen, E.W.2    Kvetny, J.3
  • 28
    • 33745768179 scopus 로고    scopus 로고
    • Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: Meta-analysis of randomized controlled trials
    • DOI 10.1210/jc.2006-0448
    • Grozinsky-Glasberg S, Fraser A, Nahshoni E, et al. Thyroxine- triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 2006; 91:2592-2599. (Pubitemid 44024623)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2592-2599
    • Grozinsky-Glasberg, S.1    Fraser, A.2    Nahshoni, E.3    Weizman, A.4    Leibovici, L.5
  • 29
    • 68349113552 scopus 로고    scopus 로고
    • Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism
    • Ma C, Xie J, Huang X, et al. Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism. Nucl Med Commun 2009; 30:586-593.
    • (2009) Nucl Med Commun , vol.30 , pp. 586-593
    • Ma, C.1    Xie, J.2    Huang, X.3
  • 30
    • 34548291456 scopus 로고    scopus 로고
    • Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: A literature review and metaanalysis
    • DOI 10.1176/appi.psy.48.5.379
    • Joffe RT, Brimacombe M, Levitt AJ, Stagnaro-Green A. Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: a literature review and metaanalysis. Psychosomatics 2007; 48:379-384. (Pubitemid 47330290)
    • (2007) Psychosomatics , vol.48 , Issue.5 , pp. 379-384
    • Joffe, R.T.1    Brimacombe, M.2    Levitt, A.J.3    Stagnaro-Green, A.4
  • 31
    • 0033920253 scopus 로고    scopus 로고
    • Mental improvement after replacement therapy with thyroxine plus triiodothyronine: Relationship to cause of hypothyroidism
    • DOI 10.1017/S1461145700001826
    • Bunevicius R, Prange AJ Jr. Mental improvement after replacement therapy with thyroxine plus triiodothyronine: relationship to cause of hypothyroidism. Int J Neuropsychopharmacol 2000; 3:167-174. (Pubitemid 30429360)
    • (2000) International Journal of Neuropsychopharmacology , vol.3 , Issue.2 , pp. 167-174
    • Bunevicius, R.1    Prange Jr., A.J.2
  • 32
    • 0036658669 scopus 로고    scopus 로고
    • Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves' disease
    • Bunevicius R, Jakuboniern N, Jurkevicius R, et al. Thyroxine vs. thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves' disease. Endocr J 2002; 18:129-133.
    • (2002) Endocr J , vol.18 , pp. 129-133
    • Bunevicius, R.1    Jakuboniern, N.2    Jurkevicius, R.3
  • 33
    • 2342519483 scopus 로고    scopus 로고
    • Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: Proof of principle
    • DOI 10.1089/105072504323030924
    • Hennemann G, Docter R, Visser TJ, et al. Thyroxine plus low-dose, slowrelease triiodothyronine replacement in hypothyroidism: proof of principle. Thyroid 2004; 14:271-275. (Pubitemid 38569276)
    • (2004) Thyroid , vol.14 , Issue.4 , pp. 271-275
    • Hennemann, G.1    Docter, R.2    Visser, T.J.3    Postema, P.T.4    Krenning, E.P.5
  • 35
    • 0036191639 scopus 로고    scopus 로고
    • Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
    • DOI 10.1210/er.23.1.38
    • Bianco AC, Salvatore D, Gereben B, et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 2002; 23:38-89. (Pubitemid 34185306)
    • (2002) Endocrine Reviews , vol.23 , Issue.1 , pp. 38-89
    • Bianco, A.C.1    Salvatore, D.2    Gereben, B.3    Berry, M.J.4    Larsen, P.R.5
  • 36
    • 39149116328 scopus 로고    scopus 로고
    • The clinical significance of subclinical thyroid dysfunction
    • DOI 10.1210/er.2006-0043
    • Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008; 29:76-131. (Pubitemid 351252748)
    • (2008) Endocrine Reviews , vol.29 , Issue.1 , pp. 76-131
    • Biondi, B.1    Cooper, D.S.2
  • 37
    • 76149115219 scopus 로고    scopus 로고
    • Age- and race-based serum thyrotropin reference limits
    • Surks MI, Boucai L. Age- and race-based serum thyrotropin reference limits. J Clin Endocrinol Metab 2010; 95:496-502.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 496-502
    • Surks, M.I.1    Boucai, L.2
  • 38
    • 0023199973 scopus 로고
    • Free thyroxine, free triiodothyronine, and thyrotropin concentrations in hypothyroid and thyroid carcinoma patients receiving thyroxine therapy
    • Liewendahl K, Helenius T, Lamberg BA, et al. Free thyroxine, free triiodothyronine, and thyrotropin concentrations in hypothyroid and thyroid carcinoma patients receiving thyroxine therapy. Acta Endocrinol (Copenh) 1987; 116:418-424. (Pubitemid 17154210)
    • (1987) Acta Endocrinologica , vol.116 , Issue.3 , pp. 418-424
    • Liewendahl, K.1    Helenius, T.2    Lamberg, B.-A.3    Mahonen, H.4    Wagar, G.5
  • 39
    • 0036123394 scopus 로고    scopus 로고
    • Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations
    • Woeber KA. 2002 Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. J Endocrinol Invest 2002; 25:106-109. (Pubitemid 34232608)
    • (2002) Journal of Endocrinological Investigation , vol.25 , Issue.2 , pp. 106-109
    • Woeber, K.A.1
  • 41
    • 0023103073 scopus 로고
    • Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism: Role of triiodothyronine in pituitary feedback in humans
    • Fish LH, Schwartz HL, Cavanaugh J, et al. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans. N Engl J Med 1987; 316: 764-770. (Pubitemid 17046084)
    • (1987) New England Journal of Medicine , vol.316 , Issue.13 , pp. 764-770
    • Fish, L.H.1    Schwartz, H.L.2    Cavanaugh, J.3
  • 42
    • 77149121414 scopus 로고    scopus 로고
    • Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer
    • Biondi B, Cooper DS. Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer. Thyroid 2010; 20:135-146.
