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Volumn 6, Issue , 2013, Pages 25-37

Safety and efficacy of sitagliptin-metformin in fixed combination for the treatment of type 2 diabetes mellitus

Author keywords

DPP 4 inhibitors; Incretin based therapies; Metformin; Sitagliptin; Type 2 diabetes

Indexed keywords

CIMETIDINE; DIGOXIN; EXENDIN 4; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; METFORMIN PLUS SITAGLIPTIN; MORPHINE; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN;

EID: 84883624784     PISSN: 11795514     EISSN: 11795514     Source Type: Journal    
DOI: 10.4137/CMED.S7314     Document Type: Review
Times cited : (11)

References (69)
  • 1
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782-7.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 2
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published correction appears in Lancet. 1998;352(9139):1558]. Lancet. 1998;352(9131):837-853.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 3
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyper-glycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
    • Nathan DM, Holman RR, Buse JB, et al. Medical management of hyper-glycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy. Diabetes Care. 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Holman, R.R.2    Buse, J.B.3
  • 4
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Diabetes Care. 2012;35(6): 1364-1379.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131:281-303.
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • Defronzo, R.A.1
  • 6
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientifc review
    • Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: scientifc review. JAMA. 2002;287:360-372.
    • (2002) JAMA , vol.287 , pp. 360-372
    • Inzucchi, S.E.1
  • 7
    • 14744287394 scopus 로고    scopus 로고
    • Glycemic management of type 2 diabetes: An emerging strategy with oral agents, insulins, and combinations
    • Riddle MC. Glycemic management of type 2 diabetes: An emerging strategy with oral agents, insulins, and combinations. Endocrinol Metab Clin North Am. 2005;34:77-98.
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 77-98
    • Riddle, M.C.1
  • 8
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29(1): 46-52.
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 9
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab. 2002;87(3):1239-1246.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 11
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, pep-tide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, pep-tide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993;214(3):829-835.
    • (1993) Eur J Biochem , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 12
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36) amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L, Deacon CF, Orskov C, Hoist JJ. Glucagon-like peptide-1-(7-36) amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology. 1999;140:5356-5363.
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Hoist, J.J.4
  • 14
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specifc metabolism in the anesthetized pig
    • Deacon CF, Pridal L, Klarskov L, Olesen M, Hoist JJ. Glucagon-like peptide 1 undergoes differential tissue-specifc metabolism in the anesthetized pig. Am J Physiol. 1996;2713:E458-E464.
    • Am J Physiol , vol.1996
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3    Olesen, M.4    Hoist, J.J.5
  • 15
    • 43149126332 scopus 로고    scopus 로고
    • Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects
    • Dai H, Gustavson SM, Preston GM, Eskra JD, Calle R, Hirshberg B. Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects. Diabetes Obes Metab. 2008;10(6):1463-2326.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.6 , pp. 1463-2326
    • Dai, H.1    Gustavson, S.M.2    Preston, G.M.3    Eskra, J.D.4    Calle, R.5    Hirshberg, B.6
  • 16
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Hoist JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36(8):741-744.
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Hoist, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 17
    • 53749085064 scopus 로고    scopus 로고
    • Incretin-based therapies in type 2 diabetes mellitus
    • Chia CW, Egan JM. Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2008;93(10):3703-3716.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 3703-3716
    • Chia, C.W.1    Egan, J.M.2
  • 18
    • 0042671284 scopus 로고    scopus 로고
    • Decreased glucagon-like peptide 1 fasting levels in type 2 diabetes
    • Legakis IN, Tzioras C, Phenekos C. Decreased glucagon-like peptide 1 fasting levels in type 2 diabetes. Diabetes Care. 2003;26(1):252.
    • (2003) Diabetes Care , vol.26 , Issue.1 , pp. 252
    • Legakis, I.N.1    Tzioras, C.2    Phenekos, C.3
  • 19
    • 0034880691 scopus 로고    scopus 로고
    • Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes
    • Toft-Nielsen MB, Madsbad S, Holst JJ. Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes. J Clin Endocrinol Metab. 2001;86:3853-3860.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3853-3860
    • Toft-Nielsen, M.B.1    Madsbad, S.2    Holst, J.J.3
  • 20
    • 0036216683 scopus 로고    scopus 로고
    • Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes
    • Lugari R, Dei Cas A, Ugolotti D, et al. Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes. Horm Metab Res. 2001;34:150-154.
