Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells

Clinical and Experimental Immunology

Volumn 174, Issue 1, 2013, Pages 179-191

  Litjens, N H R ^a   de Wit, E A ^a   Baan, C C ^a   Betjes, M G H ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Alloreactivity; CD137; CD4+ T cells; CD8+ T cells; Multi parameter analysis

Indexed keywords

CD137 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ALLOIMMUNITY; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOASSAY; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ALLOREACTIVITY; CD137; CD4+ T CELLS; CD8+ T CELLS; MULTI-PARAMETER ANALYSIS;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD137; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE DEPLETION; SENSITIVITY AND SPECIFICITY; STEM CELLS; T-LYMPHOCYTE SUBSETS;

EID: 84883625802     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12152     Document Type: Article

References (40)

1. Reinsmoen NL. Cellular methods used to evaluate the immune response in transplantation. Tissue Antigens 2002; 59:241-250.
2. Orosz CG, Adams PW, Ferguson RM. Frequency of human alloantigen-reactive T lymphocytes. II. Method for limiting dilution analysis of alloantigen-reactive helper T cells in human peripheral blood. Transplantation 1987; 43:718-724.
3. Kaminski E, Hows J, Goldman J, Batchelor R. Optimising a limiting dilution culture system for quantitating frequencies of alloreactive cytotoxic T lymphocyte precursors. Cell Immunol 1991; 137:88-95.
4. Sharrock CE, Kaminski E, Man S. Limiting dilution analysis of human T cells: a useful clinical tool. Immunol Today 1990; 11:281-286.
5. Hernandez-Fuentes MP, Warrens AN, Lechler RI. Immunologic monitoring. Immunol Rev 2003; 196:247-264.
6. Volk HD, Kern F. Insights into the specificity and function of (allo)antigen-reactive T cells. Am J Transplant 2001; 1:109-114.
7. Nikolaeva N, Uss E, van Leeuwen EM, van Lier RA, ten Berge IJ. Differentiation of human alloreactive CD4+ and CD8+ T cells in vitro. Transplantation 2004; 78:815-824.
8. Tapirdamaz O, Mancham S, van der Laan LJ etal. Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay. PLoS ONE 2010; 5:e14452.
9. Nomura LE, Walker JM, Maecker HT. Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells. Cytometry 2000; 40:60-68.
10. Suni MA, Picker LJ, Maino VC. Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry. J Immunol Methods 1998; 212:89-98.
11. Matesic D, Lehmann PV, Heeger PS. High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice. Transplantation 1998; 65:906-914.
12. Heeger PS, Greenspan NS, Kuhlenschmidt S etal. Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 1999; 163:2267-2275.
13. Litjens NH, van de Wetering J, van Besouw NM, Betjes MG. The human alloreactive CD4+ T-cell repertoire is biased to a Th17 response and the frequency is inversely related to the number of HLA class II mismatches. Blood 2009; 114:3947-3955.
14. Rentenaar RJ, Vosters JL, van Diepen FN, Remmerswaal EB, van Lier RA, ten Berge IJ. Differentiation of human alloreactive CD8(+) T cells in vitro. Immunology 2002; 105:278-285.
15. Suchin EJ, Langmuir PB, Palmer E, Sayegh MH, Wells AD, Turka LA. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol 2001; 166:973-981.
16. Chattopadhyay PK, Yu J, Roederer M. A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 2005; 11:1113-1117.
17. Frentsch M, Arbach O, Kirchhoff D etal. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 2005; 11:1118-1124.
18. Wolfl M, Kuball J, Ho WY etal. Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. Blood 2007; 110:201-210.
19. Zandvliet ML, van Liempt E, Jedema I etal. Simultaneous isolation of CD8(+) and CD4(+) T cells specific for multiple viruses for broad antiviral immune reconstitution after allogeneic stem cell transplantation. J Immunother 2011; 34:307-319.
20. Wehler TC, Nonn M, Brandt B etal. Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines. Blood 2007; 109:365-373.
21. Wolfl M, Kuball J, Eyrich M, Schlegel PG, Greenberg PD. Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities. Cytometry A 2008; 73:1043-1049.
22. Wehler TC, Karg M, Distler E etal. Rapid identification and sorting of viable virus-reactive CD4(+) and CD8(+) T cells based on antigen-triggered CD137 expression. J Immunol Methods 2008; 339:23-37.
23. Litjens NH, Huisman M, van den Dorpel M, Betjes MG. Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients. J Am Soc Nephrol 2008; 19:1483-1490.
24. Litjens NH, Boer K, Betjes MG. Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cells. J Immunol 2012; 188:1083-1090.
25. Betjes MG, Langerak AW, van der Spek A, de Wit EA, Litjens NH. Premature aging of circulating T cells in patients with end-stage renal disease. Kidney Int 2011; 80:208-217.
26. Litjens NH, de Wit EA, Betjes MG. Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun Ageing 2011; 8:2.
27. Rosa SCD, Lu FX, Yu J etal. Vaccination in humans generates broad T cell cytokine responses. J Immunol 2004; 173:5372-5380.
28. Betjes MG, Meijers RW, de Wit EA, Weimar W, Litjens NH. Terminally differentiated CD8+ temra cells are associated with the risk for acute kidney allograft rejection. Transplantation 2012; 94:63-69.
29. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-712.
30. Melenhorst JJ, Scheinberg P, Williams A etal. Alloreactivity across HLA barriers is mediated by both naive and antigen-experienced T cells. Biol Blood Marrow Transplant 2011; 17:800-809.
31. van Besouw NM, Vaessen LM, Zuijderwijk JM etal. The frequency of interferon-γ-producing cells reflects alloreactivity against minor histocompatibility antigens. Transplantation 2003; 75:1400-1404.
32. Reinsmoen NL, Cornett KM, Kloehn R etal. Pretransplant donor-specific and non-specific immune parameters associated with early acute rejection. Transplantation 2008; 85:462-470.
33. Atkins RC, Ford WL. Early cellular events in a systemic graft-vs.-host reaction. I. The migration of responding and nonresponding donor lymphocytes. J Exp Med 1975; 141:664-680.
34. Ford WL, Atkins RC. The proportion of lymphocytes capable of recognizing strong transplantation antigens in vivo. Adv Exp Med Biol 1973; 29:255-262.
35. Matzinger P, Bevan MJ. Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol 1977; 29:1-5.
36. Sherman LA, Chattopadhyay S. The molecular basis of allorecognition. Annu Rev Immunol 1993; 11:385-402.
37. Broen K, van der Waart AB, Greupink-Draaisma A etal. Polymorphisms in CCR6 are associated with chronic graft-versus-host disease and invasive fungal disease in matched-related hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17:1443-1449.
38. Ratajczak P, Janin A, Peffault de Latour R etal. Th17/Treg ratio in human graft-versus-host disease. Blood 2010; 116:1165-1171.
39. Vokaer B, Van Rompaey N, Lemaitre PH etal. Critical role of regulatory T cells in Th17-mediated minor antigen-disparate rejection. J Immunol 2010; 185:3417-3425.
40. Gerrits JH, van de Wetering J, Postma S etal. Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches. Nephrol Dial Transplant 2007; 22:353-361.