    • (2010) Thyroid , vol.20 , pp. 135-146
    • Biondi, B.1    Cooper, D.S.2
  • 43
    • 79960953366 scopus 로고    scopus 로고
    • Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients
    • Gullo D, Latina A, Frasca F, et al. Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. PLoS One 2011; 6: e22552.
    • (2011) PLoS One , vol.6
    • Gullo, D.1    Latina, A.2    Frasca, F.3
  • 45
    • 0036317754 scopus 로고    scopus 로고
    • Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: Evidence of interaction with the Trp64Arg variant of the β-3-adrenergic receptor
    • Mentuccia D, Proietti-Pannunzi L, Tanner K, et al. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Argvariant of the beta-3-adrenergic receptor. Diabetes 2002; 51:880-883. (Pubitemid 34760206)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 880-883
    • Mentuccia, D.1    Proietti-Pannunzi, L.2    Tanner, K.3    Bacci, V.4    Pollin, T.I.5    Poehlman, E.T.6    Shuldiner, A.R.7    Celi, F.S.8
  • 46
    • 33847082534 scopus 로고    scopus 로고
    • Ala92 type 2 deiodinase allele increases risk for the development of hypertension
    • Gumieniak O, Perlstein TS, Williams JS, et al. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension 2007; 49:461-466.
    • (2007) Hypertension , vol.49 , pp. 461-466
    • Gumieniak, O.1    Perlstein, T.S.2    Williams, J.S.3
  • 47
    • 78649690156 scopus 로고    scopus 로고
    • The Thr92Ala 5' type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: A pharmacogenomic study
    • Butler PW, Smith SM, Linderman JD, et al. The Thr92Ala 5' type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: a pharmacogenomic study. Thyroid 2010; 20:1407-1412.
    • (2010) Thyroid , vol.20 , pp. 1407-1412
    • Butler, P.W.1    Smith, S.M.2    Linderman, J.D.3
  • 48
    • 66149144319 scopus 로고    scopus 로고
    • Common variation in the DIO2 gene predicts baseline psychological well being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients
    • Panicker V, Saravanan P, Vaidya B, et al. Common variation in the DIO2 gene predicts baseline psychological well being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab 2009; 94:1623-1629.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1623-1629
    • Panicker, V.1    Saravanan, P.2    Vaidya, B.3
  • 50
    • 67650330260 scopus 로고    scopus 로고
    • Thr92Ala polymorphism in the type 2 deiodinase is not associated with T4 dose in athyroid patients or patients with Hashimoto thyroiditis
    • Heemstra KA, Hoftijzer HC, van der Deure WM, et al. Thr92Ala polymorphism in the type 2 deiodinase is not associated with T4 dose in athyroid patients or patients with Hashimoto thyroiditis. Clin Endocrinol (Oxf) 2009; 71:279-283.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 279-283
    • Heemstra, K.A.1    Hoftijzer, H.C.2    Van Der Deure, W.M.3
  • 52
    • 0033920253 scopus 로고    scopus 로고
    • Mental improvement after replacement therapy with thyroxine plus triiodothyronine: Relationship to cause of hypothyroidism
    • DOI 10.1017/S1461145700001826
    • Bunevicius R, Prange AJ. Mental improvement after replacement therapy with thyroxine plus triiodothyronine: relationship to cause of hypothyroidism. Int J Neuropsychopharmacol 2000; 3:167-174. (Pubitemid 30429360)
    • (2000) International Journal of Neuropsychopharmacology , vol.3 , Issue.2 , pp. 167-174
    • Bunevicius, R.1    Prange Jr., A.J.2
  • 53
    • 80052538824 scopus 로고    scopus 로고
    • The type 2 deiodinase ORFa-Gly3Asp polymorphism (rs12885300) influences the set point of the hypothalamus-pituitary-thyroid axis in patients treated for differentiated thyroid carcinoma
    • Hoftijzer HC, Heemstra KA, Visser TJ, et al. The type 2 deiodinase ORFa-Gly3Asp polymorphism (rs12885300) influences the set point of the hypothalamus-pituitary-thyroid axis in patients treated for differentiated thyroid carcinoma. J Clin Endocrinol Metab 2011; 96:E1527-E1533.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Hoftijzer, H.C.1    Heemstra, K.A.2    Visser, T.J.3
  • 54
    • 77950269479 scopus 로고    scopus 로고
    • The pharmacodynamic equivalence of levothyroxine and liothyronine: A randomized, double blind, cross-over study in thyroidectomized patients
    • Celi FS, Zemskova M, Linderman JD, et al. The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. Clin Endocrinol 2010; 72:709-715.