    • (2001) Horm Metab Res , vol.34 , pp. 150-154
    • Lugari, R.1    Dei Cas, A.2    Ugolotti, D.3
  • 21
    • 40949090627 scopus 로고    scopus 로고
    • Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    • Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes. 2008;57:678-687.
    • (2008) Diabetes , vol.57 , pp. 678-687
    • Vollmer, K.1    Holst, J.J.2    Baller, B.3
  • 22
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glu-cagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down?
    • Nauck MA, Vardarli CF, Deacon CF, Hoist JJ, Meier JJ. Secretion of glu-cagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia. 2011;54:10-18.
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.A.1    Vardarli, C.F.2    Deacon, C.F.3    Hoist, J.J.4    Meier, J.J.5
  • 23
    • 0034614420 scopus 로고    scopus 로고
    • Dimethyl biguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir MY, Nogueira V, Fontaine E, Avéret N, Rigoulet M, Leverve X. Dimethyl biguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 2000;275:223-228.
    • (2000) J Biol Chem , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Avéret, N.4    Rigoulet, M.5    Leverve, X.6
  • 24
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne X, Foretz M, Taleux N, et al. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia. 2011;54:3101-3110.
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3
  • 25
    • 0037341552 scopus 로고    scopus 로고
    • Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin receptor substrate-2
    • Gunton JE, Delhanty PJ, Takahashi S, Baxter RC. Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin receptor substrate-2. J Clin Endocrinol Metab. 2003;88:1323-1332.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1323-1332
    • Gunton, J.E.1    Delhanty, P.J.2    Takahashi, S.3    Baxter, R.C.4
  • 26
    • 0035097211 scopus 로고    scopus 로고
    • Effect of metformin on gluca-gon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
    • Mannucci E, Ognibene A, Cremasco F, et al. Effect of metformin on gluca-gon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects. Diabetes Care. 2001;24(3):489-494.
    • (2001) Diabetes Care , vol.24 , Issue.3 , pp. 489-494
    • Mannucci, E.1    Ognibene, A.2    Cremasco, F.3
  • 27
    • 0036435607 scopus 로고    scopus 로고
    • Enhanced secretion of glucagon-like peptide 1 by biguanide compounds
    • Yasuda N, Inoue T, Nagakura T, et al. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochem Biophys Res Commun. 2002;298(5):779-784.
    • (2002) Biochem Biophys Res Commun , vol.298 , Issue.5 , pp. 779-784
    • Yasuda, N.1    Inoue, T.2    Nagakura, T.3
  • 28
    • 34548820996 scopus 로고    scopus 로고
    • Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
    • Bergman A, Ebel D, Liu F, et al. Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers. Biopharm Drug Dispos. Sep 2007;28(6):315-322.
    • (2007) Biopharm Drug Dispos , vol.28 , Issue.6 , pp. 315-322
    • Bergman, A.1    Ebel, D.2    Liu, F.3
  • 29
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharma-codynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman GA, Stevens C, Van Dyck K, et al. Pharmacokinetics and pharma-codynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005;78:675-688.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    van Dyck, K.3
  • 30
    • 34247269160 scopus 로고    scopus 로고
    • Dipeptidyl pepti-dase-4 inhibitors for the treatment of type 2 diabetes: Focus on sitagliptin
    • Herman GA, Stein PP, Thornberry NA, Wagner JA. Dipeptidyl pepti-dase-4 inhibitors for the treatment of type 2 diabetes: Focus on sitagliptin. Clin Pharmacol Ther. 2007;81:761-767.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 761-767
    • Herman, G.A.1    Stein, P.P.2    Thornberry, N.A.3    Wagner, J.A.4
  • 31
    • 70349325850 scopus 로고    scopus 로고
    • Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specifc glycaemic improvement
    • Alba M, Sheng D, Guan Y, et al. Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specifc glycaemic improvement. Curr Med Res Opin. 2009;25(10):2507-2514.
    • (2009) Curr Med Res Opin , vol.25 , Issue.10 , pp. 2507-2514
    • Alba, M.1    Sheng, D.2    Guan, Y.3
  • 32
    • 34547863123 scopus 로고    scopus 로고
    • Sitagliptin Study 035 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K, Kipnes M, Luo E, et al. Sitagliptin Study 035 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9(5):733-745.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3
  • 34
    • 84902472447 scopus 로고    scopus 로고
    • US Food and Drug Administration, marketed as Januvia and Janumet, Published 2009. Accessed Jun 26
    • US Food and Drug Administration. Information for healthcare professionals: acute pancreatitis and sitagliptin (marketed as Januvia and Janumet). http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformation-forPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm183764. Published 2009. Accessed Jun 26, 2013.