    • (2010) Clin Endocrinol , vol.72 , pp. 709-715
    • Celi, F.S.1    Zemskova, M.2    Linderman, J.D.3
  • 55
    • 80655145199 scopus 로고    scopus 로고
    • Metabolic effects of liothyronine therapy in hypothyroidism: A randomized, double-blind, crossover trial of liothyronine versus levothyroxine
    • Celi FS, Zemskova M, Linderman JD, et al. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab 2011; 96: 3466-3474.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3466-3474
    • Celi, F.S.1    Zemskova, M.2    Linderman, J.D.3
  • 56
    • 84877712177 scopus 로고    scopus 로고
    • Desiccated thyroid extract compared to levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study
    • Hoang TD, Olsen CH, Mai VQ, et al. Desiccated thyroid extract compared to levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab 2013; 98:1982-1990.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1982-1990
    • Hoang, T.D.1    Olsen, C.H.2    Mai, V.Q.3
  • 58
    • 84870784432 scopus 로고    scopus 로고
    • Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    • American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults.
    • Garber JR, Cobin RH, Gharib H, et al., American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 2012; 22:1200-1235.
    • (2012) Thyroid , vol.22 , pp. 1200-1235
    • Garber, J.R.1    Cobin, R.H.2    Gharib, H.3
  • 59
    • 84883656699 scopus 로고    scopus 로고
    • Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American association of clinical endocrinologists and the american thyroid association
    • American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults.18:988-1028; Erratum in: Endocr Pract. Jan-Feb;
    • Garber JR, Cobin RH, Gharib H, et al., American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract 2012; 18:988-1028; Erratum in: Endocr Pract. 2013 Jan-Feb;19:175.
    • (2013) Endocr Pract 2012 , vol.19 , pp. 175
    • Garber, J.R.1    Cobin, R.H.2    Gharib, H.3
  • 60
    • 84883655713 scopus 로고    scopus 로고
    • Steady state serum T3 concentrations for 48 h following the oral administration of a single dose of T3 sulfate [abstract]
    • Endocrine Society
    • Santini F, Giannetti M, Ricco I, et al. Steady state serum T3 concentrations for 48 h following the oral administration of a single dose of T3 sulfate [abstract]. Endocrine Society 2013 Annual Meeting.
    • (2013) Annual Meeting
    • Santini, F.1    Giannetti, M.2    Ricco, I.3
  • 61
    • 84871046753 scopus 로고    scopus 로고
    • Guidelines: The use of L-T4 + L-T3 in the treatment of hypothyroidism
    • An insightful editorial comment on the controversy
    • Wiersinga WM, Duntas L, Fadeyev V, et al.Guidelines: the use of L-T4 + L-T3 in the treatment of hypothyroidism. Eur Thyroid J 2012; 1:55-57. An insightful editorial comment on the controversy.
    • (2012) Eur Thyroid J , vol.1 , pp. 55-57
    • Wiersinga, W.M.1    Duntas, L.2    Fadeyev, V.3
  • 62
    • 84877291070 scopus 로고    scopus 로고
    • European thyroid association guidelines on L-T4 + L-T3 combination for hypothyroidism: A weary step in the right direction
    • Perros P. European Thyroid Association Guidelines on L-T4 + L-T3 combination for hypothyroidism: a weary step in the right direction. Eur Thyroid J 2012; 1:51-54.
    • (2012) Eur Thyroid J , vol.1 , pp. 51-54
    • Perros, P.1


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