    • (2013) Information For Healthcare Professionals: Acute Pancreatitis and Sitagliptin
  • 35
    • 84876063836 scopus 로고    scopus 로고
    • Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: A population-based matched case-control study
    • Singh S, Chang HY, Richards TM, Weiner JP, Clark JM, Segal JB. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med. 2013;173(7):534-539.
    • (2013) JAMA Intern Med , vol.173 , Issue.7 , pp. 534-539
    • Singh, S.1    Chang, H.Y.2    Richards, T.M.3    Weiner, J.P.4    Clark, J.M.5    Segal, J.B.6
  • 36
    • 84878185729 scopus 로고    scopus 로고
    • A Critical analysis of the clinical use of incretin-based therapies. Are the glp-1 therapies safe
    • Butler PC, Elashoff M, Elashoff R, Gale EA. A critical analysis of the clinical use of incretin-based therapies. Are the glp-1 therapies safe? Diabetes Care. 2013;36(7):2118-2125.
    • (2013) Diabetes Care , vol.36 , Issue.7 , pp. 2118-2125
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.4
  • 37
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: The benefts by far outweigh the potential risks
    • Nauck MA. A critical analysis of the clinical use of incretin-based therapies: The benefts by far outweigh the potential risks. Diabetes Care. 2013;36(7): 2126-2132.
    • (2013) Diabetes Care , vol.36 , Issue.7 , pp. 2126-2132
    • Nauck, M.A.1
  • 38
    • 84880091008 scopus 로고    scopus 로고
    • Incretin therapy and islet pathology: A time for caution
    • Kahn SE. Incretin therapy and islet pathology: a time for caution. Diabetes. 2013;62:2178-2180.
    • (2013) Diabetes , vol.62 , pp. 2178-2180
    • Kahn, S.E.1
  • 40
    • 0029933886 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of metformin
    • Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 1996;30:359-371.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 359-371
    • Scheen, A.J.1
  • 42
    • 84883613392 scopus 로고    scopus 로고
    • (sitagliptin/metformin HCl) Tablets [package insert]. Whitehouse Station, NJ, Inc
    • Janumet TM (sitagliptin/metformin HCl) Tablets [package insert]. Whitehouse Station, NJ: Merck Pharmaceuticals, Inc; 2012.
    • (2012) Merck Pharmaceuticals
    • Janumet, T.M.1
  • 43
    • 0023204364 scopus 로고
    • Reduction of met-formin renal tubular secretion by cimetidine in man
    • Somogyi A, Stockley C, Keal J, Rolan P, Bochner F. Reduction of met-formin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol. 1987;23(5):545-551.
    • (1987) Br J Clin Pharmacol , vol.23 , Issue.5 , pp. 545-551
    • Somogyi, A.1    Stockley, C.2    Keal, J.3    Rolan, P.4    Bochner, F.5
  • 44
    • 0030983676 scopus 로고    scopus 로고
    • Metformin hydrochloride: An antihyperglycaemic agent
    • Klepser TB, Kelly MW. Metformin hydrochloride: an antihyperglycaemic agent. Am J Health Syst Pharm. 1997;54(8):893-903.
    • (1997) Am J Health Syst Pharm , vol.54 , Issue.8 , pp. 893-903
    • Klepser, T.B.1    Kelly, M.W.2
  • 45
    • 77952932759 scopus 로고    scopus 로고
    • Princeton, NJ: Bristol-Myers Squibb, Accessed Dec 7, 2011
    • Glucophage (metformin) [package insert]. Princeton, NJ: Bristol-Myers Squibb; 2009. http://packageinserts.bms.com/pi/pi_glucophage.pdf. Accessed Dec 7, 2011.
    • (2009) Glucophage (metformin) [package Insert]
  • 46
    • 77957775197 scopus 로고    scopus 로고
    • Bioequivalence of sitagliptin/ metformin fxed-dose combination tablets and concomitant administration of sitagliptin and metformin in healthy adult subjects: A randomized, open-label, crossover study
    • Migoya EM, Miller JL, Gutierrez M, et al. Bioequivalence of sitagliptin/ metformin fxed-dose combination tablets and concomitant administration of sitagliptin and metformin in healthy adult subjects: a randomized, open-label, crossover study. Clin Drug Investig. 2010;30(12):855-866.
    • (2010) Clin Drug Investig , vol.30 , Issue.12 , pp. 855-866
    • Migoya, E.M.1    Miller, J.L.2    Gutierrez, M.3
  • 47
    • 33750517754 scopus 로고    scopus 로고
    • Sitagliptin Study 012 Group. Tolerability and pharmacokinetics of metformin and the dipeptidyl pepti-dase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
    • Herman GA, Bergman A, Yi B, Kipnes M; Sitagliptin Study 012 Group. Tolerability and pharmacokinetics of metformin and the dipeptidyl pepti-dase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes. Curr Med Res Opin. 2006;22(10):1939-1947.
    • (2006) Curr Med Res Opin , vol.22 , Issue.10 , pp. 1939-1947
    • Herman, G.A.1    Bergman, A.2    Yi, B.3    Kipnes, M.4
  • 48
    • 0036211463 scopus 로고    scopus 로고
    • Adherence to oral antidiabetic therapy in a managed care organization: A comparison of monotherapy, combination therapy, and fxed-dose combination therapy
    • Melikian C, White TJ, Vanderplas A, Dezil CM, Chang E. Adherence to oral antidiabetic therapy in a managed care organization: a comparison of monotherapy, combination therapy, and fxed-dose combination therapy. Clin Ther. 2002;24:460-467.
    • (2002) Clin Ther , vol.24 , pp. 460-467
    • Melikian, C.1    White, T.J.2    Vanderplas, A.3    Dezil, C.M.4    Chang, E.5
  • 49
    • 0344897714 scopus 로고    scopus 로고
    • 1c in type 2 diabetic patients new to therapy with glyburide/metformin tablets as compared to glyburide co-administered with metformin
    • Blonde L, Wogen J, Kreilick C, Seymour AA. Greater reductions in A1c in type 2 diabetic patients new to therapy with glyburide/metformin tablets as compared to glyburide co-administered with metformin. Diabetes Obes Metab. 2003;5:424-431.
    • (2003) Diabetes Obes Metab , vol.5 , pp. 424-431
    • Blonde, L.1    Wogen, J.2    Kreilick, C.3    Seymour, A.A.4
  • 50
    • 79956315355 scopus 로고    scopus 로고
    • The effect of initial therapy with fxed dose combination of sitagliptin and metformin compared with met-formin monotherapy in patients with type 2 diabetes mellitus
    • Reasner C, Olansky L, Seck TL, et al. The effect of initial therapy with fxed dose combination of sitagliptin and metformin compared with met-formin monotherapy in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2011;13:644-652.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 644-652
    • Reasner, C.1    Olansky, L.2    Seck, T.L.3
  • 51
    • 80051872773 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin and the fxed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naïve patients with type 2 diabetes
    • Pérez-Monteverde A, Seck T, Xu L, et al. Efficacy and safety of sitagliptin and the fxed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naïve patients with type 2 diabetes. Int J Clin Pract. 2011;65(9): 930-938.
    • (2011) Int J Clin Pract , vol.65 , Issue.9 , pp. 930-938
    • Pérez-Monteverde, A.1    Seck, T.2    Xu, L.3
  • 52
    • 84859444408 scopus 로고    scopus 로고
    • Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemia control compared with pioglitazone monotherapy in patients with type 2 diabetes
    • Wainstein J, Katz L, Engel SS, et al. Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemia control compared with pioglitazone monotherapy in patients with type 2 diabetes. Diabetes Obes Metab. 2012;14:409-418.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 409-418
    • Wainstein, J.1    Katz, L.2    Engel, S.S.3
  • 53
    • 34547660561 scopus 로고    scopus 로고
    • Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidylpeptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE; Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidylpeptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979-1987.
    • (2007) Diabetes Care , vol.30 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3    Johnson, J.4    Williams-Herman, D.E.5
  • 54
    • 65449135058 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: A 54-week study
    • Williams-Herman D, Johnson J, Teng R, et al. Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study. Curr Med Res Opin. 2009;25(3):569-583.
    • (2009) Curr Med Res Opin , vol.25 , Issue.3 , pp. 569-583
    • Williams-Herman, D.1    Johnson, J.2    Teng, R.3
  • 55
    • 77952083721 scopus 로고    scopus 로고
    • Efficacy and safety of sitaglip-tin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes
    • Williams-Herman D, Johnson J, Teng R, et al. Efficacy and safety of sitaglip-tin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12(5): 442-451.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.5 , pp. 442-451
    • Williams-Herman, D.1    Johnson, J.2    Teng, R.3
  • 56
    • 33845476757 scopus 로고    scopus 로고
    • Sitagliptin Study 020 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor sita-gliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor sita-gliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29(12): 2638-2643.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 57
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I, Chen Y, Wu M, et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin. 2008;24(2):537-550.
    • (2008) Curr Med Res Opin , vol.24 , Issue.2 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 59
    • 33846817233 scopus 로고    scopus 로고
    • Sitagliptin Study 024 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, noninferiority trial
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP; Sitagliptin Study 024 Group. Effcacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, noninferiority trial. Diabetes Obes Metab. 2007;9:194-205.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 60
    • 43449096512 scopus 로고    scopus 로고
    • Sitagliptin Study 801 Group. Effcacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Scott R, Loeys T, Davies MJ, Engel SS; Sitagliptin Study 801 Group. Effcacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008;10:959-969.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 61
    • 77958030736 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adults patients with type 2 diabetes mellitus
    • Scheen AJ, Charpentier G, Ostgren CJ, Hellqvist A, Gause-Nilsson I. Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adults patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2010;26:540-549.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 540-549
    • Scheen, A.J.1    Charpentier, G.2    Ostgren, C.J.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 62
    • 77955573674 scopus 로고    scopus 로고
    • DURATION-2 Study Group. Effcacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, Macconell L, et al. DURATION-2 Study Group. Effcacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial. Lancet. 2010;376:431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3
  • 63
    • 78651338445 scopus 로고    scopus 로고
    • Executive summary: Standards of medical care in diabetes-2011
    • American Diabetes Association
    • American Diabetes Association. Executive summary: standards of medical care in diabetes-2011. Diabetes Care. 2011;34(Suppl 1):S11-S61.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 64
    • 84865598594 scopus 로고    scopus 로고
    • International Diabetes Center treatment of type 2 diabetes glucose algorithm
    • Simonson GD, Cuddihy RM, Reader D, Bergenstal RM. International Diabetes Center treatment of type 2 diabetes glucose algorithm. Diabetes Manag. 2011;1:175-189.
    • (2011) Diabetes Manag , vol.1 , pp. 175-189
    • Simonson, G.D.1    Cuddihy, R.M.2    Reader, D.3    Bergenstal, R.M.4
  • 65
    • 33845405222 scopus 로고    scopus 로고
    • ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, et al. ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 66
    • 33845746899 scopus 로고    scopus 로고
    • Severe iatrogenic hypoglycemia in type 2 diabetes mellitus
    • Cryer PE. Severe iatrogenic hypoglycemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab. 2007;3:4-5.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 4-5
    • Cryer, P.E.1
  • 67
    • 24144480574 scopus 로고    scopus 로고
    • PRESERVE-beta: Two-year effcacy and safety of initial combination therapy with nat-eglinide or glyburide plus metformin
    • Gerich J, Raskin P, Jean-Louis L, Purkayastha D, Baron MA. PRESERVE-beta: two-year effcacy and safety of initial combination therapy with nat-eglinide or glyburide plus metformin. Diabetes Care. 2005;28:2093-2209.
    • (2005) Diabetes Care , vol.28 , pp. 2093-2209
    • Gerich, J.1    Raskin, P.2    Jean-Louis, L.3    Purkayastha, D.4    Baron, M.A.5
  • 68
    • 79953203593 scopus 로고    scopus 로고
    • Comparative cardiovascular effects of thiazo-lidinediones: Systematic review and meta-analysis of observational studies
    • Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazo-lidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309.
    • (2011) BMJ , vol.342
    • Loke, Y.K.1    Kwok, C.S.2    Singh, S.3
  • 69
    • 38849100174 scopus 로고    scopus 로고
    • Cancer incidence among patients treated with antidiabetic pharmacotherapy
    • Oliveria SA, Koro CE, Yood MU, Sowell M. Cancer incidence among patients treated with antidiabetic pharmacotherapy. Clin Res Rev. 2008;2:47-57.
    • (2008) Clin Res Rev , vol.2 , pp. 47-57
    • Oliveria, S.A.1    Koro, C.E.2    Yood, M.U.3    Sowell, M.4


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